-
1
-
-
0017252257
-
Classification and relationships of induced chromosomal structural changes
-
Savage JR. Classification and relationships of induced chromosomal structural changes. J Med Genet. 1976;13(2):103-22.
-
(1976)
J Med Genet
, vol.13
, Issue.2
, pp. 103-122
-
-
Savage, J.R.1
-
2
-
-
84864255882
-
The origin and evolution of mutations in acute myeloid leukemia
-
Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, Koboldt DC, et al. The origin and evolution of mutations in acute myeloid leukemia. Cell. 2012;150(2):264-78.
-
(2012)
Cell
, vol.150
, Issue.2
, pp. 264-278
-
-
Welch, J.S.1
Ley, T.J.2
Link, D.C.3
Miller, C.A.4
Larson, D.E.5
Koboldt, D.C.6
-
3
-
-
0034199806
-
The role of oncogenic kinases in human cancer (Review)
-
Tsatsanis C, Spandidos DA. The role of oncogenic kinases in human cancer (Review). Int J Mol Med. 2000;5(6):583-90.
-
(2000)
Int J Mol Med
, vol.5
, Issue.6
, pp. 583-590
-
-
Tsatsanis, C.1
Spandidos, D.A.2
-
4
-
-
0842346437
-
Principles of Tumor Suppression
-
DOI 10.1016/S0092-8674(03)01075-4
-
Sherr CJ. Principles of tumor suppression. Cell. 2004;116(2):235-46. (Pubitemid 38167315)
-
(2004)
Cell
, vol.116
, Issue.2
, pp. 235-246
-
-
Sherr, C.J.1
-
5
-
-
0015694748
-
A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
-
Rowley JD. A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature. 1973;243(5405):290-3.
-
(1973)
Nature
, vol.243
, Issue.5405
, pp. 290-293
-
-
Rowley, J.D.1
-
6
-
-
2542500611
-
The biology of CML blast crisis
-
DOI 10.1182/blood-2003-12-4111
-
Calabretta B, Perrotti D. The biology of CML blast crisis. Blood. 2004;103(11):4010-22. (Pubitemid 38685338)
-
(2004)
Blood
, vol.103
, Issue.11
, pp. 4010-4022
-
-
Calabretta, B.1
Perrotti, D.2
-
7
-
-
0034670036
-
The molecular biology of chronic myeloid leukemia
-
Deininger MW, Goldman JM, Melo JV. The molecular biology of chronic myeloid leukemia. Blood. 2000;96(10):3343-56.
-
(2000)
Blood
, vol.96
, Issue.10
, pp. 3343-3356
-
-
Deininger, M.W.1
Goldman, J.M.2
Melo, J.V.3
-
8
-
-
0022544401
-
The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene
-
Ben-Neriah Y, Daley GQ, Mes-Masson AM, Witte ON, Baltimore D. The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene. Science. 1986;233(4760):212-4. (Pubitemid 16008117)
-
(1986)
Science
, vol.233
, Issue.4760
, pp. 212-214
-
-
Ben-Neriah, Y.1
Daley, G.Q.2
Mes-Masson, A.-M.3
-
9
-
-
0017452393
-
The clinical features of chronic granulocytic leukaemia
-
Spiers AS. The clinical features of chronic granulocytic leukaemia. Clin Haematol. 1977;6(1):77-95.
-
(1977)
Clin Haematol
, vol.6
, Issue.1
, pp. 77-95
-
-
Spiers, A.S.1
-
10
-
-
77954977940
-
Chronic myeloid leukemia: Mechanisms of blastic transformation
-
Perrotti D, Jamieson C, Goldman J, Skorski T. Chronic myeloid leukemia: mechanisms of blastic transformation. J Clin Invest. 2010;120(7):2254-64.
-
(2010)
J Clin Invest
, vol.120
, Issue.7
, pp. 2254-2264
-
-
Perrotti, D.1
Jamieson, C.2
Goldman, J.3
Skorski, T.4
-
11
-
-
84876990097
-
Protein phosphatase 2A: A target for anticancer therapy
-
Perrotti D, Neviani P. Protein phosphatase 2A: a target for anticancer therapy. Lancet Oncol. 2013;14(6):e229-38.
-
(2013)
Lancet Oncol
, vol.14
, Issue.6
-
-
Perrotti, D.1
Neviani, P.2
-
12
-
-
80755159112
-
Chronic myeloid leukemia: Mechanisms of resistance and treatment
-
v
-
Jabbour E, Parikh SA, Kantarjian H, Cortes J. Chronic myeloid leukemia: mechanisms of resistance and treatment. Hematol Oncol Clin North Am. 2011;25(5):981-95. v.
-
(2011)
Hematol Oncol Clin North Am
, vol.25
, Issue.5
, pp. 981-995
-
-
Jabbour, E.1
Parikh, S.A.2
Kantarjian, H.3
Cortes, J.4
-
13
-
-
84878843475
-
Mechanisms of resistance to BCR-ABL and other kinase inhibitors
-
Lamontanara AJ, Gencer EB, Kuzyk O, Hantschel O. Mechanisms of resistance to BCR-ABL and other kinase inhibitors. Biochim Biophys Acta. 2013;1834(7):1449-59.
-
(2013)
Biochim Biophys Acta
, vol.1834
, Issue.7
, pp. 1449-1459
-
-
Lamontanara, A.J.1
Gencer, E.B.2
Kuzyk, O.3
Hantschel, O.4
-
14
-
-
84887991063
-
A critical review of trials of first-line BCR-ABL inhibitor treatment in patients with newly diagnosed chronic myeloid leukemia in chronic phase
-
Jabbour E, Lipton JH. A critical review of trials of first-line BCR-ABL inhibitor treatment in patients with newly diagnosed chronic myeloid leukemia in chronic phase. Clinical Lymphoma Myeloma Leuk. 2013;13(6):646-56.
-
(2013)
Clinical Lymphoma Myeloma Leuk
, vol.13
, Issue.6
, pp. 646-656
-
-
Jabbour, E.1
Lipton, J.H.2
-
15
-
-
84864446464
-
How I, treat CML blast crisis
-
Hehlmann R. How I, treat CML blast crisis. Blood. 2012;120(4):737-47.
-
(2012)
Blood
, vol.120
, Issue.4
, pp. 737-747
-
-
Hehlmann, R.1
-
16
-
-
79955018499
-
Tolerability-adapted imatinib 800 mg/d versus 400 mg/d versus 400 mg/d plus interferon-alpha in newly diagnosed chronic myeloid leukemia
-
Hehlmann R, Lauseker M, Jung-Munkwitz S, Leitner A, Muller MC, Pletsch N, et al. Tolerability-adapted imatinib 800 mg/d versus 400 mg/d versus 400 mg/d plus interferon-alpha in newly diagnosed chronic myeloid leukemia. J Clin Oncol. 2011;29(12):1634-42.
