The chinese herb isolate yuanhuacine (YHL-14) induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade

Journal of Biological Chemistry

Volumn 289, Issue 10, 2014, Pages 6394-6403

  Zhang, Ruowen ^a,b   Wang, Yulei ^a   Li, Jingxia ^a   Jin, Honglei ^a   Song, Shaojiang ^b   Huang, Chuanshu ^b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS;

ANTICANCER EFFECTS; CANCER CELL GROWTH; COLON CANCER CELLS; G2/M PHASE ARRESTS; HUMAN CANCER CELLS; POTENTIAL MECHANISM; PROTEIN EXPRESSIONS; PROTEIN STABILITY;

PROTEINS;

DITERPENOID; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P21; PROTEIN P53; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; YUANHUACINE;

ANCHORAGE INDEPENDENT GROWTH; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLADDER CANCER; CANCER CELL; CANCER INHIBITION; CELL GROWTH; CELL PROLIFERATION; CHINESE HERB; COLON CANCER; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; G2 PHASE CELL CYCLE CHECKPOINT; GENE INACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; TRANSACTIVATION; TRANSCRIPTION REGULATION; UPREGULATION;

ANTICANCER DRUG; CELL GROWTH; MAPK; P21; P38; PROTEIN STABILITY; SP1; YUANHUACINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DAPHNE; DITERPENES; DRUGS, CHINESE HERBAL; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION; URINARY BLADDER NEOPLASMS;

EID: 84896765907     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.513960     Document Type: Article

References (49)

