Deficiency of the myeloid differentiation primary response molecule MyD88 leads to an early and rapid development of Helicobacter-induced gastric malignancy

Infection and Immunity

Volumn 82, Issue 1, 2014, Pages 356-363

  Banerjee, Anirban ^a,f   Thamphiwatana, Soracha ^b   Carmona, Ellese M ^a   Rickman, Barry ^c   Doran, Kelly S ^a,d   Obonyo, Marygorret ^e  

^a SAN DIEGO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c BHR Comparative Pathology   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 18; INTERLEUKIN 6; MYELOID DIFFERENTIATION FACTOR 88; RNA; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIUM ADHERENCE; BACTERIUM CULTURE; CANCER MODEL; CELL PROLIFERATION; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOKINE RELEASE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HISTOPATHOLOGY; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRECANCER; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH ADENOCARCINOMA; STOMACH CANCER; STOMACH CARCINOGENESIS; STOMACH MUCOSA;

EID: 84890843760     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01344-13     Document Type: Article

References (43)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. 2011. Global cancer statistics. CA Cancer J. Clin. 61:69-90. http://dx.doi.org/10.3322/caac.20107.
2. IARC. 1994. Schistomes, liver flukes and Helicobacter pylori. IARC Monogr. Eval. Carcinog. Risks Hum. 61:1-241.
3. Peek RM, Jr, Blaser MJ. 2002. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat. Rev. Cancer 2:28-37. http://dx.doi.org/10.1038/nrc703.
4. Coussens LM, Werb Z. 2002. Inflammation and cancer. Nature 420:860-867. http://dx.doi.org/10.1038/nature01322.
5. Balkwill F, Mantovani A. 2001. Inflammation and cancer: back to Virchow? Lancet 357:539-545. http://dx.doi.org/10.1016/S0140-6736(00)04046-0.
6. Janssens S, Beyaert R. 2002. A universal role for MyD88 in TLR/IL-1Rmediated signaling. Trends Biochem. Sci. 27:474-482. http://dx.doi.org/10.1016/S0968-0004(02)02145-X.
7. Akira S, Takeda K. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4:499-511. http://dx.doi.org/10.1038/nri1391.
8. Loiarro M, Ruggiero V, Sette C. 2010. Targeting TLR/IL-1R signalling in human diseases. Mediators Inflamm. 2010:674363. http://dx.doi.org/10.1155/2010/674363.
9. Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, Karin M. 2007. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317:121-124. http://dx.doi.org/10.1126/science.1140485.
10. Uronis JM, Muhlbauer M, Herfarth HH, Rubinas TC, Jones GS, Jobin C. 2009. Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility. PLoS One 4:e6026. http://dx.doi.org/10.1371/journal.pone.0006026.
11. Swann JB, Vesely MD, Silva A, Sharkey J, Akira S, Schreiber RD, Smyth MJ. 2008. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 105:652-656. http://dx.doi.org/10.1073/pnas.0708594105.
12. Ochi A, Nguyen AH, Bedrosian AS, Mushlin HM, Zarbakhsh S, Barilla R, Zambirinis CP, Fallon NC, Rehman A, Pylayeva-Gupta Y, Badar S, Hajdu CH, Frey AB, Bar-Sagi D, Miller G. 2012. MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J. Exp. Med. 209:1671-1687. http://dx.doi.org/10.1084/jem.20111706.
13. Salcedo R, Worschech A, Cardone M, Jones Y, Gyulai Z, Dai RM, Wang E, Ma W, Haines D, O'Huigin C, Marincola FM, Trinchieri G. 2010. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J. Exp. Med. 207:1625-1636. http://dx.doi.org/10.1084/jem.20100199.
14. Salcedo R, Cataisson C, Hasan U, Yuspa SH, Trinchieri G. 2013. MyD88 and its divergent toll in carcinogenesis. Trends Immunol. 34:379-389. http://dx.doi.org/10.1016/j.it.2013.03.008.
15. Rad R, Ballhorn W, Voland P, Eisenacher K, Mages J, Rad L, Ferstl R, Lang R, Wagner H, Schmid RM, Bauer S, Prinz C, Kirschning CJ, Krug A. 2009. Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori. Gastroenterology 136:2247-2257. http://dx.doi.org/10.1053/j.gastro.2009.02.066.
16. Obonyo M, Rickman B, Guiney DG. 2011. Effects of myeloid differentiation primary response gene 88 (MyD88) activation on Helicobacter infection in vivo and induction of a Th17 response. Helicobacter 16:398-404. http://dx.doi.org/10.1111/j.1523-5378.2011.00861.x.
17. Obonyo M, Sabet M, Cole SP, Ebmeyer J, Uematsu S, Akira S, Guiney DG. 2007. Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori. Infect. Immun. 75:2408-2414. http://dx.doi.org/10.1128/IAI.01794-06.
18. Rogers AB, Taylor NS, Whary MT, Stefanich ED, Wang TC, Fox JG. 2005. Helicobacter pylori but not high salt induces gastric intraepithelial neoplasia in B6129 mice. Cancer Res. 65:10709-10715. http://dx.doi.org/10.1158/0008-5472.CAN-05-1846.
19. Cai X, Carlson J, Stoicov C, Li H, Wang TC, Houghton J. 2005. Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice. Gastroenterology 128:1937-1952. http://dx.doi.org/10.1053/j.gastro.2005.02.066.
