Statins induce apoptosis in ovarian cancer cells through activation of JNK and enhancement of Bim expression

Cancer Chemotherapy and Pharmacology

Volumn 63, Issue 6, 2009, Pages 997-1005

  Liu, Hongli ^a,c   Liang, Shu Ling ^b   Kumar, Sheetal ^c   Weyman, Crystal M ^c   Liu, Wendy ^d   Zhou, Aimin ^c  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

^c CLEVELAND STATE UNIVERSITY   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Ovarian cancer; Small GTPase; Statin

Indexed keywords

ATORVASTATIN; BIM PROTEIN; GUANOSINE TRIPHOSPHATASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; PROTEIN CDC42; RAC1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CELL GROWTH; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; OVARY CANCER; PRIORITY JOURNAL;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CDC42 GTP-BINDING PROTEIN; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LOVASTATIN; MEMBRANE PROTEINS; OVARIAN NEOPLASMS; PROTO-ONCOGENE PROTEINS; PYRROLES; RAC1 GTP-BINDING PROTEIN;

EID: 63949084962     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0830-7     Document Type: Article

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