Yeast cells expressing the human mitochondrial dna polymerase reveal correlations between polymerase fidelity and human disease progression

Journal of Biological Chemistry

Volumn 289, Issue 9, 2014, Pages 5970-5985

  Qian, Yufeng ^a   Kachroo, Aashiq H ^a   Yellman, Christopher M ^a   Marcotte, Edward M ^a   Johnson, Kenneth A ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AEROBIC RESPIRATION; FUNDAMENTAL MECHANISMS; HUMAN MITOCHONDRIAL DNA POLYMERASE; MITOCHONDRIAL DISORDERS; MITOCHONDRIAL DNA (MTDNA); MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL MEMBRANES; POLYMERASE FIDELITY;

CELL MEMBRANES; DEFECTS; DNA; MITOCHONDRIA; REPAIR; YEAST;

POLYMERS;

DNA DIRECTED DNA POLYMERASE GAMMA; DNA POLYMERASE; MITOCHONDRIAL DNA; MITOCHONDRIAL DNA POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DIPLOIDY; DISEASE COURSE; DNA CONTENT; ENZYME ACTIVITY; ENZYME ASSAY; FUNGAL GENE; FUNGAL STRAIN; FUNGUS IDENTIFICATION; GENE EXPRESSION; GENE FUNCTION; IN VITRO STUDY; IN VIVO STUDY; MIP1 GENE; MITOCHONDRIAL DNA DEPLETION; MOLECULAR DYNAMICS; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN INTERACTION; REPLISOME; SACCHAROMYCES CEREVISIAE; WILD TYPE; YEAST CELL;

DNA POLYMERASE; DNA REPLICATION; HUMAN MITOCHONDRIA; MITOCHONDRIAL DNA; NUCLEIC ACID ENZYMOLOGY; YEAST;

AMINO ACID SUBSTITUTION; DIFFUSE CEREBRAL SCLEROSIS OF SCHILDER; DNA REPLICATION; DNA, FUNGAL; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; MUTATION, MISSENSE; SACCHAROMYCES CEREVISIAE;

EID: 84896852829     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.526418     Document Type: Article

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