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Volumn 46, Issue 7, 2010, Pages 1252-1259

RhoGDI signaling provides targets for cancer therapy

Author keywords

Angiogenesis; Bladder cancer; Breast cancer; Cancer therapy; Guanine Nucleotide Dissociation Inhibitors; Pancreatic cancer; RhoGDI1; RhoGDI2; RhoGDIs; RhoGTPase

Indexed keywords

ATRASENTAN; CISPLATIN; ENDOTHELIN 1; GEMCITABINE; GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR; GUANOSINE TRIPHOSPHATASE; N (3 METHOXY 5 METHYL 2 PYRAZINYL) 2 [4 (1,3,4 OXADIAZOL 2 YL)PHENYL] 3 PYRIDINESULFONAMIDE; NEUROMEDIN U; RHO FACTOR;

EID: 77950595288     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2010.02.025     Document Type: Article
Times cited : (77)

References (61)
  • 1
    • 65649146486 scopus 로고    scopus 로고
    • Signaling through Rho GTPase pathway as viable drug target
    • Lu Q., Longo F.M., Zhou H., Massa S.M., and Chen Y.H. Signaling through Rho GTPase pathway as viable drug target. Curr Med Chem 16 11 (2009) 1355-1365
    • (2009) Curr Med Chem , vol.16 , Issue.11 , pp. 1355-1365
    • Lu, Q.1    Longo, F.M.2    Zhou, H.3    Massa, S.M.4    Chen, Y.H.5
  • 2
    • 0037469079 scopus 로고    scopus 로고
    • Ras superfamily monomeric G proteins in carcinoma cell motility
    • Oxford G., and Theodorescu D. Ras superfamily monomeric G proteins in carcinoma cell motility. Cancer Lett 189 2 (2003) 117-128
    • (2003) Cancer Lett , vol.189 , Issue.2 , pp. 117-128
    • Oxford, G.1    Theodorescu, D.2
  • 3
    • 21744432683 scopus 로고    scopus 로고
    • GDIs: central regulatory molecules in Rho GTPase activation
    • DerMardirossian C., and Bokoch G.M. GDIs: central regulatory molecules in Rho GTPase activation. Trends Cell Biol 15 7 (2005) 356-363
    • (2005) Trends Cell Biol , vol.15 , Issue.7 , pp. 356-363
    • DerMardirossian, C.1    Bokoch, G.M.2
  • 4
    • 23944518413 scopus 로고    scopus 로고
    • RhoGDI: multiple functions in the regulation of Rho family GTPase activities
    • Dovas A., and Couchman J.R. RhoGDI: multiple functions in the regulation of Rho family GTPase activities. Biochem J 390 Pt 1 (2005) 1-9
    • (2005) Biochem J , vol.390 , Issue.PART 1 , pp. 1-9
    • Dovas, A.1    Couchman, J.R.2
  • 5
    • 26944440432 scopus 로고    scopus 로고
    • RhoGDIs revisited: novel roles in Rho regulation
    • Dransart E., Olofsson B., and Cherfils J. RhoGDIs revisited: novel roles in Rho regulation. Traffic 6 11 (2005) 957-966
    • (2005) Traffic , vol.6 , Issue.11 , pp. 957-966
    • Dransart, E.1    Olofsson, B.2    Cherfils, J.3
  • 6
    • 23844483864 scopus 로고    scopus 로고
    • RhoGDI-3, a promising system to investigate the regulatory function of rhoGDIs: uncoupling of inhibitory and shuttling functions of rhoGDIs
    • Dransart E., Morin A., Cherfils J., and Olofsson B. RhoGDI-3, a promising system to investigate the regulatory function of rhoGDIs: uncoupling of inhibitory and shuttling functions of rhoGDIs. Biochem Soc Trans 33 Pt 4 (2005) 623-626
    • (2005) Biochem Soc Trans , vol.33 , Issue.PART 4 , pp. 623-626
    • Dransart, E.1    Morin, A.2    Cherfils, J.3    Olofsson, B.4
  • 8
    • 44449178868 scopus 로고    scopus 로고
    • Rho GTPases in cancer cell biology
    • Vega F.M., and Ridley A.J. Rho GTPases in cancer cell biology. FEBS Lett 582 14 (2008) 2093-2101
    • (2008) FEBS Lett , vol.582 , Issue.14 , pp. 2093-2101
    • Vega, F.M.1    Ridley, A.J.2
  • 9
    • 69949132404 scopus 로고    scopus 로고
