메뉴 건너뛰기




Volumn 119, Issue 12, 2012, Pages 2873-2882

Functional features of RUNX1 mutants in acute transformation of chronic myeloid leukemia and their contribution to inducing murine full-blown leukemia

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; COMPLEMENTARY DNA; GENOMIC DNA; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; RETROVIRUS VECTOR; TRANSCRIPTION FACTOR RUNX1; YELLOW FLUORESCENT PROTEIN;

EID: 84863356975     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-08-370981     Document Type: Article
Times cited : (47)

References (46)
  • 1
    • 0034670036 scopus 로고    scopus 로고
    • The molecular biology of chronic myeloid leukemia
    • Deininger MW, Goldman JM, Melo JV. The molecular biology of chronic myeloid leukemia. Blood. 2000;96(10):3343-3356.
    • (2000) Blood , vol.96 , Issue.10 , pp. 3343-3356
    • Deininger, M.W.1    Goldman, J.M.2    Melo, J.V.3
  • 2
    • 66549101521 scopus 로고    scopus 로고
    • Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia
    • Miyazaki K, Yamasaki N, Oda H, et al. Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia. Blood. 2009; 113(19):4702-4710.
    • (2009) Blood , vol.113 , Issue.19 , pp. 4702-4710
    • Miyazaki, K.1    Yamasaki, N.2    Oda, H.3
  • 3
    • 14644425319 scopus 로고    scopus 로고
    • Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
    • DOI 10.1038/nrc1567
    • Ren R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer. 2005;5(3):172-183. (Pubitemid 40314949)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.3 , pp. 172-183
    • Ren, R.1
  • 6
    • 2542500611 scopus 로고    scopus 로고
    • The biology of CML blast crisis
    • DOI 10.1182/blood-2003-12-4111
    • Calabretta B, Perrotti D. The biology of CML blast crisis. Blood. 2004;103(11):4010-4022. (Pubitemid 38685338)
    • (2004) Blood , vol.103 , Issue.11 , pp. 4010-4022
    • Calabretta, B.1    Perrotti, D.2
  • 7
    • 0035857078 scopus 로고    scopus 로고
    • Cooperation of BCR-ABL and AML1/MDS1/EVI1 in blocking myeloid differentiation and rapid induction of an acute myelogenous leukemia
    • Cuenco GM, Ren R. Cooperation of BCR-ABL and AML1/MDS1/EVI1 in blocking myeloid differentiation and rapid induction of an acute myelogenous leukemia. Oncogene. 2001;20(57):8236- 8248.
    • (2001) Oncogene , vol.20 , Issue.57 , pp. 8236-8248
    • Cuenco, G.M.1    Ren, R.2
  • 8
    • 0036892511 scopus 로고    scopus 로고
    • Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging culture system
    • DOI 10.1182/blood-2002-04-1244
    • Mayotte N, Roy DC, Yao J, Kroon E, Sauvageau G. Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging culture system. Blood. 2002; 100(12):4177-4184. (Pubitemid 35396886)
    • (2002) Blood , vol.100 , Issue.12 , pp. 4177-4184
    • Mayotte, N.1    Roy, D.-C.2    Yao, J.3    Kroon, E.4    Sauvageau, G.5
  • 10
    • 0029019659 scopus 로고
    • Aml1 and the 8-21 and 3-21 Translocations in Acute and Chronic Myeloid- Leukemia
    • Nucifora G, Rowley JD. Aml1 and the 8-21 and 3-21 Translocations in Acute and Chronic Myeloid- Leukemia. Blood. 1995;86(1):1-14.
    • (1995) Blood , vol.86 , Issue.1 , pp. 1-14
    • Nucifora, G.1    Rowley, J.D.2
  • 11
    • 0033559746 scopus 로고    scopus 로고
    • Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias
    • Osato M, Asou N, Abdalla E, et al. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias. Blood. 1999;93(6):1817- 1824.
    • (1999) Blood , vol.93 , Issue.6 , pp. 1817-1824
    • Osato, M.1    Asou, N.2    Abdalla, E.3
  • 12
    • 0036902961 scopus 로고    scopus 로고
    • Core binding factor genes and human leukemia
    • Hart SM, Foroni L. Core binding factor genes and human leukemia. Haematologica. 2002;87(12): 1307-1323. (Pubitemid 36005305)
    • (2002) Haematologica , vol.87 , Issue.12 , pp. 1307-1323
    • Hart, S.M.1    Foroni, L.2
  • 13
    • 73949090504 scopus 로고    scopus 로고
    • AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: Prognostic implication and interaction with other gene alterations
    • Tang JL, Hou HA, Chen CY, et al. AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations. Blood. 2009;114(26):5352-5361.
    • (2009) Blood , vol.114 , Issue.26 , pp. 5352-5361
    • Tang, J.L.1    Hou, H.A.2    Chen, C.Y.3
  • 15
    • 43549086237 scopus 로고    scopus 로고
    • RUNX1 DNA-binding mutations and RUNX1- PRDM16 cryptic fusions in BCR-ABL+ leukemias are frequently associated with secondary trisomy 21 and may contribute to clonal evolution and imatinib resistance
    • Roche-Lestienne C, Deluche L, Corm S, et al. RUNX1 DNA-binding mutations and RUNX1- PRDM16 cryptic fusions in BCR-ABL+ leukemias are frequently associated with secondary trisomy 21 and may contribute to clonal evolution and imatinib resistance. Blood. 2008;111(7):3735- 3741.
    • (2008) Blood , vol.111 , Issue.7 , pp. 3735-3741
    • Roche-Lestienne, C.1    Deluche, L.2    Corm, S.3
  • 16
    • 79952451556 scopus 로고    scopus 로고
