Lovastatin inhibits tumor growth and metastasis development of a rat fibrosarcoma

Cancer Biotherapy and Radiopharmaceuticals

Volumn 13, Issue 5, 1998, Pages 387-393

  Matar, Pablo ^a   Rozados, Viviana R ^a   Roggero, Eduardo A ^a   Scharovsky, O Graciela ^a  

^a FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; ISOPRENOID; MEVALONIC ACID; MEVINOLIN; PROTEIN P21; RAS PROTEIN;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL CYCLE; CELL SURVIVAL; CHEMOSENSITIVITY; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; DRUG EFFECT; ENZYME REGULATION; FEMALE; FIBROSARCOMA; HUMAN; LUNG METASTASIS; MALE; METASTASIS INHIBITION; PRIORITY JOURNAL; RAT; TUMOR VOLUME;

EID: 0032408520     PISSN: 10849785     EISSN: None     Source Type: Journal    
DOI: 10.1089/cbr.1998.13.387     Document Type: Article

References (15)

1. Ho YK, Smith RG, Brown MS, and Goldstein JL. Low-density Lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells. Blood 1978;52:1099-114.
2. Siperstein MD, and Fagan VM. Deletion of the cholesterol negative feedback system in liver tumors. Cancer Res 1964;24:1108-115.
3. Chen HW, Kandutsch AA, and Heiniger HJ. The role of cholesterol in malignancy. Prog Exp Tumor Res 1978;22:275-316.
4. Quesney-Hueneeus V, Wiley MH, and Siperstein MD. Essential role for mevalonate synthesis in DNA replication. Proc Natl Acad Sci USA 1979;76:5056-60.
5. Goldstein JL, and Brown MS. Regulation of the mevalonate pathway. Nature (Lond.) 1990;343:425-30.
6. Perez-Sala D, and Mollinedo F. Inhibition of isoprenoid biosynthesis induces apoptosis in human promyelocytic HL-60 cells. Biochem Biophys Res Commun 1994;199:1209-15.
7. Kawata S, Takaishi K, Nagase T, et al. Increase in the active form of 3-hydroxy-3-methylgutaryl coenzyme A reductase in human hepatocellular carcinoma: possible mechanism for alteration of cholesterol biosynthesis. Cancer Res 1990;50:3270-73.
8. Harwood HJ, Alvarez IM, Noyes WD, and Stacpoole PW. In vivo regulation of human leucocyte-3-hydroxy-3-methylgutaryl coenzyme A reductase: increased enzyme protein concentration and catalytic efficiency in human leukemia and lymphoma. J Lipid Res 1992;32:1327-52.
9. Feingold KR, Wiley MH, Moser AH, and Siperstein MD. Altered activation state of 3-hydroxy-3-methylgutaryl coenzyme A reductase in liver tumors. Arch Biochem Biophys 1983;226:231-41.
10. Maltese WA, Defendini R, Green RA, Sheridan KM, and Donley DK. Suppression of murine neuroblastoma growth in vivo by mevilonin a competitive inhibitor of 3-hydroxy-3-methylgutaryl CoA reductase. J Clin Invest 1985;76:1748-54.
11. Tobert JA. Efficacy and long-term adverse effect pattern for Lovastatin. Am J Cardiol 1988;62:28J-34J.
12. Bonfil RD, Reddel RR, Ura H, et al. Invasive and metastatic potential of a v-Ha-ras-transformed human bronchial epithelial cell line. J Natl Cancer Inst 1989;81:587-94.
13. Chambers AF, and Tuck AB. Ras-responsive genes and tumor metastasis. Critical Rev Oncogenesis 1993;4:95-114.
14. Calderari S, Font MT, Garrocq O, et al. The inbred IIM/Fm stock. Rat News Letter 1991;25:28-29.
15. Doménico AD, Rabasa SL, Font MT, Suárez JM. Sarcoma E-100. Ciencia e Investigación 1963;19:462-465.