20. Houghton J, Stoicov C, Nomura S, Rogers AB, Carlson J, Li H, Cai X, Fox JG, Goldenring JR, Wang TC. 2004. Gastric cancer originating from bone marrow-derived cells. Science 306:1568-1571. http://dx.doi.org/10.1126/science.1099513.
21. Correa P, Houghton J. 2007. Carcinogenesis of Helicobacter pylori. Gastroenterology 133:659-672. http://dx.doi.org/10.1053/j.gastro.2007.06.026.
22. Tu SP, Quante M, Bhagat G, Takaishi S, Cui G, Yang XD, Muthuplani S, Shibata W, Fox JG, Pritchard DM, Wang TC. 2011. IFN-gamma inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis. Cancer Res. 71:4247-4259. http://dx.doi.org/10.1158/0008-5472.CAN-10-4009.
23. Shibata W, Takaishi S, Muthupalani S, Pritchard DM, Whary MT, Rogers AB, Fox JG, Betz KS, Kaestner KH, Karin M, Wang TC. 2010. Conditional deletion of IkappaB-kinase-beta accelerates Helicobacterdependent gastric apoptosis, proliferation, and preneoplasia. Gastroenterology 138:1022-1034 e1-10. http://dx.doi.org/10.1053/j.gastro.2009.11.054.
24. Fox JG, Wang TC. 2007. Inflammation, atrophy, and gastric cancer. J. Clin. Invest. 117:60-69. http://dx.doi.org/10.1172/JCI30111.
25. Moss SF. 1998. Review article: cellular markers in the gastric precancerous process. Aliment. Pharmacol. Ther. 12(Suppl 1):91-109. http://dx.doi.org/10.1111/j.1365-2036.1998.00002.x.
26. Hanahan D, Weinberg RA. 2000. The hallmarks of cancer. Cell 100:57-70. http://dx.doi.org/10.1016/S0092-8674(00)81683-9.
27. Rad R, Brenner L, Krug A, Voland P, Mages J, Lang R, Schwendy S, Reindl W, Dossumbekova A, Ballhorn W, Wagner H, Schmid RM, Bauer S, Prinz C. 2007. Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunity to Helicobacter pylori. Gastroenterology 133:150-163 e3. http://dx.doi.org/10.1053/j.gastro.2007.04.071.
28. Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A. 2009. Cancerrelated inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 30:1073-1081. http://dx.doi.org/10.1093/carcin/bgp127.
29. Correa P. 1988. A human model of gastric carcinogenesis. Cancer Res. 48:3554-3560.
30. Jones NL, Shannon PT, Cutz E, Yeger H, Sherman PM. 1997. Increase in proliferation and apoptosis of gastric epithelial cells early in the natural history of Helicobacter pylori infection. Am. J. Pathol. 151:1695-1703.
31. Maeda S, Kamata H, Luo JL, Leffert H, Karin M. 2005. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121:977-990. http://dx.doi.org/10.1016/j.cell.2005.04.014.
32. Nickoloff BJ, Ben-Neriah Y, Pikarsky E. 2005. Inflammation and cancer: is the link as simple as we think? J. Investig. Dermatol. 124:x-xiv. http://dx.doi.org/10.1111/j.0022-202X.2005.23724.x.
33. Perryman SV, Sylvester KG. 2006. Repair and regeneration: opportunities for carcinogenesis from tissue stem cells. J. Cell. Mol. Med. 10:292-308. http://dx.doi.org/10.1111/j.1582-4934.2006.tb00400.x.
34. Takeda K, Kaisho T, Akira S. 2003. Toll-like receptors. Annu. Rev. Immunol. 21:335-376. http://dx.doi.org/10.1146/annurev.immunol.21.120601.141126.
35. Macedo L, Pinhal-Enfield G, Alshits V, Elson G, Cronstein BN, Leibovich SJ. 2007. Wound healing is impaired in MyD88-deficient mice: a role for MyD88 in the regulation of wound healing by adenosine A2A receptors. Am. J. Pathol. 171:1774-1788. http://dx.doi.org/10.2353/ajpath.2007.061048.
36. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. 2004. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 118:229-241. http://dx.doi.org/10.1016/j.cell.2004.07.002.
37. Iimuro Y, Seki E, Son G, Tsutsui H, Nakanishi K, Fujimoto J. 2007. Role of innate immune response in liver regeneration. J. Gastroenterol. Hepatol 22(Suppl 1):S57-S58. http://dx.doi.org/10.1111/j.1440-1746.2006.04651.x.
38. Kawai T, Akira S. 2006. TLR signaling. Cell Death Differ. 13:816-825. http://dx.doi.org/10.1038/sj.cdd.4401850.
39. Honda K, Takaoka A, Taniguchi T. 2006. Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors. Immunity 25:349-360. http://dx.doi.org/10.1016/j.immuni.2006.08.009.
40. Hold GL, Rabkin CS, Chow WH, Smith MG, Gammon MD, Risch HA, Vaughan TL, McColl KE, Lissowska J, Zatonski W, Schoenberg JB, Blot WJ, Mowat NA, Fraumeni JF, Jr, El-Omar EM. 2007. A functional polymorphism of Toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors. Gastroenterology 132:905-912. http://dx.doi.org/10.1053/j.gastro.2006.12.026.
41. Ohara T, Morishita T, Suzuki H, Hibi T. 2006. Heterozygous Thr 135 Ala polymorphism at leucine-rich repeat (LRR) in genomic DNA of Tolllike receptor 4 in patients with poorly-differentiated gastric adenocarcinomas. Int. J. Mol. Med. 18:59-63.
42. van Pesch V, Lanaya H, Renauld JC, Michiels T. 2004. Characterization of the murine alpha interferon gene family. J. Virol. 78:8219-8228. http://dx.doi.org/10.1128/JVI.78.15.8219-8228.2004.
43. Kim KI, Malakhova OA, Hoebe K, Yan M, Beutler B, Zhang DE. 2005. Enhanced antibacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulating type I IFN signaling. J. Immunol. 175:847-854.