-
2
-
-
0030744876
-
Mutation in the α-synuclein gene identified in families with Parkinson's disease
-
DOI 10.1126/science.276.5321.2045
-
Polymeropoulos M. H., Lavedan C., Leroy E., Ide S. E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E. S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W. G., Lazzarini A. M., Duvoisin R. C., Di Iorio G., Golbe L. I., Nussbaum R. L., Mutation in the α -synuclein gene identified in families with Parkinson's disease. Science 1997 276 5321 2045 2047 2-s2.0-0030744876 10.1126/science.276.5321.2045 (Pubitemid 27443610)
-
(1997)
Science
, vol.276
, Issue.5321
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
Stenroos, E.S.11
Chandrasekharappa, S.12
Athanassiadou, A.13
Papapetropoulos, T.14
Johnson, W.G.15
Lazzarini, A.M.16
Duvoisin, R.C.17
Di Iorio, G.18
Golbe, L.I.19
Nussbaum, R.L.20
more..
-
3
-
-
0031990490
-
Ala30Pro mutation in the gene encoding α -synuclein in Parkinson's disease
-
2-s2.0-0031990490
-
Krüger R., Kuhn W., Müller T., Woitalla D., Graeber M., Kösel S., Przuntek H., Epplen J. T., Schöls L., Riess O., Ala30Pro mutation in the gene encoding α -synuclein in Parkinson's disease. Nature Genetics 1998 18 2 106 108 2-s2.0-0031990490
-
(1998)
Nature Genetics
, vol.18
, Issue.2
, pp. 106-108
-
-
Krüger, R.1
Kuhn, W.2
Müller, T.3
Woitalla, D.4
Graeber, M.5
Kösel, S.6
Przuntek, H.7
Epplen, J.T.8
Schöls, L.9
Riess, O.10
-
4
-
-
10744230149
-
The new mutation, E46k, of α-synuclein causes parkinson and lewy body dementia
-
DOI 10.1002/ana.10795
-
Zarranz J. J., Alegre J., Gómez-Esteban J. C., Lezcano E., Ros R., Ampuero I., Vidal L., Hoenicka J., Rodriguez O., Atarés B., Llorens V., Gomez Tortosa E., Del Ser T., Muñoz D. G., De Yebenes J. G., The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Annals of Neurology 2004 55 2 164 173 2-s2.0-10744230149 10.1002/ana.10795 (Pubitemid 38166992)
-
(2004)
Annals of Neurology
, vol.55
, Issue.2
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gomez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
Ampuero, I.6
Vidal, L.7
Hoenicka, J.8
Rodriguez, O.9
Atares, B.10
Llorens, V.11
Gomez Tortosa, E.12
Del Ser, T.13
Munoz, D.G.14
De Yebenes, J.G.15
-
5
-
-
4644290985
-
α-synuclein locus duplication as a cause of familial Parkinson's disease
-
DOI 10.1016/S0140-6736(04)17103-1, PII S0140673604171031
-
Chartier-Harlin M.-C., Kachergus J., Roumier C., Mouroux V., Douay X., Lincoln S., Levecque C., Larvor L., Andrieux J., Hulihan M., Waucquier N., Defebvre L., Amouyel P., Farrer M., Destée A., α -synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 2004 364 9440 1167 1169 2-s2.0-4644290985 10.1016/S0140-6736(04)17103-1 (Pubitemid 39296604)
-
(2004)
Lancet
, vol.364
, Issue.9440
, pp. 1167-1169
-
-
Chartier-Harlin, M.-C.1
Kachergus, J.2
Roumier, C.3
Mouroux, V.4
Douay, X.5
Lincoln, S.6
Levecque, C.7
Larvor, L.8
Andrieux, J.9
Hulihan, M.10
Waucquier, N.11
Defebvre, L.12
Amouyel, P.13
Farrer, M.14
Destee, A.15
-
6
-
-
4644236043
-
Causal relation between α-synuclein gene duplication and familial Parkinson's disease
-
DOI 10.1016/S0140-6736(04)17104-3, PII S0140673604171043
-
Ibáñez P., Bonnet A.-M., Débarges B., Lohmann E., Tison F., Pollak P., Agid Y., Dürr A., Brice P. A., Causal relation between α -synuclein gene duplication and familial Parkinson's disease. Lancet 2004 364 9440 1169 1171 2-s2.0-4644236043 10.1016/S0140-6736(04)17104-3 (Pubitemid 39296605)
-
(2004)
Lancet
, vol.364
, Issue.9440
, pp. 1169-1171
-
-
Ibanez, P.1
Bonnet, A.-M.2
Debarges, B.3
Lohmann, E.4
Tison, F.5
Pollak, P.6
Agid, Y.7
Durr, A.8
Brice, P.A.9
-
7
-
-
0242300619
-
α-synuclein locus triplication causes parkinson's disease
-
DOI 10.1126/science.1090278
-
Singleton A. B., Farrer M., Johnson J., Singleton A., Hague S., Kachergus J., Hulihan M., Peuralinna T., Dutra A., Nussbaum R., Lincoln S., Crawley A., Hanson M., Maraganore D., Adler C., Cookson M. R., Muenter M., Baptista M., Miller D., Blancato J., Hardy J., Gwinn-Hardy K., alpha-Synuclein locus triplication causes Parkinson's disease. Science 2003 302 5646 841 2-s2.0-0242300619 10.1126/science.1090278 (Pubitemid 37339619)
-
(2003)
Science
, vol.302
, Issue.5646
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
Lincoln, S.11
Crawley, A.12
Hanson, M.13
Maraganore, D.14
Adler, C.15
Cookson, M.R.16
Muenter, M.17
Baptista, M.18
Miller, D.19
Blancato, J.20
Hardy, J.21
Gwinn-Hardy, K.22
more..
