Preparation of yuanhuacine and relative daphne diterpene esters from Daphne genkwa and structure-activity relationship of potent inhibitory activity against DNA topoisomerase I

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 11, 2006, Pages 3888-3895

  Zhang, Shixuan ^a   Li, Xiaona ^a   Zhang, Fenghong ^a   Yang, Puwen ^a   Gao, Xiujuan ^a   Song, Qiling ^a  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Daphne diterpene esters; Daphne genkwa; Inhibitory activity against DNA topoisomerase I; Yuanhuacine

Indexed keywords

AGAROSE; CAMPTOTHECIN DERIVATIVE; DAPHNE EXTRACT; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; TERPENE DERIVATIVE; UNCLASSIFIED DRUG; YUANHUACINE; YUANHUADINE; YUANHUAGINE; YUANHUAJINE; YUANHUAPINE;

AGAR GEL ELECTROPHORESIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DAPHNE; DAPHNE GENKWA; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TRADITIONAL MEDICINE; ULTRAVIOLET RADIATION;

DAPHNE; DITERPENES; DNA TOPOISOMERASES, TYPE I; ENZYME ACTIVATION; ENZYME INHIBITORS; ESTERS; MEDICINE, ORIENTAL TRADITIONAL; MOLECULAR CONFORMATION; PLANT ROOTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TERPENES;

DAPHNE;

EID: 33646064109     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.055     Document Type: Article

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