Characterization of lovastatin-docosahexaenoate anticancer properties against breast cancer cells

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 6, 2014, Pages 1899-1908

  Siddiqui, Rafat A ^a,b   Harvey, Kevin A ^a   Xu, Zhidong ^a   Natarajan, Selvamuthu K ^a   Davisson, V Jo ^c  

^a METHODIST RESEARCH INSTITUTE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

Breast cancer; Docosahexaenoic acid; Lipid drug conjugates; Lovastatin

Indexed keywords

ANTINEOPLASTIC AGENT; DOCOSAHEXAENOIC ACID; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; LOVASTATIN DOCOSAHEXAENOIC ACID CONJUGATE; MEVALONIC ACID; MEVINOLIN; PROTEIN P21; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL STRAIN MDA MB 231; CELL STRAIN MDA MB 468; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SERUM; WESTERN BLOTTING; BREAST NEOPLASMS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DOCOSAHEXAENOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LOVASTATIN; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84896721468     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.01.051     Document Type: Article

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