    • New insights into how the Rho guanine nucleotide dissociation inhibitor regulates the interaction of Cdc42 with membranes
    • Johnson J.L., Erickson J.W., and Cerione R.A. New insights into how the Rho guanine nucleotide dissociation inhibitor regulates the interaction of Cdc42 with membranes. J Biol Chem 284 35 (2009) 23860-23871
    • (2009) J Biol Chem , vol.284 , Issue.35 , pp. 23860-23871
    • Johnson, J.L.1    Erickson, J.W.2    Cerione, R.A.3
  • 10
    • 0042761752 scopus 로고    scopus 로고
    • RhoGDI is required for Cdc42-mediated cellular transformation
    • Lin Q., Fuji R.N., Yang W., and Cerione R.A. RhoGDI is required for Cdc42-mediated cellular transformation. Curr Biol 13 17 (2003) 1469-1479
    • (2003) Curr Biol , vol.13 , Issue.17 , pp. 1469-1479
    • Lin, Q.1    Fuji, R.N.2    Yang, W.3    Cerione, R.A.4
  • 11
    • 0032579315 scopus 로고    scopus 로고
    • Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity
    • Gorvel J.P., Chang T.C., Boretto J., Azuma T., and Chavrier P. Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity. FEBS Lett 422 2 (1998) 269-273
    • (1998) FEBS Lett , vol.422 , Issue.2 , pp. 269-273
    • Gorvel, J.P.1    Chang, T.C.2    Boretto, J.3    Azuma, T.4    Chavrier, P.5
  • 12
    • 0027526303 scopus 로고
    • CDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins
    • Lelias J.M., Adra C.N., Wulf G.M., Guillemot J.C., Khagad M., Caput D., et al. CDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins. Proc Natl Acad Sci USA 90 4 (1993) 1479-1483
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.4 , pp. 1479-1483
    • Lelias, J.M.1    Adra, C.N.2    Wulf, G.M.3    Guillemot, J.C.4    Khagad, M.5    Caput, D.6
  • 13
    • 67650478384 scopus 로고    scopus 로고
    • Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway
    • Elfenbein A., Rhodes J.M., Meller J., Schwartz M.A., Matsuda M., and Simons M. Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway. J Cell Biol 186 1 (2009) 75-83
    • (2009) J Cell Biol , vol.186 , Issue.1 , pp. 75-83
    • Elfenbein, A.1    Rhodes, J.M.2    Meller, J.3    Schwartz, M.A.4    Matsuda, M.5    Simons, M.6
  • 14
    • 34548791299 scopus 로고    scopus 로고
    • GDI-1 phosphorylation switch at serine 96 induces RhoA activation and increased endothelial permeability
    • Knezevic N., Roy A., Timblin B., Konstantoulaki M., Sharma T., Malik A.B., et al. GDI-1 phosphorylation switch at serine 96 induces RhoA activation and increased endothelial permeability. Mol Cell Biol 27 18 (2007) 6323-6333
    • (2007) Mol Cell Biol , vol.27 , Issue.18 , pp. 6323-6333
    • Knezevic, N.1    Roy, A.2    Timblin, B.3    Konstantoulaki, M.4    Sharma, T.5    Malik, A.B.6
  • 15
    • 0035933870 scopus 로고    scopus 로고
    • Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function
    • Mehta D., Rahman A., and Malik A.B. Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function. J Biol Chem 276 25 (2001) 22614-22620
    • (2001) J Biol Chem , vol.276 , Issue.25 , pp. 22614-22620
    • Mehta, D.1    Rahman, A.2    Malik, A.B.3
  • 16
    • 3042839349 scopus 로고    scopus 로고
    • Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase
    • DerMardirossian C., Schnelzer A., and Bokoch G.M. Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase. Mol Cell 15 1 (2004) 117-127
    • (2004) Mol Cell , vol.15 , Issue.1 , pp. 117-127
    • DerMardirossian, C.1    Schnelzer, A.2    Bokoch, G.M.3
  • 17
    • 0033598349 scopus 로고    scopus 로고
    • Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIalpha
