Anti-cancer effects of JKA97 are associated with its induction of cell apoptosis via a Bax-dependent and p53-independent pathway

Journal of Biological Chemistry

Volumn 283, Issue 13, 2008, Pages 8624-8633

  Luo, Wenjing ^a,b   Liu, Jinyi ^a   Li, Jingxia ^a   Zhang, Dongyun ^a   Liu, Mingchao ^b   Addo, James K ^c   Patil, Shivaputra ^c   Zhang, Lin ^d   Yu, Jian ^d   Buolamwini, John K ^c   Chen, Jingyuan ^b   Huang, Chuanshu ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^d UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; CELL DEATH; CELL GROWTH; MITOCHONDRIA;

ANTICANCER ACTIVITIES; APOPTOSIS; APOPTOTIC RESPONSES; CANCER DEVELOPMENTS; CELL APOPTOSIS; CELL CULTURE MODELS; CELL LINES; CHALLENGING TASKS; COLON CANCERS; CYTOCHROME C; CYTOSOL; HEPATOCARCINOMA; HUMAN CANCERS; HUMAN COLON CANCERS; IN VITRO; INDUCED APOPTOSIS; INHIBITORY EFFECTS; KNOCK OUTS; METHOXY; MOLECULAR BASES; MUTATED GENES; NUDE MOUSE; SMALL MOLECULES; SYNTHETIC COMPOUNDS; THERAPEUTIC APPLICATIONS; TUMORIGENESIS; TUMORIGENICITY;

CELL CULTURE;

[METHOXY 1 STYRYL 9H PYRID (3,4 BETA) INDOLE]; ANTINEOPLASTIC AGENT; CYTOCHROME C; JKA 97; PROTEIN BAX; PROTEIN P53; UNCLASSIFIED DRUG; 1 STYRYL 9H PYRIDO(3,4 B)INDOLE; 1-STYRYL-9H-PYRIDO(3,4-B)INDOLE; APOPTOSIS REGULATORY PROTEIN; BBC3 PROTEIN, HUMAN; CARBOLINE DERIVATIVE; ONCOPROTEIN; STYRENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CARCINOGENESIS; CARCINOGENICITY; CARCINOMA CELL; CELL ANCHORAGE; CELL CULTURE; COLON CANCER; COMPETITIVE INHIBITION; CONTROLLED STUDY; CYTOSOL; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; MITOCHONDRION; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN SECRETION; ANIMAL; BODY WEIGHT; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; GENETICS; METABOLISM; NEOPLASM; PATHOLOGY; PROTEIN TRANSPORT; TUMOR CELL LINE;

MUS MUSCULUS;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; BODY WEIGHT; CARBOLINES; CELL LINE, TUMOR; FEMALE; HUMANS; MICE; MICE, NUDE; MOLECULAR STRUCTURE; NEOPLASMS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS; STYRENES; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 43749112192     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707860200     Document Type: Article

References (43)