-
8
-
-
0031941058
-
Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
-
Baba M., Nakajo S., Tu P.-H., Tomita T., Nakaya K., Lee V. M.-Y., Trojanowski J. Q., Iwatsubo T., Aggregation of α -synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. American Journal of Pathology 1998 152 4 879 884 2-s2.0-0031941058 (Pubitemid 28173348)
-
(1998)
American Journal of Pathology
, vol.152
, Issue.4
, pp. 879-884
-
-
Baba, M.1
Nakajo, S.2
Tu, P.-H.3
Tomita, T.4
Nakaya, K.5
Lee, V.M.-Y.6
Trojanowski, J.Q.7
Iwatsubo, T.8
-
9
-
-
0032952414
-
Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions
-
DOI 10.1038/8820
-
Engelender S., Kaminsky Z., Xin G., Sharp A. H., Amaravi R. K., Kleiderlein J. J., Margolis R. L., Troncoso J. C., Lanahan A. A., Worley P. F., Dawson V. L., Dawson T. M., Ross C. A., Synphilin-1 associates with α -synuclein and promotes the formation of cytosolic inclusions. Nature Genetics 1999 22 1 110 114 2-s2.0-0032952414 10.1038/8820 (Pubitemid 29214817)
-
(1999)
Nature Genetics
, vol.22
, Issue.1
, pp. 110-114
-
-
Engelender, S.1
Kaminsky, Z.2
Xin, G.3
Sharp, A.H.4
Amaravi, R.K.5
Kleiderlein, J.J.6
Margolis, R.L.7
Troncoso, J.C.8
Lanahan, A.A.9
Worley, P.F.10
Dawson, V.L.11
Dawson, T.M.12
Ross, C.A.13
-
10
-
-
0034085796
-
Synphilin-1 is present in lewy bodies in Parkinson's disease
-
DOI 10.1002/1531-8249(200004)47:4 <521::AID-ANA18>3.0.CO;2-B
-
Wakabayashi K., Engelender S., Yoshimoto M., Tsuji S., Ross C. A., Takahashi H., Synphilin-1 is present in Lewy bodies in Parkinson's disease. Annals of Neurology 2000 47 521 523 (Pubitemid 30194611)
-
(2000)
Annals of Neurology
, vol.47
, Issue.4
, pp. 521-523
-
-
Wakabayashi, K.1
Engelender, S.2
Yoshimoto, M.3
Tsuji, S.4
Ross, C.A.5
Takahashi, H.6
-
11
-
-
0030768919
-
Yeast as a model organism
-
DOI 10.1126/science.277.5330.1259
-
Botstein D., Chervitz S. A., Cherry J. M., Yeast as a model organism. Science 1997 277 5330 1259 1260 2-s2.0-0030768919 10.1126/science.277.5330.1259 (Pubitemid 27449069)
-
(1997)
Science
, vol.277
, Issue.5330
, pp. 1259-1260
-
-
Botstein, D.1
Chervitz, S.A.2
Cherry, J.M.3
-
12
-
-
0030033794
-
Yeast genes and human disease [2]
-
DOI 10.1038/379589a0
-
Bassett D. E. Jr., Boguski M. S., Hieter P., Yeast genes and human disease. Nature 1996 379 6566 589 590 2-s2.0-0030033794 10.1038/379589a0 (Pubitemid 26052815)
-
(1996)
Nature
, vol.379
, Issue.6566
, pp. 589-590
-
-
Bassett Jr., D.E.1
Boguski, M.S.2
Hieter, P.3
-
13
-
-
0036275447
-
Getting started with yeast
-
DOI 10.1016/S0076-6879(02)50954-X
-
Sherman F., Getting started with yeast. Methods in Enzymology 2002 350 3 41 2-s2.0-0036275447 10.1016/S0076-6879(02)50954-X (Pubitemid 34619482)
-
(2002)
Methods in Enzymology
, vol.350
, pp. 3-41
-
-
Sherman, F.1
-
14
-
-
0033529707
-
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis
-
DOI 10.1126/science.285.5429.901
-
Winzeler E. A., Shoemaker D. D., Astromoff A., Liang H., Anderson K., Andre B., Bangham R., Benito R., Boeke J. D., Bussey H., Chu A. M., Connelly C., Davis K., Dietrich F., Dow S. W., El Bakkoury M., Foury F., Friend S. H., Gentalen E., Giaever G., Hegemann J. H., Jones T., Laub M., Liao H., Liebundguth N., Lockhart D. J., Lucau-Danila A., Lussier M., M'Rabet N., Menard P., Mittmann M., Pai C., Rebischung C., Revuelta J. L., Riles L., Roberts C. J., Ross-MacDonald P., Scherens B., Snyder M., Sookhai-Mahadeo S., Storms R. K., Véronneau S., Voet M., Volckaert G., Ward T. R., Wysocki R., Yen G. S., Yu K., Zimmermann K., Philippsen P., Johnston M., Davis R. W., Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 1999 285 5429 901 906 2-s2.0-0033529707 10.1126/science.285. 5429.901 (Pubitemid 29381993)
-
(1999)
Science
, vol.285
, Issue.5429
, pp. 901-906
-
-
Winzeler, E.A.1
Shoemaker, D.D.2
Astromoff, A.3
Liang, H.4
Anderson, K.5
Andre, B.6
Bangham, R.7
Benito, R.8
Boeke, J.D.9
Bussey, H.10
Chu, A.M.11
Connelly, C.12
Davis, K.13
Dietrich, F.14
Dow, S.W.15
El Bakkoury, M.16
Foury, F.17
Friend, S.H.18
Gentalen, E.19
Giaever, G.20
Hegemann, J.H.21
Jones, T.22
Laub, M.23
Liao, H.24
Liebundguth, N.25
Lockhart, D.J.26
Lucau-Danila, A.27
Lussier, M.28
M'Rabet, N.29
Menard, P.30
Mittmann, M.31
Pai, C.32
Rebischung, C.33
Revuelta, J.L.34
Riles, L.35
Roberts, C.J.36
Ross-MacDonald, P.37
Scherens, B.38
Snyder, M.39
Sookhai-Mahadeo, S.40
Storms, R.K.41
Veronneau, S.42
Voet, M.43
Volckaert, G.44
Ward, T.R.45
Wysocki, R.46
Yen, G.S.47
Yu, K.48
Zimmermann, K.49
Philippsen, P.50
Johnston, M.51
Davis, R.W.52
more..
-
15
-
-
3142536716
-
Exploration of essential gene functions via titratable promoter alleles
-
DOI 10.1016/j.cell.2004.06.013, PII S0092867404005811
-
Mnaimneh S., Davierwala A. P., Haynes J., Moffat J., Peng W.-T., Zhang W., Yang X., Pootoolal J., Chua G., Lopez A., Trochesset M., Morse D., Krogan N. J., Hiley S. L., Li Z., Morris Q., Grigull J., Mitsakakis N., Roberts C. J., Greenblatt J. F., Boone C., Kaiser C. A., Andrews B. J., Hughes T. R., Exploration of essential gene functions via titratable promoter alleles. Cell 2004 118 1 31 44 2-s2.0-3142536716 10.1016/j.cell.2004.06.013 (Pubitemid 38902812)
-
(2004)
Cell
, vol.118
, Issue.1
, pp. 31-44
-
-
Mnaimneh, S.1
Davierwala, A.P.2
Haynes, J.3
Moffat, J.4
Peng, W.-T.5
Zhang, W.6
Yang, X.7
Pootoolal, J.8
Chua, G.9
Lopez, A.10
Trochesset, M.11
Morse, D.12
Krogan, N.J.13
Hiley, S.L.14
Li, Z.15
Morris, Q.16
Grigull, J.17
Mitsakakis, N.18
Roberts, C.J.19
Greenblatt, J.F.20
Boone, C.21
Kaiser, C.A.22
Andrews, B.J.23
Hughes, T.R.24
more..
