Inhibition of NFκB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation

Journal of Biological Chemistry

Volumn 285, Issue 33, 2010, Pages 25332-25344

  Jutooru, Indira ^a   Chadalapaka, Gayathri ^a   Lei, Ping ^b   Safe, Stephen ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANGIOGENIC; ANTICANCER ACTIVITIES; APOPTOSIS; CANCER CELLS; CURCUMIN; CYCLIND1; DOWN-REGULATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NUDE MICE; PANCREATIC CANCERS; REACTIVE OXYGEN SPECIES; REGULATED GENES; RNA INTERFERENCE; SURVIVIN; TRANSACTIVATION; TUMOR GROWTH; TUMOR NECROSIS FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR;

CELL DEATH; CELL MEMBRANES; GENES; OXYGEN; RNA; TRANSCRIPTION FACTORS; TUMORS;

TRANSCRIPTION;

CURCUMIN; CYCLIN D1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; PROTEIN P50; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; SURVIVIN; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR SP; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; TRANSCRIPTION FACTOR SP4; TUMOR NECROSIS FACTOR; VASCULOTROPIN; HYDROGEN PEROXIDE; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GROWTH INHIBITION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PANCREAS CANCER; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; TRANSACTIVATION; ANIMAL; CELL PROLIFERATION; DRUG EFFECT; DRUG SCREENING; ELECTROPHYSIOLOGY; FEMALE; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; NUDE MOUSE; PANCREAS TUMOR; POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

MUS MUSCULUS;

ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CURCUMIN; CYCLIN D1; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ELECTROPHYSIOLOGY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDROGEN PEROXIDE; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, NUDE; NF-KAPPA B; PANCREATIC NEOPLASMS; POLYMERASE CHAIN REACTION; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SP TRANSCRIPTION FACTORS; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; SP4 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77955506109     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.095240     Document Type: Article

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