Changes in dynamics upon oligomerization regulate substrate binding and allostery in amino acid kinase family members

PLoS Computational Biology

Volumn 7, Issue 9, 2011, Pages

  Marcos, Enrique ^a   Crehuet, Ramon ^a   Bahar, Ivet ^b  

^a INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DEGREES OF FREEDOM (MECHANICS); DYNAMICS; ENZYMES; MONOMERS; OLIGOMERIZATION;

ALLOSTERIC REGULATION; ALLOSTERY; AMINO-ACIDS; DYNAMIC FEATURES; FUNCTIONAL REQUIREMENT; INTERFACIAL INTERACTION; KINASE FAMILY; OLIGOMERIZATIONS; PACKING GEOMETRY; SUBSTRATE-BINDING;

OLIGOMERS;

ACETYLGLUTAMATE KINASE; AMINO ACID KINASE; ARGININE; DIMER; ENZYME; MONOMER; OLIGOMER; PROTEIN; UNCLASSIFIED DRUG; URIDINE PHOSPHATE KINASE; AMINO ACID; CARBAMATE KINASE; NUCLEOSIDE MONOPHOSPHATE KINASE; PHOSPHOTRANSFERASE;

ALLOSTERISM; ARTICLE; CONTROLLED STUDY; DYNAMICS; ENZYME SUBSTRATE COMPLEX; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR STABILITY; OLIGOMERIZATION; PROTEIN MULTIMERIZATION; THERMODYNAMICS; BINDING SITE; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; METABOLISM; MOLECULAR DYNAMICS; PROTEIN BINDING; PROTEIN QUATERNARY STRUCTURE;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; AMINO ACIDS; CATALYTIC DOMAIN; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DIMERIZATION; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; NUCLEOSIDE-PHOSPHATE KINASE; PHOSPHOTRANSFERASES; PHOSPHOTRANSFERASES (CARBOXYL GROUP ACCEPTOR); PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 80053446329     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002201     Document Type: Article

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