7-Phenyl-imidazoquinolin-4(5H)-one derivatives as selective and orally available mPGES-1 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 11, 2013, Pages 2868-2878

  Shiro, Tomoya ^a   Kakiguchi, Keisuke ^a   Takahashi, Hirotada ^a   Nagata, Hidetaka ^a   Tobe, Masanori ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Imidazoquinolin 4(5H) one; mPGES 1; Oral absorption; PGE2

Indexed keywords

2 (2 CHLORO 6 FLUOROPHENYL) 7 (2 CHLOROPHENYL)IMIDAZO[4,5 C]QUINOLIN 4(5H) ONE; 2 (2 CHLORO 6 FLUOROPHENYL) 7 (2 METHYLPHENYL)IMIDAZO[4,5 C]QUINOLIN 4(5H) ONE; 2 (2 CHLORO 6 FLUOROPHENYL) 7 (3 METHYLPHENYL)IMIDAZO[4,5 C]QUINOLIN 4(5H) ONE; 2 (2 CHLORO 6 FLUOROPHENYL) 7 (4 CHLOROPHENYL)IMIDAZO[4,5 C]QUINOLIN 4(5H) ONE; 2 (2 CHLORO 6 FLUOROPHENYL) 7 (4 METHYLPHENYL)IMIDAZO[4,5 C]QUINOLIN 4(5H) ONE; 2 (2 CHLORO 6 FLUOROPHENYL) 7 PHENYLIMIDAZO[4,5 C]QUINOLIN 4(5H) ONE; 2 (2 CHLORO 6 METHYLPHENYL) 7 PHENYLIMIDAZO[4,5 C]QUINOLIN 4(5H) ONE; 2 (2 CHLORO 6 NITROPHENYL) 7 PHENYLIMIDAZO[4,5 C]QUINOLIN 4(5H) ONE; 2 (2 CHLOROPHENYL) 7 (FURAN 2 YL)IMIDAZO[4,5 C]QUINOLIN 4(5H) ONE; 2 (2 CHLOROPHENYL) 7 (N HEXYL)IMIDAZO[4,5 C]QUINOLIN 4(5H) ONE; 2 (2 CHLOROPHENYL) 7 (N PENTYL)IMIDAZO[4,5 C]QUINOLIN 4(5H) ONE; 2 (2 CHLOROPHENYL) 7 (NAPHTHALEN 2 YL)IMIDAZO[4,5 C]QUINOLIN 4(5H) ONE; 2 (2 CHLOROPHENYL) 7 (PYRIDIN 3 YL)IMIDAZO[4,5 C]QUINOLIN 4(5H) ONE; 2 (2 CHLOROPHENYL) 7 (PYRIDIN 4 YL)IMIDAZO[4,5 C]QUINOLIN 4(5H) ONE; 2 (2 CHLOROPHENYL) 7 (THIOPHEN 2 YL)IMIDAZO[4,5 C]QUINOLIN 4(5H) ONE; 2 [2 CHLORO 6 (TRIFLUOROMETHYL)PHENYL] 7 PHENYLIMIDAZO[4,5 C]QUINOLIN 4(5H) ONE; 4 CHLORO 2 (2 CHLORO 6 FLUOROPHENYL) 7 PHENYLIMIDAZO[4,5 C]QUINOLINE; 4 CHLORO 2 (2 CHLORO 6 METHYLPHENYL) 7 PHENYLIMIDAZO[4,5 C]QUINOLINE; 4 CHLORO 2 (2 CHLORO 6 NITROPHENYL) 7 PHENYLIMIDAZO[4,5 C]QUINOLINE; 4 CHLORO 2 [2 CHLORO 6 (TRIFLUOROMETHYL)PHENYL] 7 PHENYLIMIDAZO[4,5 C]QUINOLINE; 7 (N BUTYL) 2 (2 CHLOROPHENYL)IMIDAZO[4,5 C]QUINOLIN 4(5H) ONE; 7 BENZYL 2 (2 CHLOROPHENYL)IMIDAZO[4,5 C]QUINOLIN 4(5H) ONE; 7 PHENYLIMIDAZOQUINOLIN 4(5H) ONE DERIVATIVE; BROMINE; PHENYL GROUP; PROSTAGLANDIN E2 SYNTHASE 1; PROSTAGLANDIN E2 SYNTHASE 1 INHIBITOR; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; EMBRYO; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOLOGICAL AVAILABILITY; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DISCOVERY; DRUG STABILITY; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; QUINOLONES; RATS; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 84877838014     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.03.069     Document Type: Article

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