-
16
-
-
34147092780
-
Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae
-
DOI 10.1101/gr.6037607
-
Hu Y., Rolfs A., Bhullar B., Murthy T. V. S., Zhu C., Berger M. F., Camargo A. A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M. F., Williamson J., Simpson A., Bulyk M. L., Harlow E., Marsischky G., Kolodner R. D., LaBaer J., Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae. Genome Research 2007 17 4 536 543 2-s2.0-34147092780 10.1101/gr.6037607 (Pubitemid 46556458)
-
(2007)
Genome Research
, vol.17
, Issue.4
, pp. 536-543
-
-
Hu, Y.1
Rolfs, A.2
Bhullar, B.3
Murthy, T.V.S.4
Zhu, C.5
Berger, M.F.6
Camargo, A.A.7
Kelley, F.8
McCarron, S.9
Jepson, D.10
Richardson, A.11
Raphael, J.12
Moreira, D.13
Taycher, E.14
Zuo, D.15
Mohr, S.16
Kane, M.F.17
Williamson, J.18
Simpson, A.19
Bulyk, M.L.20
Harlow, E.21
Marsischky, G.22
Kolodner, R.D.23
LaBaer, J.24
more..
-
17
-
-
0033527694
-
A biochemical genomics approach for identifying genes by the activity of their products
-
DOI 10.1126/science.286.5442.1153
-
Martien M. R., McCraith S. M., Spinelli S. L., Torres F. M., Fields S., Grayhack E. J., Phizicky E. M., A biochemical genomics approach for identifying genes by the activity of their products. Science 1999 286 5442 1153 1155 2-s2.0-0033527694 10.1126/science.286.5442.1153 (Pubitemid 29522275)
-
(1999)
Science
, vol.286
, Issue.5442
, pp. 1153-1155
-
-
Martien, M.R.1
McCraith, S.M.2
Spinelli, S.L.3
Torres, F.M.4
Fields, S.5
Grayhack, E.J.6
Phizicky, E.M.7
-
18
-
-
0345189364
-
Yeast cells provide insight into alpha-synuclein biology and pathobiology
-
DOI 10.1126/science.1090439
-
Outeiro T. F., Lindquist S., Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science 2003 302 5651 1772 1775 2-s2.0-0345189364 10.1126/science.1090439 (Pubitemid 37505742)
-
(2003)
Science
, vol.302
, Issue.5651
, pp. 1772-1775
-
-
Outeiro, T.F.1
Lindquist, S.2
-
19
-
-
0034602296
-
α -Synuclein membrane interactions and lipid specificity
-
2-s2.0-0034602296
-
Jo E., McLaurin J., Yip C. M., St. George-Hyslop P., Fraser P. E., α -Synuclein membrane interactions and lipid specificity. Journal of Biological Chemistry 2000 275 44 34328 34334 2-s2.0-0034602296
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.44
, pp. 34328-34334
-
-
Jo, E.1
McLaurin, J.2
Yip, C.M.3
St. George-Hyslop, P.4
Fraser, P.E.5
-
20
-
-
0345189365
-
Yeast Genes that Enhance the Toxicity of a Mutant Huntingtin Fragment or α-Synuclein
-
DOI 10.1126/science.1090389
-
Willingham S., Outeiro T. F., DeVit M. J., Lindquist S. L., Muchowski P. J., Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science 2003 302 5651 1769 1772 2-s2.0-0345189365 10.1126/science.1090389 (Pubitemid 37505741)
-
(2003)
Science
, vol.302
, Issue.5651
, pp. 1769-1772
-
-
Willingham, S.1
Outeiro, T.F.2
DeVit, M.J.3
Lindquist, S.L.4
Muchowski, P.J.5
-
21
-
-
56049117969
-
Novel suppressors of α -synuclein toxicity identified using yeast
-
2-s2.0-56049117969 10.1093/hmg/ddn276
-
Liang J., Clark-Dixon C., Wang S., Flower T. R., Williams-Hart T., Zweig R., Robinson L. C., Tatchell K., Witt S. N., Novel suppressors of α -synuclein toxicity identified using yeast. Human Molecular Genetics 2008 17 23 3784 3795 2-s2.0-56049117969 10.1093/hmg/ddn276
-
(2008)
Human Molecular Genetics
, vol.17
, Issue.23
, pp. 3784-3795
-
-
Liang, J.1
Clark-Dixon, C.2
Wang, S.3
Flower, T.R.4
Williams-Hart, T.5
Zweig, R.6
Robinson, L.C.7
Tatchell, K.8
Witt, S.N.9
-
22
-
-
61349114190
-
Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity
-
2-s2.0-61349114190 10.1038/ng.337
-
Yeger-Lotem E., Riva L., Su L. J., Gitler A. D., Cashikar A. G., King O. D., Auluck P. K., Geddie M. L., Valastyan J. S., Karger D. R., Lindquist S., Fraenkel E., Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Nature Genetics 2009 41 3 316 323 2-s2.0-61349114190 10.1038/ng.337
-
(2009)
Nature Genetics
, vol.41
, Issue.3
, pp. 316-323
-
-
Yeger-Lotem, E.1
Riva, L.2
Su, L.J.3
Gitler, A.D.4
Cashikar, A.G.5
King, O.D.6
Auluck, P.K.7
Geddie, M.L.8
Valastyan, J.S.9
Karger, D.R.10
Lindquist, S.11
Fraenkel, E.12
-
23
-
-
50849130565
-
Phosphorylation, lipid raft interaction and traffic of α -synuclein in a yeast model for Parkinson
-
2-s2.0-50849130565 10.1016/j.bbamcr.2008.06.010
-
Zabrocki P., Bastiaens I., Delay C., Bammens T., Ghillebert R., Pellens K., De Virgilio C., Van Leuven F., Winderickx J., Phosphorylation, lipid raft interaction and traffic of α -synuclein in a yeast model for Parkinson. Biochimica et Biophysica Acta 2008 1783 10 1767 1780 2-s2.0-50849130565 10.1016/j.bbamcr.2008.06.010
-
(2008)
Biochimica et Biophysica Acta
, vol.1783
, Issue.10
, pp. 1767-1780
-
-
Zabrocki, P.1
Bastiaens, I.2
Delay, C.3
Bammens, T.4
Ghillebert, R.5
Pellens, K.6
De Virgilio, C.7
Van Leuven, F.8
Winderickx, J.9
-
24
-
-
78149449581
-
Synphilin-1 enhances a-synuclein aggregation in yeast and contributes to cellular stress and cell death in a sir2-dependent manner
-
2-s2.0-78149449581 10.1371/journal.pone.0013700 e13700
-
Büttner S., Delay C., Franssens V., Bammens T., Ruli D., Zaunschirm S., de Oliveira R. M., Outeiro T. F., Madeo F., Buée L., Galas M.-C., Winderickx J., Synphilin-1 enhances a-synuclein aggregation in yeast and contributes to cellular stress and cell death in a sir2-dependent manner. PLoS One 2010 5 10 2-s2.0-78149449581 10.1371/journal.pone.0013700 e13700