    • Togawa A., Miyoshi J., Ishizaki H., Tanaka M., Takakura A., Nishioka H., et al. Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIalpha. Oncogene 18 39 (1999) 5373-5380
    • (1999) Oncogene , vol.18 , Issue.39 , pp. 5373-5380
    • Togawa, A.1    Miyoshi, J.2    Ishizaki, H.3    Tanaka, M.4    Takakura, A.5    Nishioka, H.6
  • 18
    • 10144252434 scopus 로고    scopus 로고
    • Targeted disruption of guanosine diphosphate-dissociation inhibitor for Rho-related proteins, GDID4: normal hematopoietic differentiation but subtle defect in superoxide production by macrophages derived from in vitro embryonal stem cell differentiation
    • Guillemot J.C., Kruskal B.A., Adra C.N., Zhu S., Ko J.L., Burch P., et al. Targeted disruption of guanosine diphosphate-dissociation inhibitor for Rho-related proteins, GDID4: normal hematopoietic differentiation but subtle defect in superoxide production by macrophages derived from in vitro embryonal stem cell differentiation. Blood 88 7 (1996) 2722-2731
    • (1996) Blood , vol.88 , Issue.7 , pp. 2722-2731
    • Guillemot, J.C.1    Kruskal, B.A.2    Adra, C.N.3    Zhu, S.4    Ko, J.L.5    Burch, P.6
  • 19
    • 0030869004 scopus 로고    scopus 로고
    • Immune responses in mice deficient in Ly-GDI, a lymphoid-specific regulator of Rho GTPases
    • Yin L., Schwartzberg P., Scharton-Kersten T.M., Staudt L., and Lenardo M. Immune responses in mice deficient in Ly-GDI, a lymphoid-specific regulator of Rho GTPases. Mol Immunol 34 6 (1997) 481-491
    • (1997) Mol Immunol , vol.34 , Issue.6 , pp. 481-491
    • Yin, L.1    Schwartzberg, P.2    Scharton-Kersten, T.M.3    Staudt, L.4    Lenardo, M.5
  • 20
    • 33646399715 scopus 로고    scopus 로고
    • Establishment of perineural invasion models and analysis of gene expression revealed an invariant chain (CD74) as a possible molecule involved in perineural invasion in pancreatic cancer
    • Koide N., Yamada T., Shibata R., Mori T., Fukuma M., Yamazaki K., et al. Establishment of perineural invasion models and analysis of gene expression revealed an invariant chain (CD74) as a possible molecule involved in perineural invasion in pancreatic cancer. Clin Cancer Res 12 8 (2006) 2419-2426
    • (2006) Clin Cancer Res , vol.12 , Issue.8 , pp. 2419-2426
    • Koide, N.1    Yamada, T.2    Shibata, R.3    Mori, T.4    Fukuma, M.5    Yamazaki, K.6
  • 22
    • 34547957796 scopus 로고    scopus 로고
    • Flesh and blood: the story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies
    • Katzav S. Flesh and blood: the story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies. Cancer Lett 255 2 (2007) 241-254
    • (2007) Cancer Lett , vol.255 , Issue.2 , pp. 241-254
    • Katzav, S.1
  • 23
    • 0037147241 scopus 로고    scopus 로고
    • Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways
    • Groysman M., Hornstein I., Alcover A., and Katzav S. Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways. J Biol Chem 277 51 (2002) 50121-50130
    • (2002) J Biol Chem , vol.277 , Issue.51 , pp. 50121-50130
    • Groysman, M.1    Hornstein, I.2    Alcover, A.3    Katzav, S.4
  • 24
    • 0033956628 scopus 로고    scopus 로고
    • Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation
    • Groysman M., Russek C.S., and Katzav S. Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation. FEBS Lett 467 1 (2000) 75-80
    • (2000) FEBS Lett , vol.467 , Issue.1 , pp. 75-80
    • Groysman, M.1    Russek, C.S.2    Katzav, S.3
  • 25
    • 25144461596 scopus 로고    scopus 로고
    • VAV1: a new target in pancreatic cancer?
