The cucurbitacins E, D and I: Investigation of their cytotoxicity toward human chondrosarcoma SW 1353 cell line and their biotransformation in man liver

Toxicology Letters

Volumn 216, Issue 2-3, 2013, Pages 189-199

  Abbas, Suzanne ^a   Vincourt, Jean Baptiste ^a   Habib, Lamice ^b   Netter, Patrick ^a   Greige Gerges, Hélène ^b   Magdalou, Jacques ^a  

^a Biopôle de l Université de Lorraine   (France)

^b LEBANESE UNIVERSITY   (Lebanon)

Author keywords

Chondrosarcoma; Cucurbitacin; Cytotoxicity; Glucuronidation; Hydroxylation; Sulfation

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CUCURBITACIN; CUCURBITACIN D; CUCURBITACIN E; CUCURBITACIN I; CYTOCHALASIN D; GLUCURONOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CELL STRAIN; CELL STRAIN SW 1353; CHONDROSARCOMA; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG EFFECT; DRUG GLUCURONIDATION; DRUG HYDROLYSIS; DRUG HYDROXYLATION; DRUG SULFATION; DRUG TRANSFORMATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; BONE NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; CHONDROSARCOMA; CUCURBITACINS; DNA FRAGMENTATION; FEMALE; GLUCURONOSYLTRANSFERASE; HUMANS; IN SITU NICK-END LABELING; INHIBITORY CONCENTRATION 50; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84871543856     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.11.014     Document Type: Article

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