-
(2011)
J Clin Oncol
, vol.29
, Issue.12
, pp. 1634-1642
-
-
Hehlmann, R.1
Lauseker, M.2
Jung-Munkwitz, S.3
Leitner, A.4
Muller, M.C.5
Pletsch, N.6
-
17
-
-
3943088431
-
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
-
DOI 10.1056/NEJMoa040258
-
Jamieson CH, Ailles LE, Dylla SJ, Muijtjens M, Jones C, Zehnder JL, et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl JMed. 2004;351(7):657-67. (Pubitemid 39063268)
-
(2004)
New England Journal of Medicine
, vol.351
, Issue.7
, pp. 657-667
-
-
Jamieson, C.H.M.1
Ailles, L.E.2
Dylla, S.J.3
Muijtjens, M.4
Jones, C.5
Zehnder, J.L.6
Gotlib, J.7
Li, K.8
Manz, M.G.9
Keating, A.10
Sawyers, C.L.11
Weissman, I.L.12
-
18
-
-
37249003928
-
Oncogene addiction: Setting the stage for molecularly targeted cancer therapy
-
DOI 10.1101/gad.1609907
-
Sharma SV, Settleman J. Oncogene addiction: setting the stage for molecularly targeted cancer therapy. Genes Dev. 2007;21(24):3214-31. (Pubitemid 350277749)
-
(2007)
Genes and Development
, vol.21
, Issue.24
, pp. 3214-3231
-
-
Sharma, S.V.1
Settleman, J.2
-
19
-
-
84874285950
-
Targeting chronic myeloid leukemia stem cells
-
Kinstrie R, Copland M. Targeting chronic myeloid leukemia stem cells. Curr Hematol Malig Rep. 2013;8(1):14-21.
-
(2013)
Curr Hematol Malig Rep
, vol.8
, Issue.1
, pp. 14-21
-
-
Kinstrie, R.1
Copland, M.2
-
21
-
-
84860829034
-
Genomic instability in chronic myeloid leukemia: Targets for therapy?
-
Muvarak N, Nagaria P, Rassool FV. Genomic instability in chronic myeloid leukemia: targets for therapy? Curr Hematol Malig Rep. 2012;7(2):94-102.
-
(2012)
Curr Hematol Malig Rep
, vol.7
, Issue.2
, pp. 94-102
-
-
Muvarak, N.1
Nagaria, P.2
Rassool, F.V.3
-
22
-
-
0027207728
-
Genetic alterations in the p53 gene in the blast crisis of chronic myelogeneous leukemia: Analysis by polymerase chain reaction based techniques
-
Neubauer A, He M, Schmidt CA, Huhn D, Liu ET. Genetic alterations in the p53 gene in the blast crisis of chronic myelogenous leukemia: analysis by polymerase chain reaction based techniques. Leukemia. 1993;7(4):593-600. (Pubitemid 23139864)
-
(1993)
Leukemia
, vol.7
, Issue.4
, pp. 593-600
-
-
Neubauer, A.1
He, M.2
Schmidt, C.A.3
Huhn, D.4
Liu, E.T.5
-
23
-
-
80051573352
-
BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: Recommendations from an expert panel on behalf of European LeukemiaNet
-
Soverini S, Hochhaus A, Nicolini FE, Gruber F, Lange T, Saglio G, et al. BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet. Blood. 2011;118(5):1208-15.
-
(2011)
Blood
, vol.118
, Issue.5
, pp. 1208-1215
-
-
Soverini, S.1
Hochhaus, A.2
Nicolini, F.E.3
Gruber, F.4
Lange, T.5
Saglio, G.6
-
24
-
-
68549125516
-
The INK4-ARF (CDKN2A/B) locus in hematopoiesis and BCR-ABL-induced leukemias
-
Williams RT, Sherr CJ. The INK4-ARF (CDKN2A/B) locus in hematopoiesis and BCR-ABL-induced leukemias. Cold Spring Harb Symp Quant Biol. 2008;73:461-7.
-
(2008)
Cold Spring Harb Symp Quant Biol
, vol.73
, pp. 461-467
-
-
Williams, R.T.1
Sherr, C.J.2
-
25
-
-
44849129491
-
Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL
-
DOI 10.1101/gad.1673908
-
Mullighan CG, Williams RT, Downing JR, Sherr CJ. Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL. Genes Dev. 2008;22(11):1411-5. (Pubitemid 351793074)
-
(2008)
Genes and Development
, vol.22
, Issue.11
, pp. 1411-1415
-
-
Mullighan, C.G.1
Williams, R.T.2
Downing, J.R.3
Sherr, C.J.4
-
26
-
-
79952451556
-
A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases
-
Grossmann V, Kohlmann A, Zenger M, Schindela S, Eder C, Weissmann S, et al. A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases. Leukemia. 2011;25(3):557-60.
-
(2011)
Leukemia
, vol.25
, Issue.3
, pp. 557-560
-
-
Grossmann, V.1
Kohlmann, A.2
Zenger, M.3
Schindela, S.4
Eder, C.5
Weissmann, S.6
-
27
-
-
73949129831
-
AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms
-
Ding Y, Harada Y, Imagawa J, Kimura A, Harada H. AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms. Blood. 2009;114(25):5201-5.
-
(2009)
Blood
, vol.114
, Issue.25
, pp. 5201-5205
-
-
Ding, Y.1
Harada, Y.2
Imagawa, J.3
Kimura, A.4
Harada, H.5
-
28
-
-
43549086237
-
RUNX1 DNA-binding mutations and RUNX1-PRDM16 cryptic fusions in BCR-ABL+leukemias are frequently associated with secondary trisomy 21 and may contribute to clonal evolution and imatinib resistance
-
Roche-Lestienne C, Deluche L, Corm S, Tigaud I, Joha S, Philippe N, et al. RUNX1 DNA-binding mutations and RUNX1-PRDM16 cryptic fusions in BCR-ABL+leukemias are frequently associated with secondary trisomy 21 and may contribute to clonal evolution and imatinib resistance. Blood. 2008;111(7):3735-41.
-
(2008)
Blood
, vol.111
, Issue.7
, pp. 3735-3741
-
-
Roche-Lestienne, C.1
Deluche, L.2
Corm, S.3
Tigaud, I.4
Joha, S.5
Philippe, N.6
-
29
-
-
84863356975
-
Functional features of RUNX1 mutants in acute transformation of chronic myeloid leukemia and their contribution to inducing murine full-blown leukemia
-
Zhao LJ, Wang YY, Li G, Ma LY, Xiong SM, Weng XQ, et al. Functional features of RUNX1 mutants in acute transformation of chronic myeloid leukemia and their contribution to inducing murine full-blown leukemia. Blood. 2012;119(12):2873-82.
-
(2012)
Blood
, vol.119
, Issue.12
, pp. 2873-2882
-
-
Zhao, L.J.1
Wang, Y.Y.2
Li, G.3
Ma, L.Y.4
Xiong, S.M.5
Weng, X.Q.6
-
30
-
-
84884743586
-
Functionally deregulated AML1/RUNX1 cooperates with BCR-ABL to induce a blastic phase-like phenotype of chronic myelogenous leukemia in mice
-
Yamamoto K, Tsuzuki S, Minami Y, Yamamoto Y, Abe A, Ohshima K, et al. Functionally deregulated AML1/RUNX1 cooperates with BCR-ABL to induce a blastic phase-like phenotype of chronic myelogenous leukemia in mice. PloS One. 2013;8(9):e74864.