    • Denicola G., and Tuveson D.A. VAV1: a new target in pancreatic cancer?. Cancer Biol Ther 4 5 (2005) 509-511
    • (2005) Cancer Biol Ther , vol.4 , Issue.5 , pp. 509-511
    • Denicola, G.1    Tuveson, D.A.2
  • 27
    • 60349115007 scopus 로고    scopus 로고
    • Vav1: a hematopoietic signal transduction molecule involved in human malignancies
    • Katzav S. Vav1: a hematopoietic signal transduction molecule involved in human malignancies. Int J Biochem Cell Biol 41 6 (2009) 1245-1248
    • (2009) Int J Biochem Cell Biol , vol.41 , Issue.6 , pp. 1245-1248
    • Katzav, S.1
  • 28
    • 70350218798 scopus 로고    scopus 로고
    • TrkBT1 induces liver metastasis of pancreatic cancer cells by sequestering Rho GDP dissociation inhibitor and promoting RhoA activation
    • Li Z., Chang Z., Chiao L.J., Kang Y., Xia Q., Zhu C., et al. TrkBT1 induces liver metastasis of pancreatic cancer cells by sequestering Rho GDP dissociation inhibitor and promoting RhoA activation. Cancer Res 69 19 (2009) 7851-7859
    • (2009) Cancer Res , vol.69 , Issue.19 , pp. 7851-7859
    • Li, Z.1    Chang, Z.2    Chiao, L.J.3    Kang, Y.4    Xia, Q.5    Zhu, C.6
  • 29
    • 13844297410 scopus 로고    scopus 로고
    • A truncated tropomyosin-related kinase B receptor, T1, regulates glial cell morphology via Rho GDP dissociation inhibitor 1
    • Ohira K., Kumanogoh H., Sahara Y., Homma K.J., Hirai H., Nakamura S., et al. A truncated tropomyosin-related kinase B receptor, T1, regulates glial cell morphology via Rho GDP dissociation inhibitor 1. J Neurosci 25 6 (2005) 1343-1353
    • (2005) J Neurosci , vol.25 , Issue.6 , pp. 1343-1353
    • Ohira, K.1    Kumanogoh, H.2    Sahara, Y.3    Homma, K.J.4    Hirai, H.5    Nakamura, S.6
  • 30
    • 0037408391 scopus 로고    scopus 로고
    • The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI
    • Yamashita T., and Tohyama M. The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. Nat Neurosci 6 5 (2003) 461-467
    • (2003) Nat Neurosci , vol.6 , Issue.5 , pp. 461-467
    • Yamashita, T.1    Tohyama, M.2
  • 31
    • 0037048326 scopus 로고    scopus 로고
    • Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters
    • Fritz G., Brachetti C., Bahlmann F., Schmidt M., and Kaina B. Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Br J Cancer 87 6 (2002) 635-644
    • (2002) Br J Cancer , vol.87 , Issue.6 , pp. 635-644
    • Fritz, G.1    Brachetti, C.2    Bahlmann, F.3    Schmidt, M.4    Kaina, B.5
  • 32
    • 0347594125 scopus 로고    scopus 로고
    • Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers
    • Jiang W.G., Watkins G., Lane J., Cunnick G.H., Douglas-Jones A., Mokbel K., et al. Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers. Clin Cancer Res 9 17 (2003) 6432-6440
    • (2003) Clin Cancer Res , vol.9 , Issue.17 , pp. 6432-6440
    • Jiang, W.G.1    Watkins, G.2    Lane, J.3    Cunnick, G.H.4    Douglas-Jones, A.5    Mokbel, K.6
  • 33
    • 34548052025 scopus 로고    scopus 로고
    • Biphasic expression of RhoGDI2 in the progression of breast cancer and its negative relation with lymph node metastasis
    • Hu L.D., Zou H.F., Zhan S.X., and Cao K.M. Biphasic expression of RhoGDI2 in the progression of breast cancer and its negative relation with lymph node metastasis. Oncol Rep 17 6 (2007) 1383-1389
