Estrogen receptor is activated by Korean red ginseng in vitro but not in vivo

Journal of Ginseng Research

Volumn 36, Issue 2, 2012, Pages 169-175

  Shim, Myeong Kuk ^a   Lee, Young Joo ^a  

^a Sejong University   (South Korea)

Author keywords

Breast cancer cells; Estrogen receptors; Hypocholesterolemic effects; Menopause; Panax ginseng; Red ginseng

Indexed keywords

PANAX GINSENG; RATTUS;

EID: 84859617624     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.5142/jgr.2012.36.2.169     Document Type: Article

References (35)

1. Doyle BJ, Frasor J, Bellows LE, Locklear TD, Perez A, Gomez-Laurito J, Mahady GB. Estrogenic effects of herbal medicines from Costa Rica used for the management of menopausal symptoms. Menopause 2009;16:748-755.
2. Lissin LW, Cooke JP. Phytoestrogens and cardiovascular health. J Am Coll Cardiol 2000;35:1403-1410.
3. Kallen AN, Pal L. Cardiovascular disease and ovarian function. Curr Opin Obstet Gynecol 2011;23:258-267.
4. Yanes LL, Reckelhoff JF. Postmenopausal hypertension. Am J Hypertens 2011;24:740-749.
5. King J, Wynne CH, Assersohn L, Jones A. Hormone replacement therapy and women with premature menopause--a cancer survivorship issue. Eur J Cancer 2011;47:1623-1632.
6. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321-333.
7. Anderson GL, Limacher M, Assaf AR, Bassford T, Beresford SA, Black H, Bonds D, Brunner R, Brzyski R, Caan B et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA 2004;291:1701-1712.
8. This P, de Cremoux P, Leclercq G, Jacquot Y. A critical view of the effects of phytoestrogens on hot flashes and breast cancer risk. Maturitas 2011;70:222-226.
9. Zhao L, Mao Z, Brinton RD. A select combination of clinically relevant phytoestrogens enhances estrogen receptor beta-binding selectivity and neuroprotective activities in vitro and in vivo. Endocrinology 2009;150:770-783.
10. Zhao E, Mu Q. Phytoestrogen biological actions on Mammalian reproductive system and cancer growth. Sci Pharm 2011;79:1-20.
11. Xin D, Wang H, Yang J, Su YF, Fan GW, Wang YF, Zhu Y, Gao XM. Phytoestrogens from Psoralea corylifolia reveal estrogen receptor-subtype selectivity. Phytomedicine 2010;17:126-131.
12. Bolle P, Mastrangelo S, Perrone F, Evandri MG. Estrogen-like effect of a Cimicifuga racemosa extract subfraction as assessed by in vivo, ex vivo and in vitro assays. J Steroid Biochem Mol Biol 2007;107:262-269.
13. Simoncini T, Lenzi E, Zochling A, Gopal S, Goglia L, Russo E, Polak K, Casarosa E, Jungbauer A, Genazzani AD et al. Estrogen-like effects of wine extracts on nitric oxide synthesis in human endothelial cells. Maturitas 2011;70:169-175.
14. Cos P, De Bruyne T, Apers S, vanden Berghe D, Pieters L, Vlietinck AJ. Phytoestrogens: recent developments. Planta Med 2003;69:589-599.
15. Sunita P, Pattanayak SP. Phytoestrogens in postmenopausal indications: a theoretical perspective. Pharmacogn Rev 2011;5:41-47.
16. Kwak YS, Kyung JS, Kim JS, Cho JY, Rhee MH. Antihyperlipidemic effects of red ginseng acidic polysaccharide from Korean red ginseng. Biol Pharm Bull 2010;33:468-472.
17. Min SW, Jung SH, Cho KH, Kim DH. Antihyperlipidemic effects of red ginseng, crataegii fructus and their main constituents ginsenoside Rg3 and ursolic acid in mice. Biomol Ther 2008;16:364-369.