1. Svec, J. (2005) Bratisl. Lek. Listy 106, 238-239
2. Lane, D. P. (1993) Nature 362, 786-787
3. Wang, J., Ouyang, W., Li, J., Wei, L., Ma, Q., Zhang, Z., Tong, Q., He, J., and Huang, C. (2005) Cancer Res. 65, 6601-6611
4. Tweddle, D. A., Pearson, A. D., Haber, M., Norris, M. D., Xue, C., Flemming, C., and Lunec, J. (2003) Cancer Lett. 197, 93-98
5. Cheng, J., and Haas, M. (1990) Mol. Cell. Biol. 10, 5502-5509
6. Lowe, S. W., Bodis, S., McClatchey, A., Remington, L., Ruley, H. E., Fisher, D. E., Housman, D. E., and Jacks, T. (1994) Science 266, 807-810
7. Jemal, A., Murray, T., Ward, E., Samuels, A., Tiwari, R. C., Ghafoor, A., Feuer, E. J., and Thun, M. J. (2005) CA-Cancer J. Clin. 55, 10-30
8. Tachibana, M., Kawamata, H., Fujimori, T., Omotehara, F., Horiuchi, H., Ohkura, Y., Igarashi, S., Kotake, K., and Kubota, K. (2004) Int. J. Oncol. 25, 913-920
9. Debatin, K. (2000) Toxicol. Lett. 112-113, 41-48
10. Kaufmann, S. H., and Earnshaw, W. C. (2000) Exp. Cell Res. 256, 42-49
11. Zhang, L., Yu, J., Park, B. H., Kinzler, K. W., and Vogelstein, B. (2000) Science 290, 989-992
12. Huang, C., Ma, W., Ding, M., Bowden, G. T., and Dong, Z. (1997) J. Biol. Chem. 272, 27753-27757
13. Li, J., Song, L., Zhang, D., Wei, L., and Huang, C. (2006) J. Cell. Biochem. 99, 1010-1020
14. Ouyang, W., Ma, Q., Li, J., Zhang, D., Liu, Z. G., Rustgi, A. K., and Huang, C. (2005) Cancer Res. 65, 9287-9293
15. Peyruchaud, O., Serre, C. M., NicAmhlaoibh, R., Fournier, P., and Clezardin, P. (2003) J. Biol. Chem. 278, 45826-45832
16. Mullen, S. F., and Critser, J. K. (2004) Methods Mol. Biol. 254, 393-406
17. Jalota, A., Singh, K., Pavithra, L., Kaul-Ghanekar, R., Jameel, S., and Chattopadhyay, S. (2005) J. Biol. Chem. 280, 16019-16029
18. Yu, J., and Zhang, L. (2003) Cancer Cell 4, 248-249
19. Antonsson, B., Montessuit, S., Lauper, S., Eskes, R., and Martinou, J. C. (2000) Biochem. J. 345, 271-278
20. Cho, H. J., Kim, J. K., Kim, K. D., Yoon, H. K., Cho, M. Y., Park, Y. P., Jeon, J. H., Lee, E. S., Byun, S. S., Lim, H. M., Song, E. Y., Lim, J. S., Yoon, D. Y., Lee, H. G., and Choe, Y. K. (2006) Cancer Lett. 237, 56-66
21. Evan, G. I., and Vousden, K. H. (2001) Nature 411, 342-348
22. Cragg, G. M., Newman, D. J., and Snader, K. M. (1997) J. Nat. Prod. (Lloydia) 60, 52-60
23. Nagle, D. G., Zhou, Y. D., Mora, F. D., Mohammed, K. A., and Kim, Y. P. (2004) Curr. Med. Chem. 11, 1725-1756
24. Marsoni, S., and Damia, G. (2004) Ann Oncol 15, Suppl. 4, iv229-iv231
25. Fridman, J. S., and Lowe, S. W. (2003) Oncogene 22, 9030-9040
26. Cohen, G. M. (1997) Biochem. J. 326, 1-16
27. Reed, J. C. (1997) Cell 91, 559-562
28. Strasser, A., O'Connor, L., and Dixit, V. M. (2000) Annu. Rev. Biochem. 69, 217-245
29. Hajra, K. M., and Liu, J. R. (2004) Apoptosis 9, 691-704
30. Green, D. R. (2000) Cell 102, 1-4
31. Kroemer, G., and Reed, J. C. (2000) Nat. Med. 6, 513-519
32. Lin, C. H., Lu, Y. Z., Cheng, F. C., Chu, L. F., and Hsueh, C. M. (2005) Neurosci. Lett. 387, 22-27
33. Narita, M., Shimizu, S., Ito, T., Chittenden, T., Lutz, R. J., Matsuda, H., and Tsujimoto, Y. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 14681-14686
34. Antonsson, B., Montessuit, S., Sanchez, B., and Martinou, J. C. (2001) J. Biol. Chem. 276, 11615-11623
35. Eskes, R., Desagher, S., Antonsson, B., and Martinou, J. C. (2000) Mol. Cell. Biol. 20, 929-935
36. Kuwana, T., Mackey, M. R., Perkins, G., Ellisman, M. H., Latterich, M., Schneiter, R., Green, D. R., and Newmeyer, D. D. (2002) Cell 111, 331-342
37. Kim, B. J., Ryu, S. W., and Song, B. J. (2006) J. Biol. Chem. 281, 21256-21265
38. Tikhomirov, O., and Carpenter, G. (2005) J. Cell Sci. 118, 5681-5690
39. Sarkar, F. H., Rahman, K. M., and Li, Y. (2003) J. Nutr. 133, Suppl. 7, 2434S-2439S
40. Gogvadze, V., Robertson, J. D., Zhivotovsky, B., and Orrenius, S. (2001) J. Biol. Chem. 276, 19066-19071
41. Li, P. F., Dietz, R., and von Harsdorf, R. (1999) EMBO J. 18, 6027-6036
42. Eskes, R., Antonsson, B., Osen-Sand, A., Montessuit, S., Richter, C., Sadoul, R., Mazzei, G., Nichols, A., and Martinou, J. C. (1998) J. Cell Biol. 143, 217-224
43. Song, Y, Kesuma, D., Wang, J., Deng, Y., Duan, J., Wang, J. H., and Qi, R. Z. (2004) Biochem. Biophys. Res. Commun. 317, 128-132