1. Sisodiya, D., Dashora, K., and Pandey, P. (2012) Cellular organization and cell reproduction. IJAPBC 1, 138-150
2. De Souza, C. P., and Osmani, S. A. (2007) Mitosis, not just open or closed. Eukaryot. Cell 6, 1521-1527
3. Maton, A., Hopkins, Jean Johnson, Susan LaHart, David, Quon Warner, David, Wright, Jill D (1997) Cells. Building Blocks of Life, pp. 76-80, Pearson Prentice Hall, Upper Saddle River, NJ
4. Evan, G. I., and Vousden, K. H. (2001) Proliferation, cell cycle and apoptosis in cancer. Nature 411, 342-348
5. Vinay, K. M., Abulk, A. M., and Nelson, F. (2004) Robbins and Cotran Pathologic Basis of Disease, pp. 331-340, Elsevier's Health Sciences, Philadelphia, PA
6. Zhou, J. J., Xie, G., and Yan, X. (2013) Encyclopedia of traditional Chinese Medicines, Vol. 5, pp. 227-229, Springer, Berlin
7. Hall, I. H., Liou, Y. F., Oswald, C. B., and Lee, K. H. (1986) The effects of genkwadaphnin and gnidilatidin on the growth of P-388, L-1210 leukemia and KB carcinoma cells in vitro. Eur. J. Cancer Clin. Oncol. 22, 45-52
8. Zhan, Z. J., Fan, C. Q., Ding, J., and Yue, J. M. (2005) Novel diterpenoids with potent inhibitory activity against endothelium cell HMEC and cytotoxic activities from a well known TCM plant Daphne genkwa. Bioorg. Med. Chem. 13, 645-655
9. Bhandurge, P., Rajarajeshwari, N., Ganapaty, S., and Pattanshetti, S. (2013) The Gnidia genus:Areview. Asian Journal of Biomedical and Pharmaceutical Sciences 3, 1-31
10. Zhang, S., Li, X., Zhang, F., Yang, P., Gao, X., and Song, Q. (2006) Preparation of yuanhuacine and relative Daphne diterpene esters from Daphne genkwa and structure-activity relationship of potent inhibitory activity against DNA topoisomerase I. Bioorg. Med. Chem. 14, 3888-3895
11. Jemal, A., Bray, F., Center, M. M., Ferlay, J., Ward, E., and Forman, D. (2011) Global cancer statistics. CA-Cancer J. Clin. 61, 69-90
12. WHOLibrary Cataloguing-in-Publication Data (2010) World Health Statistics. World Health Organization, pp. 18-23, Geneva
13. WHO Library Cataloguing-in-Publication Data (2009) Global health risks: mortality and burden of disease attributable to selected major risks. World Health Organization, pp. 1-25, Geneva
14. Harding, M. A., and Theodorescu, D. (2010) RhoGDI signaling provides targets for cancer therapy. Eur. J. Cancer 46, 1252-1259
15. Cummins, J. M., Kohli, M., Rago, C., Kinzler, K. W., Vogelstein, B., and Bunz, F. (2004) X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells. Cancer Res. 64, 3006-3008
16. Robbins, D. J., Zhen, E., Owaki, H., Vanderbilt, C. A., Ebert, D., Geppert, T. D., and Cobb, M. H. (1993) Regulation and properties of extracellular signalregulated protein kinases 1 and 2 in vitro. J. Biol. Chem. 268, 5097-5106
17. Huang, C., Ma, W. Y., and Dong, Z. (1999) The extracellular-signal- regulated protein kinases (Erks) are required for UV-induced AP-1 activation in JB6 cells. Oncogene 18, 2828-2835
18. Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J., and Davis, R. J. (1995) Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270, 7420-7426
19. Zhang, D., Song, L., Li, J., Wu, K., and Huang, C. (2006) Coordination of JNK1 and JNK2 is critical for GADD45 induction and its mediated cell apoptosis in arsenite responses. J. Biol. Chem. 281, 34113-34123
20. Huang, C., Ma, W. Y., Maxiner, A., Sun, Y., and Dong, Z. (1999) p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389. J. Biol. Chem. 274, 12229-12235
21. Westfall, M. D., D. J. M., Joseph C. Sniezek, and Jennifer A. Pietenpol (2003) The Np63 phosphoprotein Binds the p21 and 14-3-3 promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. Mol. Cell. Biol. 23, 2264-2276
22. Zhang, D., Li, J., Costa, M., Gao, J., and Huang, C. (2010) JNK1 mediates degradation HIF-1 by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70. Cancer Res. 70, 813-823
23. Ding, J., Li, J., Xue, C., Wu, K., Ouyang, W., Zhang, D., Yan, Y., and Huang C. (2006) Cyclooxygenase-2 induction by arsenite is through a nuclear factor of activated T-cell-dependent pathway and plays an antiapoptotic role in Beas-2B cells. J. Biol. Chem. 281, 24405-24413
24. Cai, T., Li, X., Ding, J., Luo, W., Li, J., and Huang, C. (2011) A cross-talk between NFAT and NFB pathways is crucial for nickel-induced COX-2 expression in Beas-2B cells. Curr. Cancer Drug Targets 11, 548-559
25. Liu, J., Zhang, D., Mi, X., Xia, Q., Yu, Y., Zuo, Z., Guo, W., Zhao, X., Cao, J., Yang, Q., Zhu, A., Yang, W., Shi, X., Li, J., and Huang, C. (2010) p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun-and HSF-1-dependent pathways. J. Biol. Chem. 285, 26058-26065
26. Luo, W., Liu, J., Li, J., Zhang, D., Liu, M., Addo, J. K., Patil, S., Zhang, L., Yu, J., Buolamwini, J. K., Chen, J., and Huang, C. (2008) Anti-cancer effects of JKA97 are associated with its induction of cell apoptosis via a Bax-dependent and p53-independent pathway. J. Biol. Chem. 283, 8624-8633
27. el-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., and Vogelstein, B. (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817-825
28. Hong, J. Y., Chung, H. J., Lee, H. J., Park, H. J., and Lee, S. K. (2011) Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa. J. Nat. Prod. 74, 2102-2108
29. Hong, J. Y., Nam, J. W., Seo, E. K., and Lee, S. K. (2010) Daphnane diterpene esters with anti-proliferative activities against human lung cancer cells from Daphne genkwa. Chem. Pharm. Bull. 58, 234-237
30. Park, B. Y., Min, B. S., Ahn, K. S., Kwon, O. K., Joung, H., Bae, K. H., Lee, H. K., and Oh, S. R. (2007) Daphnane diterpene esters isolated from flower buds of Daphne genkwa induce apoptosis in human myelocytic HL-60 cells and suppress tumor growth in Lewis lung carcinoma (LLC)-inoculated mouse model. J. Ethnopharmacol. 111, 496-503
31. Zhang, S. (2009) Evaluation of poly(D,L-lactide-co-glycolide) microspheres for the lung-targeting of yuanhuacine, a novel DNA topoisomerase I inhibitor. J. Drug Target. 17, 286-293
32. Lakin, N. D., and Jackson, S. P. (1999) Regulation of p53 in response to DNA damage. Oncogene 18, 7644-7655
33. Gartner, A. (2000)Aconserved checkpoint pathway mediatesDNAdamageinduced apoptosis and cell cycle arrest in C. elegans. Mol. Cell 5, 435-443
34. Macleod, K. F. (1995) p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev. 9, 935-944
35. Harper, J. W. (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816
36. Gartel, A. L. (2000) Sp1 and Sp3 activate p21 (WAF1/CIP1) gene transcription in the Caco-2 colon adenocarcinoma cell line. Oncogene 19, 5182-5188
37. Gartel, A. L., and Radhakrishnan, S. K. (2005) Lost in transcription. p21 repression, mechanisms, and consequences. Cancer Res. 65, 3980-3985
38. Chuang, J. Y. (2008) Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosis. Mol. Biol. Cell 19, 1139-1151
39. D'Addario, M., Arora, P. D., and McCulloch, C. A. (2006) Role of p38 in stress activation of Sp1. Gene 379, 51-61
40. Tan, N. Y., and Khachigian, L. M. (2009) Sp1 phosphorylation and its regulation of gene transcription. Mol. Cell. Biol. 29, 2483-2488
41. Chintharlapalli, S., Papineni, S., Ramaiah, S. K., and Safe, S. (2007) Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors. Cancer Res. 67, 2816-2823
42. Chadalapaka, G., Jutooru, I., and Safe, S. (2012) Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells. Carcinogenesis 33, 886-894
43. Jutooru, I., Chadalapaka, G., Lei, P., and Safe, S. (2010) Inhibition of NFκB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation. J. Biol. Chem. 285, 25332-25344
44. Zarubin, T., and Han, J. (2005) Activation and signaling of the p38 MAP kinase pathway. Cell Res. 15, 11-18
45. Mikhailov, A., Shinohara, M., and Rieder, C. L. (2005) The p38-mediated stress-activated checkpoint. A rapid response system for delaying progression through antephase and entry into mitosis. Cell Cycle 4, 57-62
46. Mikhailov, A. (2007) The G2 p38-mediated stress-activated checkpoint pathway becomes attenuated in transformed cells. Curr. Biol. 17, 2162-2168
47. Eom, H. J., and Choi, J. (2010) p38 MAPK activation, DNA damage, cell cycle arrest and apoptosis as mechanisms of toxicity of silver nanoparticles in Jurkat T cells. Environ. Sci. Technol. 44, 8337-8342
48. Bulavin, D. V. (2001) Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature 411, 102-107
49. Wood, C. D. (2009) Nuclear localization of p38 MAPK in response to DNA damage. Int. J. Biol. Sci. 5, 428-437