On the conservation of the slow conformational dynamics within the amino acid kinase family: NAGK the paradigm

PLoS Computational Biology

Volumn 6, Issue 4, 2010, Pages

  Marcos, Enrique ^a   Crehuet, Ramon ^a   Bahar, Ivet ^b  

^a INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYNAMICS; ENZYMES; MARKOV PROCESSES; SIGNAL TRANSDUCTION;

AMINO-ACIDS; CATALYTIC MECHANISMS; CONFORMATIONAL DYNAMICS; KINASE FAMILY; L-GLUTAMATE; MODES OF MOTION; N ACETYLS; NORMAL MODE ANALYSIS; RATE LIMITING; TIME-SCALES;

AMINO ACIDS;

AMINO ACID KINASE; N ACETYLGLUTAMIC ACID KINASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; ACETYLGLUTAMATE KINASE;

ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; MOLECULAR DYNAMICS; MOLECULAR MODEL; PROTEIN FAMILY; SIGNAL TRANSDUCTION; STATISTICAL MODEL; ANISOTROPY; BIOLOGY; CHEMISTRY; ENZYME ACTIVE SITE; METABOLISM; METHODOLOGY; NORMAL DISTRIBUTION; PROBABILITY; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; ANISOTROPY; CATALYTIC DOMAIN; COMPUTATIONAL BIOLOGY; MARKOV CHAINS; MOLECULAR DYNAMICS SIMULATION; NORMAL DISTRIBUTION; PHOSPHOTRANSFERASES (CARBOXYL GROUP ACCEPTOR); SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77954614766     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000738     Document Type: Article

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