-
(2010)
PLoS One
, vol.5
, Issue.10
-
-
Büttner, S.1
Delay, C.2
Franssens, V.3
Bammens, T.4
Ruli, D.5
Zaunschirm, S.6
De Oliveira, R.M.7
Outeiro, T.F.8
Madeo, F.9
Buée, L.10
Galas, M.-C.11
Winderickx, J.12
-
25
-
-
15944378475
-
Characterization of α-synuclein aggregation and synergistic toxicity with protein tau in yeast
-
DOI 10.1111/j.1742-4658.2005.04571.x
-
Zabrocki P., Pellens K., Vanhelmont T., Vandebroek T., Griffioen G., Wera S., Van Leuven F., Winderickx J., Characterization of α -synuclein aggregation and synergistic toxicity with protein tau in yeast. FEBS Journal 2005 272 6 1386 1400 2-s2.0-15944378475 10.1111/j.1742-4658.2005.04571.x (Pubitemid 40444929)
-
(2005)
FEBS Journal
, vol.272
, Issue.6
, pp. 1386-1400
-
-
Zabrocki, P.1
Pellens, K.2
Vanhelmont, T.3
Vandebroek, T.4
Griffioen, G.5
Wera, S.6
Van Leuven, F.7
Winderickx, J.8
-
26
-
-
0035910634
-
Proteasomal function is impaired in substantia nigra in Parkinson's disease
-
DOI 10.1016/S0304-3940(00)01701-8, PII S0304394000017018
-
McNaught K. S., Jenner P., Proteasomal function is impaired in substantia nigra in Parkinson's disease. Neuroscience Letters 2001 297 3 191 194 2-s2.0-0035910634 10.1016/S0304-3940(00)01701-8 (Pubitemid 32011306)
-
(2001)
Neuroscience Letters
, vol.297
, Issue.3
, pp. 191-194
-
-
McNaught, K.St.P.1
Jenner, P.2
-
27
-
-
0023793690
-
Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases
-
2-s2.0-0023793690
-
Manetto V., Perry G., Tabaton M., Mulvihill P., Fried V. A., Smith H. T., Gambetti P., Autilio-Gambetti L., Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases. Proceedings of the National Academy of Sciences of the United States of America 1988 85 12 4501 4505 2-s2.0-0023793690
-
(1988)
Proceedings of the National Academy of Sciences of the United States of America
, vol.85
, Issue.12
, pp. 4501-4505
-
-
Manetto, V.1
Perry, G.2
Tabaton, M.3
Mulvihill, P.4
Fried, V.A.5
Smith, H.T.6
Gambetti, P.7
Autilio-Gambetti, L.8
-
28
-
-
0023682738
-
Lewy bodies contain epitopes both shared and distinct from Alzheimer neurofibrillary tangles
-
2-s2.0-0023682738
-
Galloway P. G., Grundke-Iqbal I., Iqbal K., Perry G., Lewy bodies contain epitopes both shared and distinct from Alzheimer neurofibrillary tangles. Journal of Neuropathology and Experimental Neurology 1988 47 6 654 663 2-s2.0-0023682738
-
(1988)
Journal of Neuropathology and Experimental Neurology
, vol.47
, Issue.6
, pp. 654-663
-
-
Galloway, P.G.1
Grundke-Iqbal, I.2
Iqbal, K.3
Perry, G.4
-
29
-
-
24044516868
-
α-synuclein alters proteasome function, protein synthesis, and stationary phase viability
-
DOI 10.1074/jbc.M501308200
-
Chen Q., Thorpe J., Keller J. N., α -synuclein alters proteasome function, protein synthesis, and stationary phase viability. Journal of Biological Chemistry 2005 280 34 30009 30017 2-s2.0-24044516868 10.1074/jbc.M501308200 (Pubitemid 41216176)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.34
, pp. 30009-30017
-
-
Chen, Q.1
Thorpe, J.2
Keller, J.N.3
-
30
-
-
33646885472
-
α-synuclein budding yeast model: Toxicity enhanced by impaired proteasome and oxidative stress
-
DOI 10.1385/JMN:28:2:161
-
Sharma N., Brandis K. A., Herrera S. K., Johnson B. E., Vaidya T., Shrestha R., DebBurman S. K., α -synuclein budding yeast model: toxicity enhanced by impaired proteasome and oxidative stress. Journal of Molecular Neuroscience 2006 28 2 161 178 2-s2.0-33646885472 10.1385/JMN:28:2:161 (Pubitemid 43780329)
-
(2006)
Journal of Molecular Neuroscience
, vol.28
, Issue.2
, pp. 161-178
-
-
Sharma, N.1
Brandis, K.A.2
Herrera, S.K.3
Johnson, B.E.4
Vaidya, T.5
Shrestha, R.6
DebBurman, S.K.7
-
31
-
-
20444372698
-
α-synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast
-
DOI 10.1534/genetics.104.035493
-
Dixon C., Mathias N., Zweig R. M., Davis D. A., Gross D. S., α -Synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast. Genetics 2005 170 1 47 59 2-s2.0-20444372698 10.1534/genetics.104.035493 (Pubitemid 40799970)
-
(2005)
Genetics
, vol.170
, Issue.1
, pp. 47-59
-
-
Dixon, C.1
Mathias, N.2
Zweig, R.M.3
Davis, D.A.4
Gross, D.S.5
-
32
-
-
84864979359
-
Aggregate clearance of alpha-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome
-
Petroi D., Popova B., Taheri-Talesh N., Irniger S., Shahpasandzadeh H., Zweckstetter M., Outeiro T. F., Braus G. H., Aggregate clearance of alpha-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome. The Journal of Biological Chemistry 2012 287 27567 27579
-
(2012)
The Journal of Biological Chemistry
, vol.287
, pp. 27567-27579
-
-
Petroi, D.1
Popova, B.2
Taheri-Talesh, N.3
Irniger, S.4
Shahpasandzadeh, H.5
Zweckstetter, M.6
Outeiro, T.F.7
Braus, G.H.8
-
33
-
-
0041589248
-
α-synuclein Is Degraded by Both Autophagy and the Proteasome
-
DOI 10.1074/jbc.M300227200
-
Webb J. L., Ravikumar B., Atkins J., Skepper J. N., Rubinsztein D. C., Alpha-Synuclein is degraded by both autophagy and the proteasome. Journal of Biological Chemistry 2003 278 27 25009 25013 2-s2.0-0041589248 10.1074/jbc.M300227200 (Pubitemid 37548663)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.27
, pp. 25009-25013
-
-
Webb, J.L.1
Ravikumar, B.2
Atkins, J.3
Skepper, J.N.4
