Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 11, 2013, Pages 3325-3328

  Goto, Taiji ^a,b   Shiina, Akiko ^a   Yoshino, Toshiharu ^a   Mizukami, Kiyoshi ^a   Hirahara, Kazuki ^a   Suzuki, Osamu ^a   Sogawa, Yoshitaka ^a   Takahashi, Tomoko ^a   Mikkaichi, Tsuyoshi ^a   Nakao, Naoki ^a   Takahashi, Mizuki ^a   Hasegawa, Masashi ^a   Sasaki, Shigeki ^b  

^a DAIICHI SANKYO CO   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

2 Phenylpyrimidine; Anti inflammatory agent; cAMP; COPD; Crystallography; PDE4; PDE4 inhibitor; PDE4B

Indexed keywords

2 PHENYL 4 PIPERIDINYL 6,7 DIHYDROTHIENO[3,4 D]PYRIMIDINE DERIVATIVE; 4 AMINO 2 PHENYLPYRIMIDINE DERIVATIVE; 5,5 DIOXO 7,8 DIHYDRO 6H THIOPYRANO[3,2 D]PYRIMIDINE DERIVATIVE; N PROPYLACETAMIDE DERIVATIVE; PHOSPHODIESTERASE IV B INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; PYRIMIDINE DERIVATIVE; ROFLUMILAST; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOKINE PRODUCTION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; EXPERIMENTAL MODEL; IC 50; MOUSE; NONHUMAN; RESPIRATORY TRACT INFLAMMATION; SPLEEN CELL; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZENEACETAMIDES; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; CYCLIC S-OXIDES; HUMANS; LIPOPOLYSACCHARIDES; LUNG DISEASES; MICE; PHOSPHODIESTERASE 4 INHIBITORS; PROTEIN BINDING; PYRIMIDINES; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 84877582531     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.03.104     Document Type: Article

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