Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11

Nature

Volumn 491, Issue 7422, 2012, Pages 125-128

  Li, Manqing ^a   Kao, Elaine ^a   Gao, Xia ^a   Sandig, Hilary ^a   Limmer, Kirsten ^a   Pavon Eternod, Mariana ^b   Jones, Thomas E ^b   Landry, Sebastien ^c   Pan, Tao ^b   Weitzman, Matthew D ^c   David, Michael ^a,d  

^a SECTION OF MOLECULAR BIOLOGY   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; PROTEIN; SLFN11 PROTEIN; UNCLASSIFIED DRUG;

MAMMAL;

ARTICLE; CODON; CONTROLLED STUDY; HUMAN; INNATE IMMUNITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RETROVIRUS INFECTION; REVERSE TRANSCRIPTION; RNA TRANSPORT; VIRUS REPLICATION;

CELL LINE; CELLS, CULTURED; CODON; GENE EXPRESSION REGULATION, VIRAL; HEK293 CELLS; HIV-1; HUMANS; IMMUNITY, INNATE; NUCLEAR PROTEINS; PROTEIN BIOSYNTHESIS; REVERSE TRANSCRIPTION; RNA, TRANSFER; RNA, VIRAL; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY; VIRAL PROTEINS; VIRUS INTEGRATION;

HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMALIA;

EID: 84868377002     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11433     Document Type: Article

References (28)

1. Sohn, W. J. et al. Novel transcriptional regulation of the schlafen-2 gene in macrophages in response to TLR-triggered stimulation. Mol. Immunol. 44, 3273-3282 (2007).
2. Yoneyama, M. et al.Sharedanduniquefunctions of theDExD/H-box helicases RIGI, MDA5, and LGP2 in antiviral innate immunity. J. Immunol. 175, 2851-2858 (2005).
3. Schwarz, D. A., Katayama, C. D. & Hedrick, S. M. Schlafen, a new family of growth regulatory genes that affect thymocytedevelopment. Immunity 9,657-668(1998).
4. Geserick, P., Kaiser, F., Klemm, U., Kaufmann, S. H.&Zerrahn, J.Modulationof T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Int. Immunol. 16, 1535-1548 (2004).
5. Berger, M. et al. An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence. Nature Immunol. 11, 335-343 (2010).
6. Fritz, C. C.& Green, M. R. HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs. Curr. Biol. 6, 848-854 (1996).
7. Fischer, U., Huber, J., Boelens, W. C., Mattaj, I. W. & Luehrmann, R. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82, 475-483 (1995).
8. Malim, M. H., Hauber, J., Le, S. Y., Maizel, J. V. & Cullen, B. R. The HIV-1 rev transactivator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. Nature 338, 254-257 (1989).
9. Van Damme, N. et al. The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. Cell Host Microbe 3, 245-252 (2008).
10. Neil, S. J., Zang, T. & Bieniasz, P. D. Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. Nature 451, 425-430 (2008).
11. Ganser-Pornillos, B. K., Yeager, M. & Sundquist, W. I. The structural biology of HIV assembly. Curr. Opin. Struct. Biol. 18, 203-217 (2008).
12. Coleman, J. R. et al. Virus attenuation by genome-scale changes in codon pair bias. Science 320, 1784-1787 (2008).
13. Zhou, T., Gu, W., Ma, J., Sun, X. & Lu, Z. Analysis of synonymous codon usage in H5N1 virus and other influenza A viruses. Biosystems 81, 77-86 (2005).
14. Meintjes, P. L. & Rodrigo, A. G. Evolution of relative synonymous codon usage in human immunodeficiency virus type-1. J. Bioinform. Comput. Biol. 3, 157-168 (2005).
15. Frelin, L. et al. Codon optimization and mRNA amplification effectively enhances the immunogenicity of the hepatitis C virus nonstructural 3/4A gene. Gene Ther. 11, 522-533 (2004).
16. Forsberg, R.&Christiansen, F. B.A codon-basedmodel of host-specific selection in parasites, with an application to the influenza A virus. Mol. Biol. Evol. 20, 1252-1259 (2003).
17. Plotkin, J. B. & Dushoff, J. Codon bias and frequency-dependent selection on the hemagglutinin epitopes of influenza A virus. Proc. Natl Acad. Sci. USA 100, 7152-7157 (2003).
18. Grantham, P. & Perrin, P. AIDS virus and HTLV-I differ in codon choices. Nature 319, 727-728 (1986).
19. Wong, E. H. M.,Smith, D. K., Rabadan, R., Peiris, M.&Poon, L. L. M.Codonusage bias and the evolution of influenza A viruses. Codon usage biases of influenza virus. BMC Evol. Biol. 10, 253 (2010).
20. van Weringh, A. et al. HIV-1 modulates the tRNA pool to improve translation efficiency. Mol. Biol. Evol. 28, 1827-1834 (2011).
21. Kofman, A. et al. HIV-1 gag expression is quantitatively dependent on the ratio of native and optimized codons. Tsitologiia 45, 86-93 (2003).
22. Haas, J., Park, E. C. & Seed, B. Codon usage limitation in the expression of HIV-1 envelope glycoprotein. Curr. Biol. 6, 315-324 (1996).
23. Berkhout, B. & van Hemert, F. J. The unusual nucleotide content of the HIV RNA genome results in a biased amino acid composition of HIV proteins. Nucleic Acids Res. 22, 1705-1711 (1994).
24. Kypr, J. & Mrazek, J. Unusual codon usage of HIV. Nature 327, 20 (1987).
25. Pavon-Eternod, M. et al. tRNA over-expression in breast cancer and functional consequences. Nucleic Acids Res. 37, 7268-7280 (2009).
26. Dittmar, K. A., Mobley, E. M., Radek, A. J. & Pan, T. Exploring the regulation of tRNA distribution on the genomic scale. J. Mol. Biol. 337, 31-47 (2004).
27. Coccia, E. M., Krust, B. & Hovanessian, A. G. Specific inhibition of viral protein synthesis in HIV-infected cells in response to interferon treatment. J. Biol. Chem. 269, 23087-23094 (1994).
28. Connor, R. I., Chen, B. K., Choe, S. & Landau, N. R. Vpr is required for efficient replication of humanimmunodeficiency virus type-1 inmononuclear phagocytes. Virology 206, 935-944 (1995).