Brown adipose tissue-a new role in humans?

Nature Reviews Endocrinology

Volumn 6, Issue 6, 2010, Pages 319-325

  Lidell, Martin E ^a   Enerbäck, Sven ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; FLUORODEOXYGLUCOSE F 18; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 1;

BODY MASS; BODY TEMPERATURE; BROWN ADIPOSE TISSUE; CALORIC INTAKE; COMPUTER ASSISTED TOMOGRAPHY; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; THERMOGENESIS; WEIGHT GAIN;

ADAPTATION, PHYSIOLOGICAL; ADIPOSE TISSUE; ADIPOSE TISSUE, BROWN; ADRENERGIC AGONISTS; ANIMALS; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; HUMANS; OBESITY; RECEPTORS, ADRENERGIC, BETA-2; THERMOGENESIS; THIAZOLIDINEDIONES; TISSUE ENGINEERING;

EID: 77952958684     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2010.64     Document Type: Review

References (78)

1. Hossain, P., Kawar, B. & El Nahas, M. Obesity and diabetes in the developing world-a growing challenge. N. Engl. J. Med. 356, 213-215 (2007).
2. Shulman, G. I. Cellular mechanisms of insulin resistance. J. Clin. Invest. 106, 171-176 (2000).
3. Qatanani, M. & Lazar, M. A. Mechanisms of obesity-associated insulin resistance: many choices on the menu. Genes Dev. 21, 1443-1455 (2007).
4. Fruhbeck, G., Becerril, S., Sainz, N., Garrastachu, P. & Garciavelloso, M. J. BAT: a new target for human obesity? Trends Pharmacol. Sci. 30, 387-396 (2009).
5. Gesta, S., Tseng, Y. H. & Kahn, C. R. Developmental origin of fat: tracking obesity to its source. Cell 131, 242-256 (2007).
6. Timmons, J. A. et al. Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc. Natl Acad. Sci. USA 104, 4401-4406 (2007).
7. Seale, P. et al. PrDM16 controls a brown fat/skeletal muscle switch. Nature 454, 961-967 (2008).
8. Atit, R. et al. Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. Dev. Biol. 296, 164-176 (2006).
9. Seale, P. et al. Transcriptional control of brown fat determination by PrDM16. Cell Metab. 6, 38-54 (2007).
10. Kajimura, S. et al. Regulation of the brown and white fat gene programs through a PrDM16/CtBP transcriptional complex. Genes Dev. 22, 1397-1409 (2008).
11. Kajimura, S. et al. Initiation of myoblast to brown fat switch by a PrDM16-C/EBP-beta transcriptional complex. Nature 460, 1154-1158 (2009).
12. Tseng, Y. H. et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454, 1000-1004 (2008).
13. Cousin, B. et al. Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J. Cell. Sci. 103, 931-942 (1992).
14. Guerra, C., Koza, R. A., Yamashita, H., Walsh, K. & Kozak, L. P. Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J. Clin. Invest. 102, 412-420 (1998).
15. Himms-Hagen, J. et al. Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes. Am. J. Physiol. Cell Physiol. 279, C670-C681 (2000).
16. Xue, B. et al. Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat. J. Lipid Res. 48, 41-51 (2007).
17. Tang, W. et al. White fat progenitor cells reside in the adipose vasculature. Science 322, 583-586 (2008).
18. Seale, P., Kajimura, S. & Spiegelman, B. M. Transcriptional control of brown adipocyte development and physiological function-of mice and men. Genes Dev. 23, 788-797 (2009).
19. vernochet, C., Peres, S. B. & Farmer, S. R. Mechanisms of obesity and related pathologies: transcriptional control of adipose tissue development. FEBS J. 276, 5729-5737 (2009).
20. Farmer, S. R. Molecular determinants of brown adipocyte formation and function. Genes Dev. 22, 1269-1275 (2008).
21. Smith, R. E. & Horwitz, B. A. Brown fat and thermogenesis. Physiol. Rev. 49, 330-425 (1969).
22. Lowell, B. B. & Spiegelman, B. M. Towards a molecular understanding of adaptive thermogenesis. Nature 404, 652-660 (2000).
23. Cannon, B. & Nedergaard, J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 84, 277-359 (2004).