    • (2007) Oncol Rep , vol.17 , Issue.6 , pp. 1383-1389
    • Hu, L.D.1    Zou, H.F.2    Zhan, S.X.3    Cao, K.M.4
  • 34
    • 0034659739 scopus 로고    scopus 로고
    • Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b
    • Schnelzer A., Prechtel D., Knaus U., Dehne K., Gerhard M., Graeff H., et al. Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b. Oncogene 19 26 (2000) 3013-3020
    • (2000) Oncogene , vol.19 , Issue.26 , pp. 3013-3020
    • Schnelzer, A.1    Prechtel, D.2    Knaus, U.3    Dehne, K.4    Gerhard, M.5    Graeff, H.6
  • 35
    • 0347379871 scopus 로고    scopus 로고
    • Tumor-related alternatively spliced Rac1b is not regulated by Rho-GDP dissociation inhibitors and exhibits selective downstream signaling
    • Matos P., Collard J.G., and Jordan P. Tumor-related alternatively spliced Rac1b is not regulated by Rho-GDP dissociation inhibitors and exhibits selective downstream signaling. J Biol Chem 278 50 (2003) 50442-50448
    • (2003) J Biol Chem , vol.278 , Issue.50 , pp. 50442-50448
    • Matos, P.1    Collard, J.G.2    Jordan, P.3
  • 36
    • 11244313840 scopus 로고    scopus 로고
    • Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation
    • Singh A., Karnoub A.E., Palmby T.R., Lengyel E., Sondek J., and Der C.J. Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation. Oncogene 23 58 (2004) 9369-9380
    • (2004) Oncogene , vol.23 , Issue.58 , pp. 9369-9380
    • Singh, A.1    Karnoub, A.E.2    Palmby, T.R.3    Lengyel, E.4    Sondek, J.5    Der, C.J.6
  • 37
    • 36348938027 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is a target gene of rho GDP dissociation inhibitor beta in breast cancer cells
    • Schunke D., Span P., Ronneburg H., Dittmer A., Vetter M., Holzhausen H.J., et al. Cyclooxygenase-2 is a target gene of rho GDP dissociation inhibitor beta in breast cancer cells. Cancer Res 67 22 (2007) 10694-10702
    • (2007) Cancer Res , vol.67 , Issue.22 , pp. 10694-10702
    • Schunke, D.1    Span, P.2    Ronneburg, H.3    Dittmer, A.4    Vetter, M.5    Holzhausen, H.J.6
  • 38
    • 13844310310 scopus 로고    scopus 로고
    • Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer
    • Wang Y., Klijn J.G., Zhang Y., Sieuwerts A.M., Look M.P., Yang F., et al. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet 365 9460 (2005) 671-679
    • (2005) Lancet , vol.365 , Issue.9460 , pp. 671-679
    • Wang, Y.1    Klijn, J.G.2    Zhang, Y.3    Sieuwerts, A.M.4    Look, M.P.5    Yang, F.6
  • 39
    • 33645825388 scopus 로고    scopus 로고
    • Multicenter validation of a gene expression-based prognostic signature in lymph node-negative primary breast cancer
    • Foekens J.A., Atkins D., Zhang Y., Sweep F.C., Harbeck N., Paradiso A., et al. Multicenter validation of a gene expression-based prognostic signature in lymph node-negative primary breast cancer. J Clin Oncol 24 11 (2006) 1665-1671
    • (2006) J Clin Oncol , vol.24 , Issue.11 , pp. 1665-1671
    • Foekens, J.A.1    Atkins, D.2    Zhang, Y.3    Sweep, F.C.4    Harbeck, N.5    Paradiso, A.6
  • 40
    • 34250652449 scopus 로고    scopus 로고
    • Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series
