T cells detect intracellular DNA but fail to induce type I IFN responses: Implications for restriction of HIV replication

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Berg, Randi K ^a   Rahbek, Stine H ^b,c   Kofod Olsen, Emil ^a,b   Holm, Christian K ^b,c   Melchjorsen, Jesper ^a   Jensen, David G ^a   Hansen, Anne Louise ^b   Jørgensen, Louise B ^d   Ostergaard, Lars ^a   Tolstrup, Martin ^a   Larsen, Carsten S ^a   Paludan, Søren R ^b,c   Jakobsen, Martin R ^b,c   Mogensen, Trine H ^a,c  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c Aarhus Research Center for Innate Immunology   (Denmark)

^d STATENS SERUM INSTITUT   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERFERON; INTERFERON INDUCIBLE PROTEIN 16; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 2; STIMULATOR OF INTERFERON GENE; SYNTHETIC DNA; TANK BINDING KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE RESPONSE; CYTOSOL; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; MACROPHAGE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VIRUS REPLICATION;

APOPTOSIS; BIOLOGICAL TRANSPORT; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; CYTOSOL; DNA; HIV INFECTIONS; HIV-1; HUMANS; INFLAMMATION MEDIATORS; INTERFERON TYPE I; INTERLEUKIN-2; LEUKOCYTES, MONONUCLEAR; MEMBRANE PROTEINS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; T-LYMPHOCYTES; TRANSFECTION; VIRUS REPLICATION;

EID: 84896744932     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084513     Document Type: Article

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