18. Cho J, Park W, Lee S, Ahn W, Lee Y. Ginsenoside-Rb1 from Panax ginseng C.A. Meyer activates estrogen receptor-alpha and -beta, independent of ligand binding. J Clin Endocrinol Metab 2004;89:3510-3515.
19. Davis VL, Jayo MJ, Ho A, Kotlarczyk MP, Hardy ML, Foster WG, Hughes CL. Black cohosh increases metastatic mammary cancer in transgenic mice expressing cerbB 2. Cancer Res 2008;68:8377-8383.
20. Jeon C, Kang S, Park S, Lim K, Hwang KW, Min H. T Cell stimulatory effects of Korean red ginseng though modulation of myeloid-derived suppressor cells. J Ginseng Res 2011;35:462-470.
21. Lau WS, Chen WF, Chan RY, Guo DA, Wong MS. Mitogen-activated protein kinase (MAPK) pathway mediates the oestrogen-like activities of ginsenoside Rg1 in human breast cancer (MCF-7) cells. Br J Pharmacol 2009;156:1136-1146.
22. Gehm BD, McAndrews JM, Chien PY, Jameson JL. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Natl Acad Sci U S A 1997;94:14138-14143.
23. Chen D, Lucey MJ, Phoenix F, Lopez-Garcia J, Hart SM, Losson R, Buluwela L, Coombes RC, Chambon P, Schar P et al. T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha. J Biol Chem 2003;278:38586-38592.
24. Li X, Huang J, Yi P, Bambara RA, Hilf R, Muyan M. Single-chain estrogen receptors (ERs) reveal that the ERalpha/ beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways. Mol Cell Biol 2004;24:7681-7694.
25. La Rosa P, Acconcia F. Signaling functions of ubiquitin in the 17ß-estradiol (E2):estrogen receptor (ER) a network. J Steroid Biochem Mol Biol 2011;127:223-230.
26. McDevitt MA, Glidewell-Kenney C, Jimenez MA, Ahearn PC, Weiss J, Jameson JL, Levine JE. New insights into the classical and non-classical actions of estrogen: evidence from estrogen receptor knock-out and knock-in mice. Mol Cell Endocrinol 2008;290:24-30.
27. Barros RP, Gustafsson JA. Estrogen receptors and the metabolic network. Cell Metab 2011;14:289-299.
28. Gehm BD, McAndrews JM, Jordan VC, Jameson JL. EGF activates highly selective estrogen-responsive reporter plasmids by an ER-independent pathway. Mol Cell Endocrinol 2000;159:53-62.
29. Cho J, Kim D, Lee S, Lee Y. Cobalt chloride-induced estrogen receptor alpha down-regulation involves hypoxiainducible factor-1alpha in MCF-7 human breast cancer cells. Mol Endocrinol 2005;19:1191-1199.
30. Valley CC, Solodin NM, Powers GL, Ellison SJ, Alarid ET. Temporal variation in estrogen receptor-alpha protein turnover in the presence of estrogen. J Mol Endocrinol 2008;40:23-34.
31. Henley DV, Korach KS. Physiological effects and mechanisms of action of endocrine disrupting chemicals that alter estrogen signaling. Hormones (Athens) 2010;9:191-205.
32. Kim EY, Baek IH, Rhyu MR. Cardioprotective effects of aqueous Schizandra chinensis fruit extract on ovariectomized and balloon-induced carotid artery injury rat models: effects on serum lipid profiles and blood pressure. J Ethnopharmacol 2011;134:668-675.
33. Wangen KE, Duncan AM, Xu X, Kurzer MS. Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. Am J Clin Nutr 2001;73:225-231.
34. Forsythe WA, Green MS, Anderson JJ. Dietary protein effects on cholesterol and lipoprotein concentrations: a review. J Am Coll Nutr 1986;5:533-549.
35. Szkudelska K, Nogowski L. Genistein: a dietary compound inducing hormonal and metabolic changes. J Steroid Biochem Mol Biol 2007;105:37-45.