    • Desmedt C., Piette F., Loi S., Wang Y., Lallemand F., Haibe-Kains B., et al. Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series. Clin Cancer Res 13 11 (2007) 3207-3214
    • (2007) Clin Cancer Res , vol.13 , Issue.11 , pp. 3207-3214
    • Desmedt, C.1    Piette, F.2    Loi, S.3    Wang, Y.4    Lallemand, F.5    Haibe-Kains, B.6
  • 41
    • 0035793554 scopus 로고    scopus 로고
    • Rho GTPases as modulators of the estrogen receptor transcriptional response
    • Su L.F., Knoblauch R., and Garabedian M.J. Rho GTPases as modulators of the estrogen receptor transcriptional response. J Biol Chem 276 5 (2001) 3231-3237
    • (2001) J Biol Chem , vol.276 , Issue.5 , pp. 3231-3237
    • Su, L.F.1    Knoblauch, R.2    Garabedian, M.J.3
  • 42
    • 0037020165 scopus 로고    scopus 로고
    • Regulation of GRIP1 and CBP Coactivator activity by Rho GDI modulates estrogen receptor transcriptional enhancement
    • Su L.F., Wang Z., and Garabedian M.J. Regulation of GRIP1 and CBP Coactivator activity by Rho GDI modulates estrogen receptor transcriptional enhancement. J Biol Chem 277 40 (2002) 37037-37044
    • (2002) J Biol Chem , vol.277 , Issue.40 , pp. 37037-37044
    • Su, L.F.1    Wang, Z.2    Garabedian, M.J.3
  • 43
    • 35748970765 scopus 로고    scopus 로고
    • Rho GDP dissociation inhibitor alpha interacts with estrogen receptor alpha and influences estrogen responsiveness
    • El Marzouk S., Schultz-Norton J.R., Likhite V.S., McLeod I.X., Yates J.R., and Nardulli A.M. Rho GDP dissociation inhibitor alpha interacts with estrogen receptor alpha and influences estrogen responsiveness. J Mol Endocrinol 39 4 (2007) 249-259
    • (2007) J Mol Endocrinol , vol.39 , Issue.4 , pp. 249-259
    • El Marzouk, S.1    Schultz-Norton, J.R.2    Likhite, V.S.3    McLeod, I.X.4    Yates, J.R.5    Nardulli, A.M.6
  • 44
    • 22244467726 scopus 로고    scopus 로고
    • Rho GDP dissociation inhibitor protects cancer cells against drug-induced apoptosis
    • Zhang B., Zhang Y., Dagher M.C., and Shacter E. Rho GDP dissociation inhibitor protects cancer cells against drug-induced apoptosis. Cancer Res 65 14 (2005) 6054-6062
    • (2005) Cancer Res , vol.65 , Issue.14 , pp. 6054-6062
    • Zhang, B.1    Zhang, Y.2    Dagher, M.C.3    Shacter, E.4
  • 45
    • 33846685107 scopus 로고    scopus 로고
    • Reduced expression of Rho guanine nucleotide dissociation inhibitor-alpha modulates the cytotoxic effect of busulfan in HEK293 cells
    • Reimer J., Bien S., Sonnemann J., Beck J.F., Wieland T., Kroemer H.K., et al. Reduced expression of Rho guanine nucleotide dissociation inhibitor-alpha modulates the cytotoxic effect of busulfan in HEK293 cells. Anticancer Drugs 18 3 (2007) 333-340
    • (2007) Anticancer Drugs , vol.18 , Issue.3 , pp. 333-340
    • Reimer, J.1    Bien, S.2    Sonnemann, J.3    Beck, J.F.4    Wieland, T.5    Kroemer, H.K.6
  • 46
    • 34548412580 scopus 로고    scopus 로고
    • RhoGDI2: a new metastasis suppressor gene: discovery and clinical translation
    • Harding M.A., and Theodorescu D. RhoGDI2: a new metastasis suppressor gene: discovery and clinical translation. Urol Oncol 25 5 (2007) 401-406
    • (2007) Urol Oncol , vol.25 , Issue.5 , pp. 401-406
    • Harding, M.A.1    Theodorescu, D.2
