(5-Hydroxy-4-oxo-4H-pyran-2-yl)methyl 6-hydroxynaphthalene-2-carboxylate, a kojic acid derivative, inhibits inflammatory mediator production via the suppression of Syk/Src and NF-κB activation

International Immunopharmacology

Volumn 20, Issue 1, 2014, Pages 37-45

  Dung, To Thi Mai ^a   Kim, Seung Cheol ^b   Yoo, Byong Chul ^c   Sung, Gi Ho ^d   Yang, Woo Seok ^a   Kim, Han Gyung ^a   Park, Jae Gwang ^a   Rhee, Man Hee ^e   Park, Kye Won ^a   Yoon, Keejung ^a   Lee, Yunmi ^f   Hong, Sungyoul ^a   Kim, Jong Hoon ^g   Cho, Jae Youl ^a  

^a Sungkyunkwan University   (South Korea)

^b Ewha Womans University School of Medicine   (South Korea)

^c National Cancer Center   (South Korea)

^d Rural Development Administration   (South Korea)

^e Kyungpook National University   (South Korea)

^f Kwangwoon University   (South Korea)

^g Chonbuk National University   (South Korea)

Author keywords

(5 Hydroxy 4 oxo 4H pyran 2 yl)methyl 6 hydroxynaphthalene 2 carboxylate; Anti inflammatory effect; NF B; Src; Syk

Indexed keywords

(5 HYDROXY 4 OXO EH PYRAN 2 YL)METHYL 6 HYDROXYNAPHTHALENE 2 CARBOXYLATE; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; KOJIC ACID; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROSTAGLANDIN E; PROTEIN KINASE B; PROTEIN KINASE SYK INHIBITOR; PROTEIN TYROSINE KINASE; RANITIDINE; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; (5-HYDROXY-4-OXO-4H-PYRAN-2-YL)METHYL 6-HYDROXYNAPHTHALENE-2-CARBOXYLATE; ALCOHOL; HYDROCHLORIC ACID; I KAPPA B; NAPHTHOL DERIVATIVE; NF-KAPPAB INHIBITOR ALPHA; NOS2 PROTEIN, MOUSE; PROSTAGLANDIN E2; PROTEIN KINASE SYK; PTGS2 PROTEIN, MOUSE; PYRONE DERIVATIVE; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PURIFICATION; EXPERIMENTAL GASTRITIS; GENE OVEREXPRESSION; GENE TRANSLOCATION; IMMUNOPHARMACOLOGY; IN VITRO STUDY; IN VIVO STUDY; LUCIFERASE ASSAY; MALE; MEDIATOR RELEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; STOMACH; TRANSCRIPTION INITIATION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL SURVIVAL; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; GASTRITIS; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PATHOLOGY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE 2; DINOPROSTONE; ETHANOL; GASTRITIS; HEK293 CELLS; HUMANS; HYDROCHLORIC ACID; I-KAPPA B PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE, INBRED ICR; NAPHTHOLS; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN-TYROSINE KINASES; PYRONES; SRC-FAMILY KINASES; STOMACH;

EID: 84896748350     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2014.02.019     Document Type: Article

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