Rubinsztein, D.C.5
-
34
-
-
41549114279
-
The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease
-
2-s2.0-41549114279 10.1093/brain/awm318
-
Pan T., Kondo S., Le W., Jankovic J., The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease. Brain 2008 131 8 1969 1978 2-s2.0-41549114279 10.1093/brain/awm318
-
(2008)
Brain
, vol.131
, Issue.8
, pp. 1969-1978
-
-
Pan, T.1
Kondo, S.2
Le, W.3
Jankovic, J.4
-
35
-
-
84869039156
-
Protein clearance mechanisms of alpha-synuclein and amyloid-Beta in lewy body disorders
-
391438 10.1155/2012/391438
-
Deleidi M., Maetzler W., Protein clearance mechanisms of alpha-synuclein and amyloid-Beta in lewy body disorders. International Journal of Alzheimer's Disease 2012 2012 9 391438 10.1155/2012/391438
-
(2012)
International Journal of Alzheimer's Disease
, vol.2012
, pp. 9
-
-
Deleidi, M.1
Maetzler, W.2
-
36
-
-
61349147706
-
α -Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity
-
2-s2.0-61349147706 10.1038/ng.300
-
Gitler A. D., Chesi A., Geddie M. L., Strathearn K. E., Hamamichi S., Hill K. J., Caldwell K. A., Caldwell G. A., Cooper A. A., Rochet J.-C., Lindquist S., α -Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nature Genetics 2009 41 3 308 315 2-s2.0-61349147706 10.1038/ng.300
-
(2009)
Nature Genetics
, vol.41
, Issue.3
, pp. 308-315
-
-
Gitler, A.D.1
Chesi, A.2
Geddie, M.L.3
Strathearn, K.E.4
Hamamichi, S.5
Hill, K.J.6
Caldwell, K.A.7
Caldwell, G.A.8
Cooper, A.A.9
Rochet, J.-C.10
Lindquist, S.11
-
37
-
-
34250723888
-
YGR198w (YPP1) targets A30P α-synuclein to the vacuole for degradation
-
DOI 10.1083/jcb.200610071
-
Flower T. R., Clark-Dixon C., Metoyer C., Yang H., Shi R., Zhang Z., Witt S. N., YGR198w (YPP1) targets A30P α -synuclein to the vacuole for degradation. Journal of Cell Biology 2007 177 6 1091 1104 2-s2.0-34250723888 10.1083/jcb.200610071 (Pubitemid 46955712)
-
(2007)
Journal of Cell Biology
, vol.177
, Issue.6
, pp. 1091-1104
-
-
Flower, T.R.1
Clark-Dixon, C.2
Metoyer, C.3
Yang, H.4
Shi, R.5
Zhang, Z.6
Witt, S.N.7
-
38
-
-
0033681149
-
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
-
2-s2.0-0033681149 10.1038/81834
-
Betarbet R., Sherer T. B., MacKenzie G., Garcia-Osuna M., Panov A. V., Greenamyre J. T., Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nature Neuroscience 2000 3 12 1301 1306 2-s2.0-0033681149 10.1038/81834
-
(2000)
Nature Neuroscience
, vol.3
, Issue.12
, pp. 1301-1306
-
-
Betarbet, R.1
Sherer, T.B.2
MacKenzie, G.3
Garcia-Osuna, M.4
Panov, A.V.5
Greenamyre, J.T.6
-
39
-
-
0020680904
-
Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
-
Langston J. W., Ballard P., Tetrud J. W., Irwin I., Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1983 219 4587 979 980 2-s2.0-0020680904 (Pubitemid 13189531)
-
(1983)
Science
, vol.219
, Issue.4587
, pp. 979-980
-
-
Langston, J.W.1
Ballard, P.2
Tetrud, J.W.3
Irwin, I.4
-
40
-
-
0030878320
-
Environmental risk factors and Parkinson's disease: A case-control study in Taiwan
-
2-s2.0-0030878320
-
Liou H.-H., Tsai M. C., Chen C. J., Jeng J. S., Chang Y. C., Chen S. Y., Chen R. C., Environmental risk factors and Parkinson's disease: a case-control study in Taiwan. Neurology 1997 48 6 1583 1588 2-s2.0-0030878320
-
(1997)
Neurology
, vol.48
, Issue.6
, pp. 1583-1588
-
-
Liou, H.-H.1
Tsai, M.C.2
Chen, C.J.3
Jeng, J.S.4
Chang, Y.C.5
Chen, S.Y.6
Chen, R.C.7
-
41
-
-
67649756320
-
Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease
-
2-s2.0-67649756320 10.1016/j.expneurol.2009.03.006
-
Büeler H., Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease. Experimental Neurology 2009 218 2 235 246 2-s2.0-67649756320 10.1016/j.expneurol.2009.03.006
-
(2009)
Experimental Neurology
, vol.218
, Issue.2
, pp. 235-246
-
-
Büeler, H.1
-
42
-
-
31644443193
-
A yeast-based model of α-synucleinopathy identifies compounds with therapeutic potential
-
DOI 10.1016/j.bbadis.2005.11.009, PII S092544390500181X
-
Griffioen G., Duhamel H., Van Damme N., Pellens K., Zabrocki P., Pannecouque C., Van Leuven F., Winderickx J., Wera S., A yeast-based model of α -synucleinopathy identifies compounds with therapeutic potential. Biochimica et Biophysica Acta 2006 1762 3 312 318 2-s2.0-31644443193 10.1016/j.bbadis.2005.11.009 (Pubitemid 43172846)
-
(2006)
Biochimica et Biophysica Acta - Molecular Basis of Disease
, vol.1762
, Issue.3
, pp. 312-318
-
-
Griffioen, G.1
Duhamel, H.2
Van Damme, N.3
Pellens, K.4
Zabrocki, P.5
Pannecouque, C.6
Van Leuven, F.7
Winderickx, J.8
Wera, S.9
-
43
-
-
77949438990
-
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models
-
2-s2.0-77949438990 10.1242/dmm.004267
-
Su L. J., Auluck P. K., Outeiro T. F., Yeger-Lotem E., Kritzer J. A., Tardiff D. F., Strathearn K. E., Liu F., Cao S., Hamamichi S., Hill K. J., Caldwell K. A., Bell G. W., Fraenkel E., Cooper A. A., Caldwell G. A., Michael McCaffery J., Rochet J.-C., Lindquist S., Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Disease Models and Mechanisms 2010 3 3-4 194 208 2-s2.0-77949438990 10.1242/dmm.004267
-
(2010)
Disease Models and Mechanisms
, vol.3
, Issue.3-4
, pp. 194-208
-
-
Su, L.J.1
Auluck, P.K.2
Outeiro, T.F.3
Yeger-Lotem, E.4
Kritzer, J.A.5
Tardiff, D.F.6
Strathearn, K.E.7
Liu, F.8
Cao, S.9
Hamamichi, S.10
Hill, K.J.11
Caldwell, K.A.12
Bell, G.W.13
