Inducement of mitosis delay by cucurbitacin E, a novel tetracyclic triterpene from climbing stem of Cucumis melo L., through GADD45γ in human brain malignant glioma (GBM) 8401 cells

Cell Death and Disease

Volumn 5, Issue 2, 2014, Pages

  Hsu, Y C ^a   Chen, M J ^b   Huang, T Y ^a,c  

^a CHANG JUNG CHRISTIAN UNIVERSITY   (Taiwan)

^b CHI MEI MEDICAL CENTER   (Taiwan)

^c TAINAN SIN LAU HOSPITAL   (Taiwan)

Author keywords

cucurbitacin E (CuE); G2 M arrest; growth arrest and DNA damage 45 (GADD45); malignant glioma

Indexed keywords

ANTINEOPLASTIC AGENT; CUCURBITACIN E; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45 GAMMA; PROTEIN P53; TRITERPENOID; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL CYCLE REGULATION; CELL PROLIFERATION; CELL SURVIVAL; DRUG CYTOTOXICITY; DRUG MECHANISM; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENETIC ASSOCIATION; GLIOBLASTOMA; M PHASE CELL CYCLE CHECKPOINT; MELON; METAPHASE; MITOSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION;

ANTIMITOTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTATIONAL BIOLOGY; CUCUMIS MELO; CYCLIN B; DOSE-RESPONSE RELATIONSHIP, DRUG; G2 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REGULATORY NETWORKS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOSIS; NEUROBLASTOMA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHYTOTHERAPY; PLANT STEMS; PLANTS, MEDICINAL; PROTEIN BINDING; SIGNAL TRANSDUCTION; TRITERPENES; UP-REGULATION;

EID: 84896750733     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.22     Document Type: Article

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