A spring-loaded release mechanism regulates domain movement and catalysis in phosphoglycerate kinase

Journal of Biological Chemistry

Volumn 286, Issue 16, 2011, Pages 14040-14048

  Zerrad, Louiza ^a   Merli, Angelo ^b   Schröder, Gunnar F ^c   Varga, Andrea ^d   Gráczer, Éva ^d   Pernot, Petra ^a   Round, Adam ^d   Vas, Mária ^e   Bowler, Matthew W ^a  

^a EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

^b UNIVERSITY OF PARMA   (Italy)

^c FORSCHUNGSZENTRUM JÜLICH   (Germany)

^d INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^e EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DOMAIN MOVEMENT; ELASTIC NETWORKS; HYDROPHOBIC REGIONS; IONIC INTERACTION; ONCOGENESIS; OPEN CONFORMATION; PHOSPHOGLYCERATE KINASE; PRODUCT RELEASE; RAPID DIFFUSION; REACTION CYCLES; RELEASE MECHANISM; RESTING STATE; SHORT PERIODS; SMALL ANGLE X-RAY SCATTERING; SUBSTRATE BINDING; THERMODYNAMICALLY STABLE;

BINDING SITES; BIOCHEMISTRY; CATALYSIS; SCATTERING; SUBSTRATES; X RAY SCATTERING;

ENZYMES;

APOENZYME; PHOSPHOGLYCERATE KINASE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HUMAN; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BIOPHYSICS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PHOSPHOGLYCERATE KINASE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SCATTERING, RADIATION; SEQUENCE HOMOLOGY, AMINO ACID; THERMODYNAMICS;

EID: 79954607450     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.206813     Document Type: Article

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