-
(2013)
PloS One
, vol.8
, Issue.9
-
-
Yamamoto, K.1
Tsuzuki, S.2
Minami, Y.3
Yamamoto, Y.4
Abe, A.5
Ohshima, K.6
-
31
-
-
0028069226
-
Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia
-
Mitani K, Ogawa S, Tanaka T, Miyoshi H, Kurokawa M, Mano H, et al. Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. EMBO J. 1994;13(3):504-10.
-
(1994)
EMBO J
, vol.13
, Issue.3
, pp. 504-510
-
-
Mitani, K.1
Ogawa, S.2
Tanaka, T.3
Miyoshi, H.4
Kurokawa, M.5
Mano, H.6
-
32
-
-
0029091464
-
The AML1/Evi-1 fusion protein in the t(3;21) translocation exhibits transforming activity on Rat1 fibroblasts with dependence on the Evi-1 sequence
-
Kurokawa M, Ogawa S, Tanaka T, Mitani K, Yazaki Y, Witte ON, et al. The AML1/Evi-1 fusion protein in the t(3;21) translocation exhibits transforming activity on Rat1 fibroblasts with dependence on the Evi-1 sequence. Oncogene. 1995;11(5):833-40.
-
(1995)
Oncogene
, vol.11
, Issue.5
, pp. 833-840
-
-
Kurokawa, M.1
Ogawa, S.2
Tanaka, T.3
Mitani, K.4
Yazaki, Y.5
Witte, O.N.6
-
33
-
-
33646075159
-
t(3;21)(q26;q22) in myeloid leukemia: An aggressive syndrome of blast transformation associated with hydroxyurea or antimetabolite therapy
-
Yin CC, Cortes J, Barkoh B, Hayes K, Kantarjian H, Jones D. t(3;21)(q26;q22) in myeloid leukemia: an aggressive syndrome of blast transformation associated with hydroxyurea or antimetabolite therapy. Cancer. 2006;106(8):1730-8.
-
(2006)
Cancer
, vol.106
, Issue.8
, pp. 1730-1738
-
-
Yin, C.C.1
Cortes, J.2
Barkoh, B.3
Hayes, K.4
Kantarjian, H.5
Jones, D.6
-
34
-
-
0031450875
-
The EVI1 gene in myeloid leukemia
-
Nucifora G. The EVI1 gene in myeloid leukemia. Leukemia. 1997;11(12):2022-31. (Pubitemid 28043684)
-
(1997)
Leukemia
, vol.11
, Issue.12
, pp. 2022-2031
-
-
Nucifora, G.1
-
35
-
-
84862908988
-
Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity
-
Kataoka K, Sato T, Yoshimi A, Goyama S, Tsuruta T, Kobayashi H, et al. Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity. J Exp Med. 2011;208(12):2403-16.
-
(2011)
J Exp Med
, vol.208
, Issue.12
, pp. 2403-2416
-
-
Kataoka, K.1
Sato, T.2
Yoshimi, A.3
Goyama, S.4
Tsuruta, T.5
Kobayashi, H.6
-
36
-
-
60549106713
-
EVI1 Impairs myelopoiesis by deregulation of PU.1 function
-
Laricchia-Robbio L, Premanand K, Rinaldi CR, Nucifora G. EVI1 Impairs myelopoiesis by deregulation of PU.1 function. Cancer Res. 2009;69(4):1633-42.
-
(2009)
Cancer Res
, vol.69
, Issue.4
, pp. 1633-1642
-
-
Laricchia-Robbio, L.1
Premanand, K.2
Rinaldi, C.R.3
Nucifora, G.4
-
37
-
-
80054777860
-
Frequent EVI1 translocations in myeloid blast crisis CML that evolves through tyrosine kinase inhibitors
-
Paquette RL, Nicoll J, Chalukya M, Elashoff D, Shah NP, Sawyers C, et al. Frequent EVI1 translocations in myeloid blast crisis CML that evolves through tyrosine kinase inhibitors. Cancer Genet. 2011;204(7):392-7.
-
(2011)
Cancer Genet
, vol.204
, Issue.7
, pp. 392-397
-
-
Paquette, R.L.1
Nicoll, J.2
Chalukya, M.3
Elashoff, D.4
Shah, N.P.5
Sawyers, C.6
-
38
-
-
77955246190
-
Cytogenetic and molecular characterization of double inversion 3 associated with a cryptic BCR-ABL1 rearrangement and additional genetic changes
-
Toydemir R, Rowe L, Hibbard M, Salama M, Shetty S. Cytogenetic and molecular characterization of double inversion 3 associated with a cryptic BCR-ABL1 rearrangement and additional genetic changes. Cancer Genet Cytogenet. 2010;201(2):81-7.
-
(2010)
Cancer Genet Cytogenet
, vol.201
, Issue.2
, pp. 81-87
-
-
Toydemir, R.1
Rowe, L.2
Hibbard, M.3
Salama, M.4
Shetty, S.5
-
39
-
-
48249114377
-
EVI1 activation in blast crisis CML due to juxtaposition to the rare 17q22 partner region as part of a 4-way variant translocation t(9;22)
-
De Weer A, Poppe B, Cauwelier B, Carlier A, Dierick J, Verhasselt B, et al. EVI1 activation in blast crisis CML due to juxtaposition to the rare 17q22 partner region as part of a 4-way variant translocation t(9;22). BMC Cancer. 2008;8:193.
-
(2008)
BMC Cancer
, vol.8
, pp. 193
-
-
De Weer, A.1
Poppe, B.2
Cauwelier, B.3
Carlier, A.4
Dierick, J.5
Verhasselt, B.6
-
40
-
-
84865006559
-
CML cells expressing the TEL/MDS1/EVI1 fusion are resistant to imatinib-induced apoptosis through inhibition of BAD, but are resensitized with ABT-737
-
e2
-
Shimada K, Tomita A, Minami Y, Abe A, Hind CK, Kiyoi H, et al. CML cells expressing the TEL/MDS1/EVI1 fusion are resistant to imatinib-induced apoptosis through inhibition of BAD, but are resensitized with ABT-737. Exp Hematol. 2012;40(9):724-37. e2.
-
(2012)
Exp Hematol
, vol.40
, Issue.9
, pp. 724-737
-
-
Shimada, K.1
Tomita, A.2
Minami, Y.3
Abe, A.4
Hind, C.K.5
Kiyoi, H.6
-
41
-
-
84861702964
-
Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms
-
Brecqueville M, Rey J, Bertucci F, Coppin E, Finetti P, Carbuccia N, et al. Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms. Genes Chromosomes Cancer. 2012;51(8):743-55.
-
(2012)
Genes Chromosomes Cancer
, vol.51
, Issue.8
, pp. 743-755
-
-
Brecqueville, M.1
Rey, J.2
Bertucci, F.3
Coppin, E.4
Finetti, P.5
Carbuccia, N.6
-
42
-
-
79957593717
-
CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia
-
Makishima H, Jankowska AM, McDevitt MA, O'Keefe C, Dujardin S, Cazzolli H, et al. CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia. Blood. 2011;117(21):e198-206.