24. Davis, T. R., Johnston, D. R., Bell, F. C. & Cremer, B. J. regulation of shivering and non? shivering heat production during acclimation of rats. Am. J. Physiol. 198, 471-475 (1960).
25. Davis, T. R. Chamber cold acclimatization in man. J. Appl. Physiol. 16, 1011-1015 (1961).
26. Golozoubova, v. et al. Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold. FASEB J. 15, 2048-2050 (2001).
27. Jacobsson, A., Stadler, U., Glotzer, M. A. & Kozak, L. P. Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mrNA expression. J. Biol. Chem. 260, 16250-16254 (1985).
28. Krauss, S., Zhang, C. Y. & Lowell, B. B. The mitochondrial uncoupling-protein homologs. Nat. Rev. Mol. Cell Biol. 6, 248-261 (2005).
29. Puigserver, P. et al. A cold-inducible co-activator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829-839 (1998).
30. Silva, J. E. & Larsen, P. R. Adrenergic activation of triiodothyronine production in brown adipose tissue. Nature 305, 712-713 (1983).
31. Puigserver, P. & Spiegelman, B. M. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha) : transcriptional co-activator and metabolic regulator. Endocr. Rev. 24, 78-90 (2003).
32. Bukowiecki, L., Collet, A. J., Follea, N., Guay, G. & Jahjah, L. Brown adipose tissue hyperplasia: a fundamental mechanism of adaptation to cold and hyperphagia. Am. J. Physiol. 242, E353-E359 (1982).
33. Lowell, B. B. et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366, 740-742 (1993).
34. Enerback, S. et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387, 90-94 (1997).
35. Thomas, S. A. & Palmiter, R. D. Thermoregulatory and metabolic phenotypes of mice lacking norepinephrine and epinephrine. Nature 387, 94-97 (1997).
36. Bachman, E. S. et al. BetaAr signaling required for diet-induced thermogenesis and obesity resistance. Science 297, 843-845 (2002).
37. Lowell, B. B. & Bachman, E. S. Beta-adrenergic receptors, diet-induced thermogenesis, and obesity. J. Biol. Chem. 278, 29385-29388 (2003).
38. rothwell, N. J. & Stock, M. J. A role for brown adipose tissue in diet-induced thermogenesis. Nature 281, 31-35 (1979).
39. Hamann, A., Flier, J. S. & Lowell, B. B. Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology 137, 21-29 (1996).
40. Cederberg, A. et al. FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 106, 563-573 (2001).
41. Kim, J. K. et al. Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance. Diabetes 54, 1657-1663 (2005).
42. Zhou, Z. et al. Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat. Genet. 35, 49-56 (2003).
43. Strosberg, A. D. & Pietrirouxel, F. Function and regulation of the beta 3-adrenoceptor. Trends Pharmacol. Sci. 17, 373-381 (1996).
44. Ursino, M. G., vasina, V., Raschi, E., Crema, F. & De Ponti, F. The beta3-adrenoceptor as a therapeutic target: current perspectives. Pharmacol. Res. 59, 221-234 (2009).
45. Friedman, J. M. & Halaas, J. L. Leptin and the regulation of body weight in mammals. Nature 395, 763-770 (1998).
46. Knehans, A. W. & Romsos, D. R. Reduced norepinephrine turnover in brown adipose tissue of ob/ob mice. Am. J. Physiol. 242, E253-E261 (1982).
47. Collins, S. et al. Role of leptin in fat regulation. Nature 380, 677 (1996).
48. Haynes, W. G., Morgan, D. A., Walsh, S. A., Mark, A. L. & Sivitz, W. I. receptor-mediated regional sympathetic nerve activation by leptin. J. Clin. Invest. 100, 270-278 (1997).
49. rothwell, N. J., Stock, M. J. & Tyzbir, R. S. Energy balance and mitochondrial function in liver and brown fat of rats fed "cafeteria" diets of varying protein content. J. Nutr. 112, 1663-1672 (1982).
50. Rothwell, N. J., Stock, M. J. & Tyzbir, R. S. Mechanisms of thermogenesis induced by low protein diets. Metabolism 32, 257-261 (1983).
51. Lean, M. E. J. & James, W. P. T. in Brown Adipose Tissue (eds Trayhurn, P. & Nicholls, D. G.) 339-365 (Arnold, London, 1986).
