Transition state analogue structures of human phosphoglycerate kinase establish the importance of charge balance in catalysis

Journal of the American Chemical Society

Volumn 132, Issue 18, 2010, Pages 6507-6516

  Cliff, Matthew J ^a   Bowler, Matthew W ^b   Varga, Andrea ^c   Marston, James P ^a   Szabó, Judit ^c   Hounslow, Andrea M ^a   Baxter, Nicola J ^a,d   Blackburn, G Michael ^a   Vas, Mária ^c   Waltho, Jonathan P ^a,d  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM FLUORIDE; CHARGE BALANCES; GROUND-STATE STRUCTURES; HIGH-RESOLUTION STRUCTURES; IN-LINE; METAL FLUORIDE; OCTAHEDRAL GEOMETRY; PHOSPHATE GROUP; PHOSPHOGLYCERATE KINASE; PHOSPHORYL GROUPS; PHOSPHORYL TRANSFER; SIDE CHAINS; TRANSITION STATE; TRANSITION-STATE ANALOGUES;

ENZYMES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SECURITY SYSTEMS;

X RAY CRYSTALLOGRAPHY;

ALPHA PHOSPHATE; ALUMINUM DERIVATIVE; FLUORINE; MAGNESIUM DERIVATIVE; PHOSPHATE; PHOSPHOGLYCERATE KINASE; TETRAFLUOROALUMINATE; TRIFLUOROMAGNESATE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COMPLEX FORMATION; ENZYME STRUCTURE; FLUORINE NUCLEAR MAGNETIC RESONANCE; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY;

ADENOSINE DIPHOSPHATE; ALUMINUM COMPOUNDS; BIOCATALYSIS; BIOPHYSICAL PROCESSES; ELECTRONS; FLUORIDES; GLYCERIC ACIDS; HUMANS; ISOENZYMES; MAGNESIUM; MODELS, MOLECULAR; PHOSPHOGLYCERATE KINASE; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY;

EID: 77952078045     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja100974t     Document Type: Article

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