-
(2011)
Blood
, vol.117
, Issue.21
-
-
Makishima, H.1
Jankowska, A.M.2
McDevitt, M.A.3
O'Keefe, C.4
Dujardin, S.5
Cazzolli, H.6
-
43
-
-
80053948896
-
Decreased TET2 gene expression during chronic myeloid leukemia progression
-
Albano F, Anelli L, Zagaria A, Coccaro N, Minervini A, Rossi AR, et al. Decreased TET2 gene expression during chronic myeloid leukemia progression. Leuk Res. 2011;35(11):e220-2.
-
(2011)
Leuk Res
, vol.35
, Issue.11
-
-
Albano, F.1
Anelli, L.2
Zagaria, A.3
Coccaro, N.4
Minervini, A.5
Rossi, A.R.6
-
44
-
-
76549109434
-
Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias
-
Abdel-Wahab O, Manshouri T, Patel J, Harris K, Yao J, Hedvat C, et al. Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias. Cancer Res. 2010;70(2):447-52.
-
(2010)
Cancer Res
, vol.70
, Issue.2
, pp. 447-452
-
-
Abdel-Wahab, O.1
Manshouri, T.2
Patel, J.3
Harris, K.4
Yao, J.5
Hedvat, C.6
-
45
-
-
0036090290
-
Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion
-
Thorsteinsdottir U, Mamo A, Kroon E, Jerome L, Bijl J, Lawrence HJ, et al. Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion. Blood. 2002;99(1):121-9.
-
(2002)
Blood
, vol.99
, Issue.1
, pp. 121-129
-
-
Thorsteinsdottir, U.1
Mamo, A.2
Kroon, E.3
Jerome, L.4
Bijl, J.5
Lawrence, H.J.6
-
46
-
-
84865152223
-
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
-
Abdel-Wahab O, Adli M, LaFave LM, Gao J, Hricik T, Shih AH, et al. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell. 2012;22(2):180-93.
-
(2012)
Cancer Cell
, vol.22
, Issue.2
, pp. 180-193
-
-
Abdel-Wahab, O.1
Adli, M.2
LaFave, L.M.3
Gao, J.4
Hricik, T.5
Shih, A.H.6
-
47
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 2010;18(6):553-67.
-
(2010)
Cancer Cell
, vol.18
, Issue.6
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
Ward, P.S.4
Patel, J.5
Shih, A.6
-
48
-
-
79960064353
-
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
-
Moran-Crusio K, Reavie L, Shih A, Abdel-Wahab O, Ndiaye-Lobry D, Lobry C, et al. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell. 2011;20(1):11-24.
-
(2011)
Cancer Cell
, vol.20
, Issue.1
, pp. 11-24
-
-
Moran-Crusio, K.1
Reavie, L.2
Shih, A.3
Abdel-Wahab, O.4
Ndiaye-Lobry, D.5
Lobry, C.6
-
49
-
-
43049139905
-
BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
-
DOI 10.1038/nature06866, PII NATURE06866
-
Mullighan CG, Miller CB, Radtke I, Phillips LA, Dalton J, Ma J, et al. BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature. 2008;453(7191):110-4. (Pubitemid 351630327)
-
(2008)
Nature
, vol.453
, Issue.7191
, pp. 110-114
-
-
Mullighan, C.G.1
Miller, C.B.2
Radtke, I.3
Phillips, L.A.4
Dalton, J.5
Ma, J.6
White, D.7
Hughes, T.P.8
Le, B.M.M.9
Pui, C.-H.10
Relling, M.V.11
Shurtleff, S.A.12
Downing, J.R.13
-
50
-
-
0033566987
-
Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia
-
Nakayama H, Ishimaru F, Avitahl N, Sezaki N, Fujii N, Nakase K, et al. Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia. Cancer Res. 1999;59(16):3931-4. (Pubitemid 29393556)
-
(1999)
Cancer Research
, vol.59
, Issue.16
, pp. 3931-3934
-
-
Nakayama, H.1
Ishimaru, F.2
Avitahl, N.3
Sezaki, N.4
Fujii, N.5
Nakase, K.6
Ninomiya, Y.7
Harashima, A.8
Minowada, J.9
Tsuchiyama, J.10
Imajoh, K.11
Tsubota, T.12
Fukuda, S.13
Sezaki, T.14
Kojima, K.15
Hara, M.16
Takimoto, H.17
Yorimitsu, S.18
Takahashi, I.19
Miyata, A.20
Taniguchi, S.21
Tokunaga, Y.22
Gondo, H.23
Niho, Y.24
Nakao, S.25
Kyo, T.26
Dohy, H.27
Kamada, N.28
Harada, M.29
more..
-
51
-
-
0030933151
-
The role of the Ikaros gene in lymphocyte development and homeostasis
-
DOI 10.1146/annurev.immunol.15.1.155
-
Georgopoulos K, Winandy S, Avitahl N. The role of the Ikaros gene in lymphocyte development and homeostasis. Annu Rev Immunol. 1997;15:155-76. (Pubitemid 27169278)
-
(1997)
Annual Review of Immunology
, vol.15
, pp. 155-176
-
-
Georgopoulos, K.1
Winandy, S.2
Avitahl, N.3
-
52
-
-
84455163100
-
IKAROS isoform 6 enhances BCR-ABL1-mediated proliferation of human CD34+ hematopoietic cells on stromal cells
-
Suzuki K, Ono R, Ohishi K, Masuya M, Kataoka I, Liu B, et al. IKAROS isoform 6 enhances BCR-ABL1-mediated proliferation of human CD34+ hematopoietic cells on stromal cells. Int J Oncol. 2012;40(1):53-62.
-
(2012)
Int J Oncol
, vol.40
, Issue.1
, pp. 53-62
-
-
Suzuki, K.1
Ono, R.2
Ohishi, K.3
Masuya, M.4
Kataoka, I.5
Liu, B.6
-
53
-
-
84862793210
-
Sequential array comparative genomic hybridization analysis identifies copy number changes during blastic transformation of chronic myeloid leukemia
-
Lee ST, Ji Y, Kim HJ, Ki CS, Jung CW, Kim JW, et al. Sequential array comparative genomic hybridization analysis identifies copy number changes during blastic transformation of chronic myeloid leukemia. Leuk Res. 2012;36(4):418-21.
-
(2012)
Leuk Res
, vol.36
, Issue.4
, pp. 418-421
-
-
Lee, S.T.1
Ji, Y.2
Kim, H.J.3
Ki, C.S.4
Jung, C.W.5
Kim, J.W.6
-
54
-
-
76949088438
-
Deletions of immunoglobulin heavy chain and T cell receptor gene regions are uniquely associated with lymphoid blast transformation of chronic myeloid leukemia
-
Nacheva EP, Brazma D, Virgili A, Howard-Reeves J, Chanalaris A, Gancheva K, et al. Deletions of immunoglobulin heavy chain and T cell receptor gene regions are uniquely associated with lymphoid blast transformation of chronic myeloid leukemia. BMC Genomics. 2010;11:41.