52. Heaton, J. M. The distribution of brown adipose tissue in the human. J. Anat. 112, 35-39 (1972).
53. Huttunen, P., Hirvonen, J. & Kinnula, V. The occurrence of brown adipose tissue in outdoor workers. Eur. J. Appl. Physiol. Occup. Physiol. 46, 339-345 (1981).
54. English, J. T., Patel, S. K. & Flanagan, M. J. Association of pheochromocytomas with brown fat tumors. Radiology 107, 279-281 (1973).
55. Sutherland, J. C., Callahan, W. P. Jr & Campbell, G. L. Hibernoma: a tumor of brown fat. Cancer 5, 364-368 (1952).
56. Nedergaard, J., Bengtsson, T. & Cannon, B. Unexpected evidence for active brown adipose tissue in adult humans. Am. J. Physiol. Endocrinol. Metab. 293, E444-E452 (2007).
57. Soderlund, V., Larsson, S. A. & Jacobsson, H. Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol. Eur. J. Nucl. Med. Mol. Imaging 34, 1018-1022 (2007).
58. Christensen, C. R., Clark, P. B. & Morton, K. A. Reversal of hypermetabolic brown adipose tissue in F-18 FDG PET imaging. Clin. Nucl. Med. 31, 193-196 (2006).
59. virtanen, K. A. et al. Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 360, 1518-1525 (2009).
60. Zingaretti, M. C. et al. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J. 23, 3113-3120 (2009).
61. Cypess, A. M. et al. Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 360, 1509-1517 (2009).
62. van Marken Lichtenbelt, W. D. et al. Cold-activated brown adipose tissue in healthy men. N. Engl. J. Med. 360, 1500-1508 (2009).
63. Saito, M. et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58, 1526-1531 (2009).
64. Au-Yong, I. T., Thorn, N., Ganatra, R., Perkins, A. C. & Symonds, M. E. Brown adipose tissue and seasonal variation in humans. Diabetes 58, 2583-2587 (2009).
65. Cohade, C., Mourtzikos, K. A. & Wahl, R. L. "USA-Fat": prevalence is related to ambient outdoor temperature-evaluation with 18F-FDG PET/CT. J. Nucl. Med. 44, 1267-1270 (2003).
66. Rothwell, N. J. & Stock, M. J. Luxuskonsumption, diet-induced thermogenesis and brown fat: the case in favor. Clin. Sci. (Lond.) 64, 19-23 (1983).
67. Ma, S. W. & Foster, D. O. Uptake of glucose and release of fatty acids and glycerol by rat brown adipose tissue in vivo. Can. J. Physiol. Pharmacol. 64, 609-614 (1986).
68. Sramkova, D. et al. The UCP1 gene polymorphism A-3826G in relation to DM2 and body composition in Czech population. Exp. Clin. Endocrinol. Diabetes 115, 303-307 (2007).
69. Fujisawa, T., Ikegami, H., Kawaguchi, Y. & Ogihara, T. Meta-analysis of the association of Trp64Arg polymorphism of beta 3-adrenergic receptor gene with body mass index. J. Clin. Endocrinol. Metab. 83, 2441-2444 (1998).
70. Kurokawa, N. et al. The ADrB3 Trp64Arg variant and BMI: a meta-analysis of 44 833 individuals. Int. J. Obes. (Lond.) 32, 1240-1249 (2008).
71. Feldmann, H. M., Golozoubova, v., Cannon, B. & Nedergaard, J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 9, 203-209 (2009).
72. Allegra, S. R., Gmuer, C. & O'Leary, G. P. Jr. Endocrine activity in a large hibernoma. Hum. Pathol. 14, 1044-1052 (1983).
73. Arch, J. R. et al. Atypical beta-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 309, 163-165 (1984).
74. Bousquet-Melou, A., Galitzky, J., Carpene, C., Lafontan, M. & Berlan, M. Beta-adrenergic control of lipolysis in primate white fat cells: a comparative study with nonprimate mammals. Am. J. Physiol. 267, r115-r123 (1994).
75. Langin, D. Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome. Pharmacol. Res. 53, 482-491 (2006).
76. Spiegelman, B. M. PPAr-gamma: adipogenic regulator and thiazolidinedione receptor. Diabetes 47, 507-514 (1998).
77. Wilson-Fritch, L. et al. Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J. Clin. Invest. 114, 1281-1289 (2004).
78. Tran, T. T. & Kahn, C. R. Transplantation of adipose tissue and stem cells: role in metabolism and disease. Nat. Rev. Endocrinol. 6, 195-213 (2010).