Fraenkel, E.14
Cooper, A.A.15
Caldwell, G.A.16
Michael McCaffery, J.17
Rochet, J.-C.18
Lindquist, S.19
-
44
-
-
43149107699
-
Functional mitochondria are required for α -synuclein toxicity in aging yeast
-
2-s2.0-43149107699 10.1074/jbc.M708477200
-
Büttner S., Bitto A., Ring J., Augsten M., Zabrocki P., Eisenberg T., Jungwirth H., Hutter S., Carmona-Gutierrez D., Kroemer G., Winderickx J., Madeo F., Functional mitochondria are required for α -synuclein toxicity in aging yeast. Journal of Biological Chemistry 2008 283 12 7554 7560 2-s2.0-43149107699 10.1074/jbc.M708477200
-
(2008)
Journal of Biological Chemistry
, vol.283
, Issue.12
, pp. 7554-7560
-
-
Büttner, S.1
Bitto, A.2
Ring, J.3
Augsten, M.4
Zabrocki, P.5
Eisenberg, T.6
Jungwirth, H.7
Hutter, S.8
Carmona-Gutierrez, D.9
Kroemer, G.10
Winderickx, J.11
Madeo, F.12
-
45
-
-
84855474847
-
Mitochondrial dynamics and mitophagy in Parkinson's disease: Disordered cellular power plant becomes a big deal in a major movement disorder
-
2-s2.0-84855474847 10.1016/j.conb.2011.10.016
-
Imai Y., Lu B., Mitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorder. Current Opinion in Neurobiology 2011 21 6 935 941 2-s2.0-84855474847 10.1016/j.conb.2011.10.016
-
(2011)
Current Opinion in Neurobiology
, vol.21
, Issue.6
, pp. 935-941
-
-
Imai, Y.1
Lu, B.2
-
46
-
-
84867280590
-
SNCA (alpha-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy
-
Sampaio-Marques B., Felgueiras C., Silva A., Rodrigues M., Tenreiro S., Franssens V., Reichert A. S., Outeiro T. F., Winderickx J., Ludovico P., SNCA (alpha-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy. Autophagy 2012 8 1494 1509
-
(2012)
Autophagy
, vol.8
, pp. 1494-1509
-
-
Sampaio-Marques, B.1
Felgueiras, C.2
Silva, A.3
Rodrigues, M.4
Tenreiro, S.5
Franssens, V.6
Reichert, A.S.7
Outeiro, T.F.8
Winderickx, J.9
Ludovico, P.10
-
47
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
DOI 10.1038/35001622
-
Imai S.-I., Armstrong C. M., Kaeberlein M., Guarente L., Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000 403 6771 795 800 2-s2.0-0034677535 10.1038/35001622 (Pubitemid 30111843)
-
(2000)
Nature
, vol.403
, Issue.6771
, pp. 795-800
-
-
Imai, S.-I.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
48
-
-
3943054839
-
The Sir2 family of protein deacetylases
-
DOI 10.1146/annurev.biochem.73.011303.073651
-
Blander G., Guarente L., The Sir2 family of protein deacetylases. Annual Review of Biochemistry 2004 73 417 435 2-s2.0-3943054839 10.1146/annurev. biochem.73.011303.073651 (Pubitemid 39050375)
-
(2004)
Annual Review of Biochemistry
, vol.73
, pp. 417-435
-
-
Blander, G.1
Guarente, L.2
-
49
-
-
0034703217
-
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
-
2-s2.0-0034703217 10.1126/science.289.5487.2126
-
Lin S.-J., Defossez P.-A., Guarente L., Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 2000 289 5487 2126 2128 2-s2.0-0034703217 10.1126/science.289.5487.2126
-
(2000)
Science
, vol.289
, Issue.5487
, pp. 2126-2128
-
-
Lin, S.-J.1
Defossez, P.-A.2
Guarente, L.3
-
50
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
DOI 10.1038/35065638
-
Tissenbaum H. A., Guarente L., Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 2001 410 6825 227 230 2-s2.0-0035826271 10.1038/35065638 (Pubitemid 32216597)
-
(2001)
Nature
, vol.410
, Issue.6825
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
51
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
-
DOI 10.1073/pnas.0404184101
-
Rogina B., Helfand S. L., Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proceedings of the National Academy of Sciences of the United States of America 2004 101 45 15998 16003 2-s2.0-8644224064 10.1073/pnas.0404184101 (Pubitemid 39507916)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.45
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
52
-
-
67949102053
-
Recent progress in the biology and physiology of sirtuins
-
2-s2.0-67949102053 10.1038/nature08197
-
Finkel T., Deng C.-X., Mostoslavsky R., Recent progress in the biology and physiology of sirtuins. Nature 2009 460 7255 587 591 2-s2.0-67949102053 10.1038/nature08197
-
(2009)
Nature
, vol.460
, Issue.7255
, pp. 587-591
-
-
Finkel, T.1
Deng, C.-X.2
Mostoslavsky, R.3
-
53
-
-
33749570292
-
Phosphorylation of Ser-129 is the dominant pathological modification of α-synuclein in familial and sporadic lewy body disease
-
DOI 10.1074/jbc.M600933200
-
Anderson J. P., Walker D. E., Goldstein J. M., De Laat R., Banducci K., Caccavello R. J., Barbour R., Huang J., Kling K., Lee M., Diep L., Keim P. S., Shen X., Chataway T., Schlossmacher M. G., Seubert P., Schenk D., Sinha S., Gai W. P., Chilcote T. J., Phosphorylation of Ser-129 is the dominant pathological modification of α -synuclein in familial and sporadic lewy body disease. Journal of Biological Chemistry 2006 281 40 29739 29752 2-s2.0-33749570292 10.1074/jbc.M600933200 (Pubitemid 44536983)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.40
, pp. 29739-29752
-
-
Anderson, J.P.1
Walker, D.E.2
Goldstein, J.M.3
De Laat, R.4
Banducci, K.5
Caccavello, R.J.6
Barbour, R.7
Huang, J.8
Kling, K.9
Lee, M.10
Diep, L.11
Keim, P.S.12
Shen, X.13
Chataway, T.14
Schlossmacher, M.G.15
Seubert, P.16
Schenk, D.17
Sinha, S.18
Gai, W.P.19
Chilcote, T.J.20
more..