-
(2010)
BMC Genomics
, vol.11
, pp. 41
-
-
Nacheva, E.P.1
Brazma, D.2
Virgili, A.3
Howard-Reeves, J.4
Chanalaris, A.5
Gancheva, K.6
-
55
-
-
84887320453
-
The MLL recombinome of acute leukemias in 2013
-
Meyer C, Hofmann J, Burmeister T, Groger D, Park TS, Emerenciano M, et al. The MLL recombinome of acute leukemias in 2013. Leukemia. 2013;27(11):2165-76.
-
(2013)
Leukemia
, vol.27
, Issue.11
, pp. 2165-2176
-
-
Meyer, C.1
Hofmann, J.2
Burmeister, T.3
Groger, D.4
Park, T.S.5
Emerenciano, M.6
-
56
-
-
84873571369
-
Transcriptional suppression of BACH2 by the Bcr-Abl oncoprotein ismediated by PAX5
-
Casolari DA, Makri M, Yoshida C, Muto A, Igarashi K, Melo JV. Transcriptional suppression of BACH2 by the Bcr-Abl oncoprotein ismediated by PAX5. Leukemia. 2013;27(2):409-15.
-
(2013)
Leukemia
, vol.27
, Issue.2
, pp. 409-415
-
-
Casolari, D.A.1
Makri, M.2
Yoshida, C.3
Muto, A.4
Igarashi, K.5
Melo, J.V.6
-
57
-
-
41149169150
-
Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia
-
DOI 10.1073/pnas.0711824105
-
Zhang SJ, Ma LY, Huang QH, Li G, Gu BW, Gao XD, et al. Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia. Proc Natl Acad Sci U S A. 2008;105(6):2076-81. (Pubitemid 351439467)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.6
, pp. 2076-2081
-
-
Zhang, S.-J.1
Ma, L.-Y.2
Huang, Q.-H.3
Li, G.4
Gu, B.-W.5
Gao, X.-D.6
Shi, J.-Y.7
Wang, Y.-Y.8
Gao, L.9
Cai, X.10
Ren, R.-B.11
Zhu, J.12
Chen, Z.13
Chen, S.-J.14
-
58
-
-
67349119504
-
GATA-2 L359 V mutation is exclusively associated with CML progression but not other hematological malignancies and GATA-2 P250A is a novel single nucleotide polymorphism
-
Zhang SJ, Shi JY, Li JY. GATA-2 L359 V mutation is exclusively associated with CML progression but not other hematological malignancies and GATA-2 P250A is a novel single nucleotide polymorphism. Leuk Res. 2009;33(8):1141-3.
-
(2009)
Leuk Res
, vol.33
, Issue.8
, pp. 1141-1143
-
-
Zhang, S.J.1
Shi, J.Y.2
Li, J.Y.3
-
59
-
-
84867979681
-
A new dic(7;12)(p12.21;p12.2) and i(12)(q10) during the lymphoid blast crisis of patient with Ph+chronic myeloid leukemia
-
de Oliveira FM, de Carvalho PL, Falcao RP, Simoes BP. A new dic(7;12)(p12.21;p12.2) and i(12)(q10) during the lymphoid blast crisis of patient with Ph+chronic myeloid leukemia. Med Oncol. 2012;29(4):2332-6.
-
(2012)
Med Oncol
, vol.29
, Issue.4
, pp. 2332-2336
-
-
De Oliveira, F.M.1
De Carvalho, P.L.2
Falcao, R.P.3
Simoes, B.P.4
-
60
-
-
84871584791
-
A novel cytogenetic abnormality t(7;8)(p11.2:Q11.2) and a four-way Philadelphia translocation in an imatinib mesylate-resistant chronic myeloid leukemia patient
-
Al-Achkar W, Aljapawe A, Almedani S, Liehr T, Wafa A. A novel cytogenetic abnormality t(7;8)(p11.2:q11.2) and a four-way Philadelphia translocation in an imatinib mesylate-resistant chronic myeloid leukemia patient. Oncol Lett. 2013;5(2):617-20.
-
(2013)
Oncol Lett
, vol.5
, Issue.2
, pp. 617-620
-
-
Al-Achkar, W.1
Aljapawe, A.2
Almedani, S.3
Liehr, T.4
Wafa, A.5
-
61
-
-
77955758077
-
BCR translocation to derivative chromosome 2: A newcase of chronic myeloid leukemia with a complex variant translocation and Philadelphia chromosome
-
Al-Achkar W, Wafa A, Almedani S. BCR translocation to derivative chromosome 2: a newcase of chronic myeloid leukemia with a complex variant translocation and Philadelphia chromosome. Oncol Lett. 2010;1(3):445-7.
-
(2010)
Oncol Lett
, vol.1
, Issue.3
, pp. 445-447
-
-
Al-Achkar, W.1
Wafa, A.2
Almedani, S.3
-
62
-
-
84860242022
-
Analysis of altered proteins related to blast crisis in chronic myeloid leukemia by proteomic study
-
Zhang J, Jin Z, Du Q, Li R, Yao F, Huang B, et al. Analysis of altered proteins related to blast crisis in chronic myeloid leukemia by proteomic study. Int J Lab Hematol. 2012;34(3):267-73.
-
(2012)
Int J Lab Hematol
, vol.34
, Issue.3
, pp. 267-273
-
-
Zhang, J.1
Jin, Z.2
Du, Q.3
Li, R.4
Yao, F.5
Huang, B.6
-
63
-
-
33644755496
-
AMAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation
-
DOI 10.1182/blood-2005-09-3732
-
Notari M, Neviani P, Santhanam R, Blaser BW, Chang JS, Galietta A, et al. A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation. Blood. 2006;107(6):2507-16. (Pubitemid 43345575)
-
(2006)
Blood
, vol.107
, Issue.6
, pp. 2507-2516
-
-
Notari, M.1
Neviani, P.2
Santhanam, R.3
Blaser, B.W.4
Chang, J.-S.5
Galietta, A.6
Willis, A.E.7
Roy, D.C.8
Caligiuri, M.A.9
Marcucci, G.10
Perrotti, D.11
-
65
-
-
69249092973
-
Proteasome inhibition causes regression of leukemia and abrogates BCR-ABL-induced evasion of apoptosis in part through regulation of forkhead tumor suppressors
-
Jagani Z, Song K, Kutok JL, Dewar MR, Melet A, Santos T, et al. Proteasome inhibition causes regression of leukemia and abrogates BCR-ABL-induced evasion of apoptosis in part through regulation of forkhead tumor suppressors. Cancer Res. 2009;69(16):6546-55.
-
(2009)
Cancer Res
, vol.69
, Issue.16
, pp. 6546-6555
-
-
Jagani, Z.1
Song, K.2
Kutok, J.L.3
Dewar, M.R.4
Melet, A.5
Santos, T.6
-
66
-
-
84867881861
-
Reverse phase protein array profiling reveals distinct proteomic signatures associated with chronic myeloid leukemia progression and with chronic phase in the CD34-positive compartment
-
Quintas-Cardama A, Qiu YH, Post SM, Zhang Y, Creighton CJ, Cortes J, et al. Reverse phase protein array profiling reveals distinct proteomic signatures associated with chronic myeloid leukemia progression and with chronic phase in the CD34-positive compartment. Cancer. 2012;118(21):5283-92.