  • 47
    • 0034842795 scopus 로고    scopus 로고
    • The relationship of BRMS1 and RhoGDI2 gene expression to metastatic potential in lineage related human bladder cancer cell lines
    • Seraj M.J., Harding M.A., Gildea J.J., Welch D.R., and Theodorescu D. The relationship of BRMS1 and RhoGDI2 gene expression to metastatic potential in lineage related human bladder cancer cell lines. Clin Exp Metastasis 18 6 (2000) 519-525
    • (2000) Clin Exp Metastasis , vol.18 , Issue.6 , pp. 519-525
    • Seraj, M.J.1    Harding, M.A.2    Gildea, J.J.3    Welch, D.R.4    Theodorescu, D.5
  • 48
    • 2542606977 scopus 로고    scopus 로고
    • Reduced expression of metastasis suppressor RhoGDI2 is associated with decreased survival for patients with bladder cancer
    • Theodorescu D., Sapinoso L.M., Conaway M.R., Oxford G., Hampton G.M., and Frierson Jr. H.F. Reduced expression of metastasis suppressor RhoGDI2 is associated with decreased survival for patients with bladder cancer. Clin Cancer Res 10 11 (2004) 3800-3806
    • (2004) Clin Cancer Res , vol.10 , Issue.11 , pp. 3800-3806
    • Theodorescu, D.1    Sapinoso, L.M.2    Conaway, M.R.3    Oxford, G.4    Hampton, G.M.5    Frierson Jr., H.F.6
  • 50
    • 33750522653 scopus 로고    scopus 로고
    • Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling
    • DerMardirossian C., Rocklin G., Seo J.Y., and Bokoch G.M. Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling. Mol Biol Cell 17 11 (2006) 4760-4768
    • (2006) Mol Biol Cell , vol.17 , Issue.11 , pp. 4760-4768
    • DerMardirossian, C.1    Rocklin, G.2    Seo, J.Y.3    Bokoch, G.M.4
  • 51
    • 66149117890 scopus 로고    scopus 로고
    • Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases
    • Moissoglu K., McRoberts K.S., Meier J.A., Theodorescu D., and Schwartz M.A. Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases. Cancer Res 69 7 (2009) 2838-2844
    • (2009) Cancer Res , vol.69 , Issue.7 , pp. 2838-2844
    • Moissoglu, K.1    McRoberts, K.S.2    Meier, J.A.3    Theodorescu, D.4    Schwartz, M.A.5
  • 52
    • 23844468385 scopus 로고    scopus 로고
    • Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2
    • Titus B., Frierson Jr. H.F., Conaway M., Ching K., Guise T., Chirgwin J., et al. Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2. Cancer Res 65 16 (2005) 7320-7327
    • (2005) Cancer Res , vol.65 , Issue.16 , pp. 7320-7327
    • Titus, B.1    Frierson Jr., H.F.2    Conaway, M.3    Ching, K.4    Guise, T.5    Chirgwin, J.6
  • 53
    • 33846846542 scopus 로고    scopus 로고
    • Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia
    • Wu Y., McRoberts K., Berr S.S., Frierson Jr. H.F., Conaway M., and Theodorescu D. Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia. Oncogene 26 5 (2007) 765-773
    • (2007) Oncogene , vol.26 , Issue.5 , pp. 765-773
    • Wu, Y.1    McRoberts, K.2    Berr, S.S.3    Frierson Jr., H.F.4    Conaway, M.5    Theodorescu, D.6
  • 54
    • 2642553111 scopus 로고    scopus 로고
    • Neuromedin U and its receptors: structure, function, and physiological roles
    • Brighton P.J., Szekeres P.G., and Willars G.B. Neuromedin U and its receptors: structure, function, and physiological roles. Pharmacol Rev 56 2 (2004) 231-248