-
54
-
-
25444465916
-
The 'Little Ice Age' recorded by sediment chemistry in Lake Erhai, southwest China
-
DOI 10.1191/0959683605hl863rr
-
Chen X., Garelick M. G., Wang H., Li V., Athos J., Storm D. R., PI3 kinase signaling is required for retrieval and extinction of contextual memory. Nature Neuroscience 2005 8 7 925 931 2-s2.0-24944532213 10.1191/ 0959683605hl863rr (Pubitemid 41361214)
-
(2005)
Holocene
, vol.15
, Issue.6
, pp. 925-931
-
-
Chen, J.1
Wan, G.2
Zhang, D.D.3
Chen, Z.4
Xu, J.5
Xiao, T.6
Huang, R.7
-
55
-
-
34249794256
-
Accumulation of phosphorylated α-synuclein in dopaminergic neurons of transgenic mice that express human α-synuclein
-
DOI 10.1002/jnr.21310
-
Wakamatsu M., Ishii A., Ukai Y., Sakagami J., Iwata S., Ono M., Matsumoto K., Nakamura A., Tada N., Kobayashi K., Iwatsubo T., Yoshimoto M., Accumulation of phosphorylated α -synuclein in dopaminergic neurons of transgenic mice that express human α -synuclein. Journal of Neuroscience Research 2007 85 8 1819 1825 2-s2.0-34249794256 10.1002/jnr.21310 (Pubitemid 46849629)
-
(2007)
Journal of Neuroscience Research
, vol.85
, Issue.8
, pp. 1819-1825
-
-
Wakamatsu, M.1
Ishii, A.2
Ukai, Y.3
Sakagami, J.4
Iwata, S.5
Ono, M.6
Matsumoto, K.7
Nakamura, A.8
Tada, N.9
Kobayashi, K.10
Iwatsubo, T.11
Yoshimoto, M.12
-
56
-
-
60549109895
-
Phosphorylation does not prompt, nor prevent, the formation of α -synuclein toxic species in a rat model of Parkinson's disease
-
2-s2.0-60549109895 10.1093/hmg/ddn417
-
da Silveira S. A., Schneider B. L., Cifuentes-Diaz C., Sage D., Abbas-Terki T., Iwatsubo T., Unser M., Aebischer P., Phosphorylation does not prompt, nor prevent, the formation of α -synuclein toxic species in a rat model of Parkinson's disease. Human Molecular Genetics 2009 18 5 872 887 2-s2.0-60549109895 10.1093/hmg/ddn417
-
(2009)
Human Molecular Genetics
, vol.18
, Issue.5
, pp. 872-887
-
-
Da Silveira, S.A.1
Schneider, B.L.2
Cifuentes-Diaz, C.3
Sage, D.4
Abbas-Terki, T.5
Iwatsubo, T.6
Unser, M.7
Aebischer, P.8
-
57
-
-
77449113371
-
Phosphorylation of synucleins by members of the polo-like kinase family
-
2-s2.0-77449113371 10.1074/jbc.M109.081950
-
Mbefo M. K., Paleologou K. E., Boucharaba A., Oueslati A., Schell H., Fournier M., Olschewski D., Yin G., Zweckstetter M., Masliah E., Kahle P. J., Hirling H., Lashuel H. A., Phosphorylation of synucleins by members of the polo-like kinase family. Journal of Biological Chemistry 2010 285 4 2807 2822 2-s2.0-77449113371 10.1074/jbc.M109.081950
-
(2010)
Journal of Biological Chemistry
, vol.285
, Issue.4
, pp. 2807-2822
-
-
Mbefo, M.K.1
Paleologou, K.E.2
Boucharaba, A.3
Oueslati, A.4
Schell, H.5
Fournier, M.6
Olschewski, D.7
Yin, G.8
Zweckstetter, M.9
Masliah, E.10
Kahle, P.J.11
Hirling, H.12
Lashuel, H.A.13
-
58
-
-
0034614415
-
Constitutive phosphorylation of the Parkinson's disease associated α- synuclein
-
DOI 10.1074/jbc.275.1.390
-
Okochi M., Walter J., Koyama A., Nakajo S., Baba M., Iwatsubo T., Meijer L., Kahle P. J., Haass C., Constitutive phosphorylation of the Parkinson's disease associated α -synuclein. Journal of Biological Chemistry 2000 275 1 390 397 2-s2.0-0034614415 10.1074/jbc.275.1.390 (Pubitemid 30038997)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.1
, pp. 390-397
-
-
Okochi, M.1
Walter, J.2
Koyama, A.3
Nakajo, S.4
Baba, M.5
Iwatsubo, T.6
Meijer, L.7
Kahle, P.J.8
Haass, C.9
-
59
-
-
67651008224
-
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications
-
2-s2.0-67651008224 10.1016/j.bbrc.2009.06.142
-
Qing H., Wong W., McGeer E. G., McGeer P. L., Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications. Biochemical and Biophysical Research Communications 2009 387 1 149 152 2-s2.0-67651008224 10.1016/j.bbrc.2009.06.142
-
(2009)
Biochemical and Biophysical Research Communications
, vol.387
, Issue.1
, pp. 149-152
-
-
Qing, H.1
Wong, W.2
McGeer, E.G.3
McGeer, P.L.4
-
60
-
-
84861144992
-
Suppression of alpha-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context
-
Sancenon V., Lee S. A., Patrick C., Griffith J., Paulino A., Outeiro T. F., Reggiori F., Masliah E., Muchowski P. J., Suppression of alpha-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context. Human Molecular Genetics 2012 21 2432 2449
-
(2012)
Human Molecular Genetics
, vol.21
, pp. 2432-2449
-
-
Sancenon, V.1
Lee, S.A.2
Patrick, C.3
Griffith, J.4
Paulino, A.5
Outeiro, T.F.6
Reggiori, F.7
Masliah, E.8
Muchowski, P.J.9
-
61
-
-
84867045179
-
Alpha-synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2
-
Wang S., Xu B., Liou L. C., Ren Q., Huang S., Luo Y., Zhang Z., Witt S. N., Alpha-synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2. Proceedings of the National Academy of Sciences of the United States of America 2012 109 16119 16124
-
(2012)
Proceedings of the National Academy of Sciences of the United States of America
, vol.109
, pp. 16119-16124
-
-
Wang, S.1
Xu, B.2
Liou, L.C.3
Ren, Q.4
Huang, S.5
Luo, Y.6
Zhang, Z.7
Witt, S.N.8
-
62
-
-
20544432791
-
Cell wall integrity signaling in Saccharomyces cerevisiae
-
DOI 10.1128/MMBR.69.2.262-291.2005
-
Levin D. E., Cell wall integrity signaling in Saccharomyces cerevisiae. Microbiology and Molecular Biology Reviews 2005 69 262 291 (Pubitemid 40847940)
-
(2005)
Microbiology and Molecular Biology Reviews
, vol.69
, Issue.2
, pp. 262-291
-
-
Levin, D.E.1
-
63
-
-
84876214388
-
Calcium, bioenergetics, and neuronal vulnerability in Parkinson's disease
-
Surmeier D. J., Schumacker P. T., Calcium, bioenergetics, and neuronal vulnerability in Parkinson's disease. The Journal of Biological Chemistry 2013 288 10736 10741
-
(2013)
The Journal of Biological Chemistry
, vol.288
, pp. 10736-10741
-
-
Surmeier, D.J.1
Schumacker, P.T.2
-
64
-
-
79959500244
-
Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease
-
2-s2.0-79959500244 10.1002/biof.159
-
Calì T., Ottolini D., Brini M., Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease. BioFactors 2011 37 3 228 240 2-s2.0-79959500244 10.1002/biof.159
-
(2011)
BioFactors
, vol.37
, Issue.3
, pp. 228-240
-
-
Calì, T.1
Ottolini, D.2
Brini, M.3
-
65
-
-
70350780212
-
2+ signaling in human neuroblastoma (SH-SY5Y) cells
-
2-s2.0-70350780212 10.1111/j.1471-4159.2009.06411.x
-
2+ signaling in human neuroblastoma (SH-SY5Y) cells. Journal of Neurochemistry 2009 111 5 1192 1201 2-s2.0-70350780212 10.1111/j.1471-4159. 2009.06411.x
-
(2009)
Journal of Neurochemistry
, vol.111
, Issue.5
, pp. 1192-1201
-
-
Hettiarachchi, N.T.1
Parker, A.2
Dallas, M.L.3
Pennington, K.4
Hung, C.-C.5
Pearson, H.A.6
Boyle, J.P.7
Robinson, P.8
Peers, C.9
-
66
-
-
78751701091
-
Raised calcium promotes α -synuclein aggregate formation
-
2-s2.0-78751701091 10.1016/j.mcn.2010.12.004
-
Nath S., Goodwin J., Engelborghs Y., Pountney D. L., Raised calcium promotes α -synuclein aggregate formation. Molecular and Cellular Neuroscience 2011 46 2 516 526 2-s2.0-78751701091 10.1016/j.mcn.2010.12.004
-
(2011)
Molecular and Cellular Neuroscience
, vol.46
, Issue.2
, pp. 516-526
-
-
Nath, S.1
Goodwin, J.2
Engelborghs, Y.3
Pountney, D.L.4
-
67
-
-
78751701091
-
Raised calcium promotes α -synuclein aggregate formation
-
2-s2.0-78751701091 10.1016/j.mcn.2010.12.004
-
Nath S., Goodwin J., Engelborghs Y., Pountney D. L., Raised calcium promotes α -synuclein aggregate formation. Molecular and Cellular Neuroscience 2011 46 2 516 526 2-s2.0-78751701091 10.1016/j.mcn.2010.12.004
-
(2011)
Molecular and Cellular Neuroscience
, vol.46
, Issue.2
, pp. 516-526
-
-
Nath, S.1
Goodwin, J.2
Engelborghs, Y.3
Pountney, D.L.4
-
68
-
-
84873703372
-
2+ levels to alpha-synuclein toxicity in Parkinson's disease models
-
2+ levels to alpha-synuclein toxicity in Parkinson's disease models. Cell Death & Differentiation 2012 20 465 477
-
(2012)
Cell Death & Differentiation
, vol.20
, pp. 465-477
-
-
Büttner, S.1
Faes, L.2
Reichelt, W.N.3
Broeskamp, F.4
Habernig, L.5
Benke, S.6
Kourtis, N.7
Ruli, D.8
Carmona-Gutierrez, D.9
Eisenberg, T.10
'Hooge, P.D.11
Ghillebert, R.12
Franssens, V.13
Harger, A.14
Pieber, T.R.15
Freudenberger, P.16
Kroemer, G.17
Sigrist, S.J.18
Winderickx, J.19
Callewaert, G.20
Tavernarakis, N.21
Madeo, F.22
more..