-
(2012)
Cancer
, vol.118
, Issue.21
, pp. 5283-5292
-
-
Quintas-Cardama, A.1
Qiu, Y.H.2
Post, S.M.3
Zhang, Y.4
Creighton, C.J.5
Cortes, J.6
-
67
-
-
84884560027
-
MicroRNA-150 expression induces myeloid differentiation of human acute leukemia cells and normal hematopoietic progenitors
-
Morris VA, Zhang A, Yang T, Stirewalt DL, Ramamurthy R, Meshinchi S, et al. MicroRNA-150 expression induces myeloid differentiation of human acute leukemia cells and normal hematopoietic progenitors. PloS One. 2013;8(9):e75815.
-
(2013)
PloS One
, vol.8
, Issue.9
-
-
Morris, V.A.1
Zhang, A.2
Yang, T.3
Stirewalt, D.L.4
Ramamurthy, R.5
Meshinchi, S.6
-
68
-
-
77649133970
-
miR-328 functions as an RNA decoy tomodulate hnRNP E2 regulation of mRNA translation in leukemic blasts
-
Eiring AM, Harb JG, Neviani P, Garton C, Oaks JJ, Spizzo R, et al. miR-328 functions as an RNA decoy tomodulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell. 2010;140(5):652-65.
-
(2010)
Cell
, vol.140
, Issue.5
, pp. 652-665
-
-
Eiring, A.M.1
Harb, J.G.2
Neviani, P.3
Garton, C.4
Oaks, J.J.5
Spizzo, R.6
-
70
-
-
84878270797
-
MR-1 blocks the megakaryocytic differentiation and transition of CML from chronic phase to blast crisis through MEK dephosphorylation
-
Zhao W, He H, Ren K, Li B, Zhang H, Lin Y, et al. MR-1 blocks the megakaryocytic differentiation and transition of CML from chronic phase to blast crisis through MEK dephosphorylation. Blood Cancer J. 2013;3:e107.
-
(2013)
Blood Cancer J
, vol.3
-
-
Zhao, W.1
He, H.2
Ren, K.3
Li, B.4
Zhang, H.5
Lin, Y.6
-
71
-
-
84862259765
-
Knock-down of Kaiso induces proliferation and blocks granulocytic differentiation in blast crisis of chronic myeloid leukemia
-
Cofre J, Menezes JR, Pizzatti L, Abdelhay E. Knock-down of Kaiso induces proliferation and blocks granulocytic differentiation in blast crisis of chronic myeloid leukemia. Cancer Cell Int. 2012;12(1):28.
-
(2012)
Cancer Cell Int
, vol.12
, Issue.1
, pp. 28
-
-
Cofre, J.1
Menezes, J.R.2
Pizzatti, L.3
Abdelhay, E.4
-
72
-
-
84867156094
-
Biological effects of decreasing RBM15 on chronic myelogenous leukemia cells
-
Yang Y, Wang S, Zhang Y, Zhu X. Biological effects of decreasing RBM15 on chronic myelogenous leukemia cells. Leuk Lymphoma. 2012;53(11):2237-44.
-
(2012)
Leuk Lymphoma
, vol.53
, Issue.11
, pp. 2237-2244
-
-
Yang, Y.1
Wang, S.2
Zhang, Y.3
Zhu, X.4
-
73
-
-
84885591977
-
Bcl-xL anti-apoptotic network is dispensable for development and maintenance of CML but is required for disease progression where it represents a new therapeutic target
-
Harb JG, Neviani P, Chyla BJ, Ellis JJ, Ferenchak GJ, Oaks JJ, et al. Bcl-xL anti-apoptotic network is dispensable for development and maintenance of CML but is required for disease progression where it represents a new therapeutic target. Leukemia. 2013;27(10):1996-2005.
-
(2013)
Leukemia
, vol.27
, Issue.10
, pp. 1996-2005
-
-
Harb, J.G.1
Neviani, P.2
Chyla, B.J.3
Ellis, J.J.4
Ferenchak, G.J.5
Oaks, J.J.6
-
74
-
-
84876832386
-
Diverse mechanisms of mTOR activation in chronic and blastic phase of chronic myelogenous leukemia
-
Stoklosa T, Glodkowska-Mrowka E, Hoser G, Kielak M, Seferynska I, Wlodarski P. Diverse mechanisms of mTOR activation in chronic and blastic phase of chronic myelogenous leukemia. Exp Hematol. 2013;41(5):462-9.
-
(2013)
Exp Hematol
, vol.41
, Issue.5
, pp. 462-469
-
-
Stoklosa, T.1
Glodkowska-Mrowka, E.2
Hoser, G.3
Kielak, M.4
Seferynska, I.5
Wlodarski, P.6
-
75
-
-
84890562713
-
Bcr-Abl activates AURKA and AURKB in chronicmyeloid leukemia cells via AKT signaling
-
Yang J, Ikezoe T, Nishioka C, Udaka K, Yokoyama A. Bcr-Abl activates AURKA and AURKB in chronicmyeloid leukemia cells via AKT signaling. Int J Cancer. 2014;134(5):1183-94.
-
(2014)
Int J Cancer
, vol.134
, Issue.5
, pp. 1183-1194
-
-
Yang, J.1
Ikezoe, T.2
Nishioka, C.3
Udaka, K.4
Yokoyama, A.5
-
76
-
-
33846240316
-
MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation
-
DOI 10.1182/blood-2006-05-025049
-
Giles FJ, Cortes J, Jones D, Bergstrom D, Kantarjian H, Freedman SJ. MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation. Blood. 2007;109(2):500-2. (Pubitemid 46105945)
-
(2007)
Blood
, vol.109
, Issue.2
, pp. 500-502
-
-
Giles, F.J.1
Cortes, J.2
Jones, D.3
Bergstrom, D.4
Kantarjian, H.5
Freedman, S.J.6
-
77
-
-
84871888206
-
Downregulation of miR-31, miR-155, and miR-564 in chronic myeloid leukemia cells
-
Rokah OH, Granot G, Ovcharenko A, Modai S, Pasmanik-Chor M, Toren A, et al. Downregulation of miR-31, miR-155, and miR-564 in chronic myeloid leukemia cells. PloS One. 2012;7(4):e35501.
-
(2012)
PloS One
, vol.7
, Issue.4
-
-
Rokah, O.H.1
Granot, G.2
Ovcharenko, A.3
Modai, S.4
Pasmanik-Chor, M.5
Toren, A.6
-
78
-
-
84255197306
-
Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: Long-term observation of 1151 patients from the randomized CML Study IV
-
This study underscores the importance of the early detection of additional cytogenetic abnormalities, which may suggest higher likelihood of blastic transformation and may characterize those patients that need a more aggressive therapeutic intervention at diagnosis
-
• Fabarius A, Leitner A, Hochhaus A, Muller MC, Hanfstein B, Haferlach C, et al. Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV. Blood. 2011;118(26):6760-8. This study underscores the importance of the early detection of additional cytogenetic abnormalities, which may suggest higher likelihood of blastic transformation and may characterize those patients that need a more aggressive therapeutic intervention at diagnosis.