    • (2004) Pharmacol Rev , vol.56 , Issue.2 , pp. 231-248
    • Brighton, P.J.1    Szekeres, P.G.2    Willars, G.B.3
  • 56
    • 67649853052 scopus 로고    scopus 로고
    • Discovery and pharmacological characterization of a small-molecule antagonist at neuromedin U receptor NMUR2
    • Liu J.J., Payza K., Huang J., Liu R., Chen T., Coupal M., et al. Discovery and pharmacological characterization of a small-molecule antagonist at neuromedin U receptor NMUR2. J Pharmacol Exp Ther 330 1 (2009) 268-275
    • (2009) J Pharmacol Exp Ther , vol.330 , Issue.1 , pp. 268-275
    • Liu, J.J.1    Payza, K.2    Huang, J.3    Liu, R.4    Chen, T.5    Coupal, M.6
  • 57
    • 43049100321 scopus 로고    scopus 로고
    • The endothelin axis in cancer
    • Bagnato A., and Rosano L. The endothelin axis in cancer. Int J Biochem Cell Biol 40 8 (2008) 1443-1451
    • (2008) Int J Biochem Cell Biol , vol.40 , Issue.8 , pp. 1443-1451
    • Bagnato, A.1    Rosano, L.2
  • 58
    • 36849008609 scopus 로고    scopus 로고
    • Endothelin receptor antagonists in cancer therapy
    • Lalich M., McNeel D.G., Wilding G., and Liu G. Endothelin receptor antagonists in cancer therapy. Cancer Invest 25 8 (2007) 785-794
    • (2007) Cancer Invest , vol.25 , Issue.8 , pp. 785-794
    • Lalich, M.1    McNeel, D.G.2    Wilding, G.3    Liu, G.4
  • 59
    • 35648968713 scopus 로고    scopus 로고
    • A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer
    • Carducci M.A., Saad F., Abrahamsson P.A., Dearnaley D.P., Schulman C.C., North S.A., et al. A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer. Cancer 110 9 (2007) 1959-1966
    • (2007) Cancer , vol.110 , Issue.9 , pp. 1959-1966
    • Carducci, M.A.1    Saad, F.2    Abrahamsson, P.A.3    Dearnaley, D.P.4    Schulman, C.C.5    North, S.A.6
  • 60
    • 55549112219 scopus 로고    scopus 로고
    • Phase 3, randomized, controlled trial of atrasentan in patients with nonmetastatic, hormone-refractory prostate cancer
    • Nelson J.B., Love W., Chin J.L., Saad F., Schulman C.C., Sleep D.J., et al. Phase 3, randomized, controlled trial of atrasentan in patients with nonmetastatic, hormone-refractory prostate cancer. Cancer 113 9 (2008) 2478-2487
    • (2008) Cancer , vol.113 , Issue.9 , pp. 2478-2487
    • Nelson, J.B.1    Love, W.2    Chin, J.L.3    Saad, F.4    Schulman, C.C.5    Sleep, D.J.6
  • 61
    • 62649134676 scopus 로고    scopus 로고
    • Safety and efficacy of the specific endothelin-A receptor antagonist ZD4054 in patients with hormone-resistant prostate cancer and bone metastases who were pain free or mildly symptomatic: a double-blind, placebo-controlled, randomised, phase 2 trial
    • James N.D., Caty A., Borre M., Zonnenberg B.A., Beuzeboc P., Morris T., et al. Safety and efficacy of the specific endothelin-A receptor antagonist ZD4054 in patients with hormone-resistant prostate cancer and bone metastases who were pain free or mildly symptomatic: a double-blind, placebo-controlled, randomised, phase 2 trial. Eur Urol 55 5 (2009) 1112-1123
    • (2009) Eur Urol , vol.55 , Issue.5 , pp. 1112-1123
    • James, N.D.1    Caty, A.2    Borre, M.3    Zonnenberg, B.A.4    Beuzeboc, P.5    Morris, T.6


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