-
69
-
-
84863938643
-
In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy
-
Reznichenko L., Cheng Q., Nizar K., Gratiy S. L., Saisan P. A., Rockenstein E. M., Gonzalez T., Patrick C., Spencer B., Desplats P., Dale A. M., Devor A., Masliah E., In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy. The Journal of Neuroscience 2012 32 9992 9998
-
(2012)
The Journal of Neuroscience
, vol.32
, pp. 9992-9998
-
-
Reznichenko, L.1
Cheng, Q.2
Nizar, K.3
Gratiy, S.L.4
Saisan, P.A.5
Rockenstein, E.M.6
Gonzalez, T.7
Patrick, C.8
Spencer, B.9
Desplats, P.10
Dale, A.M.11
Devor, A.12
Masliah, E.13
-
70
-
-
34347359673
-
'Rejuvenation' protects neurons in mouse models of Parkinson's disease
-
DOI 10.1038/nature05865, PII NATURE05865
-
Chan C. S., Guzman J. N., Ilijic E., Mercer J. N., Rick C., Tkatch T., Meredith G. E., Surmeier D. J., 'Rejuvenation' protects neurons in mouse models of Parkinson's disease. Nature 2007 447 7148 1081 1086 2-s2.0-34347359673 10.1038/nature05865 (Pubitemid 47014425)
-
(2007)
Nature
, vol.447
, Issue.7148
, pp. 1081-1086
-
-
Chan, C.S.1
Guzman, J.N.2
Ilijic, E.3
Mercer, J.N.4
Rick, C.5
Tkatch, T.6
Meredith, G.E.7
Surmeier, D.J.8
-
71
-
-
78649866553
-
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1
-
2-s2.0-78649866553 10.1038/nature09536
-
Guzman J. N., Sanchez-Padilla J., Wokosin D., Kondapalli J., Ilijic E., Schumacker P. T., Surmeier D. J., Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature 2010 468 7324 696 700 2-s2.0-78649866553 10.1038/nature09536
-
(2010)
Nature
, vol.468
, Issue.7324
, pp. 696-700
-
-
Guzman, J.N.1
Sanchez-Padilla, J.2
Wokosin, D.3
Kondapalli, J.4
Ilijic, E.5
Schumacker, P.T.6
Surmeier, D.J.7
-
72
-
-
0034578389
-
Aggresomes, inclusion bodies and protein aggregation
-
2-s2.0-0034578389 10.1016/S0962-8924(00)01852-3
-
Kopito R. R., Aggresomes, inclusion bodies and protein aggregation. Trends in Cell Biology 2000 10 12 524 530 2-s2.0-0034578389 10.1016/S0962- 8924(00)01852-3
-
(2000)
Trends in Cell Biology
, vol.10
, Issue.12
, pp. 524-530
-
-
Kopito, R.R.1
-
73
-
-
74549184412
-
The polarisome is required for segregation and retrograde transport of protein aggregates
-
2-s2.0-74549184412 10.1016/j.cell.2009.12.031
-
Liu B., Larsson L., Caballero A., Hao X., Öling D., Grantham J., Nyström T., The polarisome is required for segregation and retrograde transport of protein aggregates. Cell 2010 140 2 257 267 2-s2.0-74549184412 10.1016/j.cell.2009.12.031
-
(2010)
Cell
, vol.140
, Issue.2
, pp. 257-267
-
-
Liu, B.1
Larsson, L.2
Caballero, A.3
Hao, X.4
Öling, D.5
Grantham, J.6
Nyström, T.7
-
74
-
-
81855218130
-
Segregation of protein aggregates involves actin and the polarity machinery
-
2-s2.0-81855218130 10.1016/j.cell.2011.11.018
-
Liu B., Larsson L., Franssens V., Hao X., Hill S. M., Andersson V., Höglund D., Song J., Yang X., Öling D., Grantham J., Winderickx J., Nyström T., Segregation of protein aggregates involves actin and the polarity machinery. Cell 2011 147 5 959 961 2-s2.0-81855218130 10.1016/j.cell.2011.11.018
-
(2011)
Cell
, vol.147
, Issue.5
, pp. 959-961
-
-
Liu, B.1
Larsson, L.2
Franssens, V.3
Hao, X.4
Hill, S.M.5
Andersson, V.6
Höglund, D.7
Song, J.8
Yang, X.9
Öling, D.10
Grantham, J.11
Winderickx, J.12
Nyström, T.13
-
75
-
-
80053372157
-
Aggresome formation and segregation of inclusions influence toxicity of α -synuclein and synphilin-1 in yeast
-
2-s2.0-80053372157 10.1042/BST0391476
-
Swinnen E., Büttner S., Outeiro T. F., Galas M.-C., Madeo F., Winderickx J., Franssens V., Aggresome formation and segregation of inclusions influence toxicity of α -synuclein and synphilin-1 in yeast. Biochemical Society Transactions 2011 39 5 1476 1481 2-s2.0-80053372157 10.1042/BST0391476
-
(2011)
Biochemical Society Transactions
, vol.39
, Issue.5
, pp. 1476-1481
-
-
Swinnen, E.1
Büttner, S.2
Outeiro, T.F.3
Galas, M.-C.4
Madeo, F.5
Winderickx, J.6
Franssens, V.7
|