-
(2011)
Blood
, vol.118
, Issue.26
, pp. 6760-6768
-
-
Fabarius, A.1
Leitner, A.2
Hochhaus, A.3
Muller, M.C.4
Hanfstein, B.5
Haferlach, C.6
-
79
-
-
80051752022
-
JAK2V617F mutation in chronic myeloid leukemia predicts early disease progression
-
Pahore ZA, Shamsi TS, Taj M, Farzana T, Ansari SH, Nadeem M, et al. JAK2V617F mutation in chronic myeloid leukemia predicts early disease progression. J Col Physicians Surg Pak. 2011;21(8):472-5.
-
(2011)
J Col Physicians Surg Pak
, vol.21
, Issue.8
, pp. 472-475
-
-
Pahore, Z.A.1
Shamsi, T.S.2
Taj, M.3
Farzana, T.4
Ansari, S.H.5
Nadeem, M.6
-
80
-
-
33750220492
-
RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts
-
Iovino F, Lentini L, Amato A, Di Leonardo A. RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts. Mol Cancer. 2006;5:38.
-
(2006)
Mol Cancer
, vol.5
, pp. 38
-
-
Iovino, F.1
Lentini, L.2
Amato, A.3
Di Leonardo, A.4
-
81
-
-
2642543341
-
Centrosome aberration accompanied with p53 mutation can induce genetic instability in hepatocellular carcinoma
-
DOI 10.1038/modpathol.3800115
-
Nakajima T, Moriguchi M, Mitsumoto Y, Sekoguchi S, Nishikawa T, Takashima H, et al. Centrosome aberration accompanied with p53 mutation can induce genetic instability in hepatocellular carcinoma. Mod Pathol. 2004;17(6):722-7. (Pubitemid 38715497)
-
(2004)
Modern Pathology
, vol.17
, Issue.6
, pp. 722-727
-
-
Nakajima, T.1
Moriguchi, M.2
Mitsumoto, Y.3
Sekoguchi, S.4
Nishikawa, T.5
Takashima, H.6
Watanabe, T.7
Katagishi, T.8
Kimura, H.9
Okanoue, T.10
Kagawa, K.11
-
82
-
-
21744458439
-
Centrosome aberrations in chronic myeloid leukemia correlate with stage of disease and chromosomal instability
-
DOI 10.1038/sj.leu.2403779
-
Giehl M, Fabarius A, Frank O, Hochhaus A, Hafner M, Hehlmann R, et al. Centrosome aberrations in chronic myeloid leukemia correlate with stage of disease and chromosomal instability. Leukemia. 2005;19(7):1192-7. (Pubitemid 40946003)
-
(2005)
Leukemia
, vol.19
, Issue.7
, pp. 1192-1197
-
-
Giehl, M.1
Fabarius, A.2
Frank, O.3
Hochhaus, A.4
Hafner, M.5
Hehlmann, R.6
Seifarth, W.7
-
83
-
-
67749103793
-
Abnormal centrosome-centriole cycle in chronic myeloid leukaemia?
-
Patel H, Gordon MY. Abnormal centrosome-centriole cycle in chronic myeloid leukaemia? Br J Haematol. 2009;146(4):408-17.
-
(2009)
Br J Haematol
, vol.146
, Issue.4
, pp. 408-417
-
-
Patel, H.1
Gordon, M.Y.2
-
84
-
-
84864561201
-
The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib
-
This study shows that treatment with imatinib may further induce centrosome aberations and genomic instability
-
• Haass W, Stehle M, Nittka S, Giehl M, Schrotz-King P, Fabarius A, et al. The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib. PloS One. 2012;7(8):e42863. This study shows that treatment with imatinib may further induce centrosome aberations and genomic instability.
-
(2012)
PloS One
, vol.7
, Issue.8
-
-
Haass, W.1
Stehle, M.2
Nittka, S.3
Giehl, M.4
Schrotz-King, P.5
Fabarius, A.6
-
85
-
-
0017184649
-
Non-random karyotypic evolution in chronic myeloid leukemia
-
Mitelman F, Levan G, Nilsson PG, Brandt L. Non-random karyotypic evolution in chronic myeloid leukemia. Int J Cancer. 1976;18(1):24-30.
-
(1976)
Int J Cancer
, vol.18
, Issue.1
, pp. 24-30
-
-
Mitelman, F.1
Levan, G.2
Nilsson, P.G.3
Brandt, L.4
-
86
-
-
27144466017
-
The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders [1]
-
DOI 10.1182/blood-2005-05-2087
-
Scott LM, Campbell PJ, Baxter EJ, Todd T, Stephens P, Edkins S, et al. The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders. Blood. 2005;106(8):2920-1. (Pubitemid 41510774)
-
(2005)
Blood
, vol.106
, Issue.8
, pp. 2920-2921
-
-
Scott, L.M.1
Campbell, P.J.2
Baxter, E.J.3
Todd, T.4
Stephens, P.5
Edkins, S.6
Richard, W.7
Stratton, M.R.8
Futreal, P.A.9
Green, A.R.10
-
87
-
-
25844518265
-
The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia
-
DOI 10.1182/blood-2005-05-1898
-
Levine RL, Loriaux M, Huntly BJ, Loh ML, Beran M, Stoffregen E, et al. The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia. Blood. 2005;106(10):3377-9. (Pubitemid 41609169)
-
(2005)
Blood
, vol.106
, Issue.10
, pp. 3377-3379
-
-
Levine, R.L.1
Loriaux, M.2
Huntly, B.J.P.3
Loh, M.L.4
Beran, M.5
Stoffregen, E.6
Berger, R.7
Clark, J.J.8
Willis, S.G.9
Nguyen, K.T.10
Flores, N.J.11
Estey, E.12
Gattermann, N.13
Armstrong, S.14
Look, A.T.15
Griffin, J.D.16
Bernard, O.A.17
Heinrich, M.C.18
Gilliland, D.G.19
Druker, B.20
Deininger, M.W.N.21
more..
-
88
-
-
84871988651
-
Recurrent SETBP1 mutations in atypical chronic myeloid leukemia
-
Piazza R, Valletta S, Winkelmann N, Redaelli S, Spinelli R, Pirola A, et al. Recurrent SETBP1 mutations in atypical chronic myeloid leukemia. Nat Genet. 2013;45(1):18-24.
-
(2013)
Nat Genet
, vol.45
, Issue.1
, pp. 18-24
-
-
Piazza, R.1
Valletta, S.2
Winkelmann, N.3
Redaelli, S.4
Spinelli, R.5
Pirola, A.6
-
89
-
-
84863124648
-
Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival
-
Hamilton A, Helgason GV, Schemionek M, Zhang B, Myssina S, Allan EK, et al. Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival. Blood. 2012;119(6):1501-10.
-
(2012)
Blood
, vol.119
, Issue.6
, pp. 1501-1510
-
-
Hamilton, A.1
Helgason, G.V.2
Schemionek, M.3
Zhang, B.4
Myssina, S.5
Allan, E.K.6
-
90
-
-
78650949272
-
Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity
-
Corbin AS, Agarwal A, Loriaux M, Cortes J, Deininger MW, Druker BJ. Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity. J Clin Invest. 2011;121(1):396-409.
-
(2011)
J Clin Invest
, vol.121
, Issue.1
, pp. 396-409
-
-
Corbin, A.S.1
Agarwal, A.2
Loriaux, M.3
Cortes, J.4
Deininger, M.W.5
Druker, B.J.6
-
91
-
-
56649114489
-
BCR-ABL-transformed GMP as myeloid leukemic stem cells
-
Minami Y, Stuart SA, Ikawa T, Jiang Y, Banno A, Hunton IC, et al. BCR-ABL-transformed GMP as myeloid leukemic stem cells. Proc Natl Acad Sci U S A. 2008;105(46):17967-72.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.46
, pp. 17967-17972
-
-
Minami, Y.1
Stuart, S.A.2
Ikawa, T.3
Jiang, Y.4
Banno, A.5
Hunton, I.C.6
-
92
-
-
34249693090
-
Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells
-
DOI 10.1093/jnci/djk150
-
Jiang X, Saw KM, Eaves A, Eaves C. Instability of BCR-ABL gene in primary and cultured chronicmyeloid leukemia stem cells. J Natl Cancer Inst. 2007;99(9):680-93. (Pubitemid 47073530)
-
(2007)
Journal of the National Cancer Institute
, vol.99
, Issue.9
, pp. 680-693
-
-
Jiang, X.1
Saw, K.M.2
Eaves, A.3
Eaves, C.4
-
93
-
-
84860819704
-
Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors
-
This study highlights a possible mechanism of genomic instability in CML stem cells
-
• Nieborowska-Skorska M, Kopinski PK, Ray R, Hoser G, Ngaba D, Flis S, et al. Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors. Blood. 2012;119(18):4253-63. This study highlights a possible mechanism of genomic instability in CML stem cells.
-
(2012)
Blood
, vol.119
, Issue.18
, pp. 4253-4263
-
-
Nieborowska-Skorska, M.1
Kopinski, P.K.2
Ray, R.3
Hoser, G.4
Ngaba, D.5
Flis, S.6
-
94
-
-
84881017449
-
Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells
-
This study shows that oxidative DNA damage may occur in LSCs independently of BCR-ABL1
-
• Bolton-Gillespie E, Schemionek M, Klein HU, Flis S, Hoser G, Lange T, et al. Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells. Blood. 2013;121(20):4175-83. This study shows that oxidative DNA damage may occur in LSCs independently of BCR-ABL1.
-
(2013)
Blood
, vol.121
, Issue.20
, pp. 4175-4183
-
-
Bolton-Gillespie, E.1
Schemionek, M.2
Klein, H.U.3
Flis, S.4
Hoser, G.5
Lange, T.6
-
95
-
-
84887392984
-
JAK of all trades: JAK2-STAT5 as novel therapeutic targets in BCR-ABL1+ chronic myeloid leukemia
-
Warsch W, Walz C, Sexl V. JAK of all trades: JAK2-STAT5 as novel therapeutic targets in BCR-ABL1+ chronic myeloid leukemia. Blood. 2013;122(13):2167-75.
-
(2013)
Blood
, vol.122
, Issue.13
, pp. 2167-2175
-
-
Warsch, W.1
Walz, C.2
Sexl, V.3
-
96
-
-
84880214905
-
Roles of SIRT1 in leukemogenesis
-
Chen W, Bhatia R. Roles of SIRT1 in leukemogenesis. Curr Opin Hematol. 2013;20(4):308-13.
-
(2013)
Curr Opin Hematol
, vol.20
, Issue.4
, pp. 308-313
-
-
Chen, W.1
Bhatia, R.2
-
97
-
-
84882913815
-
Selective elimination of leukemia stem cells: Hitting a moving target
-
Crews LA, Jamieson CH. Selective elimination of leukemia stem cells: hitting a moving target. Cancer Lett. 2013;338(1):15-22.
-
(2013)
Cancer Lett
, vol.338
, Issue.1
, pp. 15-22
-
-
Crews, L.A.1
Jamieson, C.H.2
-
98
-
-
84885085996
-
PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells
-
Neviani P, Harb JG, Oaks JJ, Santhanam R, Walker CJ, Ellis JJ, et al. PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. J Clin Invest. 2013;123(10):4144-57.
-
(2013)
J Clin Invest
, vol.123
, Issue.10
, pp. 4144-4157
-
-
Neviani, P.1
Harb, J.G.2
Oaks, J.J.3
Santhanam, R.4
Walker, C.J.5
Ellis, J.J.6
-
99
-
-
84875131206
-
A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition
-
Goff DJ, Recart AC, Sadarangani A, Chun HJ, Barrett CL, Krajewska M, et al. A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell. 2013;12(3):316-28.
-
(2013)
Cell Stem Cell
, vol.12
, Issue.3
, pp. 316-328
-
-
Goff, D.J.1
Recart, A.C.2
Sadarangani, A.3
Chun, H.J.4
Barrett, C.L.5
Krajewska, M.6
-
100
-
-
84863011183
-
Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib
-
Li L, Wang L, Li L, Wang Z, Ho Y, McDonald T, et al. Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib. Cancer Cell. 2012;21(2):266-81.
-
(2012)
Cancer Cell
, vol.21
, Issue.2
, pp. 266-281
-
-
Li, L.1
Wang, L.2
Li, L.3
Wang, Z.4
Ho, Y.5
McDonald, T.6
-
101
-
-
66449122303
-
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells
-
Bellodi C, Lidonnici MR, Hamilton A, Helgason GV, Soliera AR, Ronchetti M, et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest. 2009;119(5):1109-23.
-
(2009)
J Clin Invest
, vol.119
, Issue.5
, pp. 1109-1123
-
-
Bellodi, C.1
Lidonnici, M.R.2
Hamilton, A.3
Helgason, G.V.4
Soliera, A.R.5
Ronchetti, M.6
-
102
-
-
84896700690
-
Inhibition of autophagy augments the anticancer activity of alpha-mangostin in chronic myeloid leukemia cells
-
Liu LL
-
Chen JJ, Long ZJ, Xu DF. Xiao RZ. Xu ZF, et al. Inhibition of autophagy augments the anticancer activity of alpha-mangostin in chronic myeloid leukemia cells. Leuk Lymphoma: Liu LL; 2013.
-
(2013)
Leuk Lymphoma
-
-
Chen, J.J.1
Long, Z.J.2
Xu, D.F.3
Xiao, R.Z.4
Xu, Z.F.5
-
103
-
-
84858032395
-
Targeting of GSK3beta promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells
-
Reddiconto G, Toto C, Palama I, De Leo S, de Luca E, De Matteis S, et al. Targeting of GSK3beta promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells. Blood. 2012;119(10):2335-45.
-
(2012)
Blood
, vol.119
, Issue.10
, pp. 2335-2345
-
-
Reddiconto, G.1
Toto, C.2
Palama, I.3
De Leo, S.4
De Luca, E.5
De Matteis, S.6
|