    • A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases
    • Grossmann V, Kohlmann A, Zenger M, et al. A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases. Leukemia. 2011;25(3): 557-560.
    • (2011) Leukemia , vol.25 , Issue.3 , pp. 557-560
    • Grossmann, V.1    Kohlmann, A.2    Zenger, M.3
  • 17
    • 41149169150 scopus 로고    scopus 로고
    • Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia
    • Zhang SJ, Ma LY, Huang QH, et al. Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia. Proc Natl Acad Sci U S A. 2008;105(6):2076-2081.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.6 , pp. 2076-2081
    • Zhang, S.J.1    Ma, L.Y.2    Huang, Q.H.3
  • 18
    • 79952286086 scopus 로고    scopus 로고
    • C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice
    • Wang YY, Zhao LJ, Wu CF, et al. C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice. Proc Natl Acad Sci U S A. 2011;108(6):2450-2455.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.6 , pp. 2450-2455
    • Wang, Y.Y.1    Zhao, L.J.2    Wu, C.F.3
  • 19
    • 0037438508 scopus 로고    scopus 로고
    • Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia
    • DOI 10.1182/blood-2002-04-1010
    • Harada H, Harada Y, Tanaka H, Kimura A, Inaba T. Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia. Blood. 2003;101(2):673-680. (Pubitemid 36077592)
    • (2003) Blood , vol.101 , Issue.2 , pp. 673-680
    • Harada, H.1    Harada, Y.2    Tanaka, H.3    Kimura, A.4    Inaba, T.5
  • 20
    • 0042856303 scopus 로고    scopus 로고
    • SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo
    • DOI 10.1038/sj.onc.1206600
    • Chakraborty S, Sinha KK, Senyuk V, Nucifora G. SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo. Oncogene. 2003;22(34):5229-5237. (Pubitemid 37056085)
    • (2003) Oncogene , vol.22 , Issue.34 , pp. 5229-5237
    • Chakraborty, S.1    Sinha, K.K.2    Senyuk, V.3    Nucifora, G.4
  • 22
    • 0031779074 scopus 로고    scopus 로고
    • The Wilms' tumor suppressor WT1: Approaches to gene function
    • DOI 10.1046/j.1523-1755.1998.00935.x
    • Menke A, McInnes L, Hastie ND, Schedl A. The Wilms' tumor suppressor WT1: approaches to gene function. Kidney Int. 1998;53(6):1512-1518. (Pubitemid 28243735)
    • (1998) Kidney International , vol.53 , Issue.6 , pp. 1512-1518
    • Menke, A.1    Mcinnes, L.2    Hastie, N.D.3    Schedl, A.4
  • 25
    • 0030061554 scopus 로고    scopus 로고
    • AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
    • DOI 10.1016/S0092-8674(00)80986-1
    • Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 1996;84(2):321-330. (Pubitemid 26042836)
    • (1996) Cell , vol.84 , Issue.2 , pp. 321-330
    • Okuda, T.1    Van Deursen, J.2    Hiebert, S.W.3    Grosveld, G.4    Downing, J.R.5
  • 26
    • 0034332068 scopus 로고    scopus 로고
    • Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesis
    • Imai Y, Kurokawa M, Izutsu K, et al. Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesis. Blood. 2000;96(9):3154-3160.
    • (2000) Blood , vol.96 , Issue.9 , pp. 3154-3160
    • Imai, Y.1    Kurokawa, M.2    Izutsu, K.3
  • 27
    • 0027984233 scopus 로고
    • Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1)
    • Zhang DE, Fujioka K, Hetherington CJ, et al. Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1). Mol Cell Biol. 1994;14(12):8085-8095. (Pubitemid 24373557)
    • (1994) Molecular and Cellular Biology , vol.14 , Issue.12 , pp. 8085-8095
    • Zhang, D.-E.1    Fujioka, K.-I.2    Hetherington, C.J.3    Shapiro, L.H.4    Chen, H.-M.5    Look, A.T.6    Tenen, D.G.7
  • 28
    • 0031706178 scopus 로고    scopus 로고
    • Identification of an upstream enhancer containing an AML1 site in the human myeloperoxidase (MPO) gene
    • DOI 10.1016/S0145-2126(98)00105-2, PII S0145212698001052
    • Austin GE, Zhao WG, Regmi A, Lu JP, Braun J. Identification of an upstream enhancer containing an AML1 site in the human myeloperoxidase (MPO) gene. Leukemia Research. 1998;22(11): 1037-1048. (Pubitemid 28454504)
    • (1998) Leukemia Research , vol.22 , Issue.11 , pp. 1037-1048
    • Austin, G.E.1    Zhao, W.-G.2    Regmi, A.3    Lu, J.-P.4    Braun, J.5
  • 30
    • 0030842463 scopus 로고    scopus 로고
    • A conserved tissue-specific structure at a human T-cell receptor beta-chain core promoter
    • Halle JP, HausSeuffert P, Woltering C, Stelzer G, Meisterernst M. A conserved tissue-specific structure at a human T-cell receptor beta-chain core promoter. Mol Cell Biol. 1997;17(8):4220-4229.
    • (1997) Mol Cell Biol , vol.17 , Issue.8 , pp. 4220-4229
    • Halle, J.P.1    HausSeuffert, P.2    Woltering, C.3    Stelzer, G.4    Meisterernst, M.5
  • 31
    • 77956550865 scopus 로고    scopus 로고
    • The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes
    • Bakshi R, Hassan MQ, Pratap J, et al. The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes. J Cell Physiol. 2010;225(2):569-576.
    • (2010) J Cell Physiol , vol.225 , Issue.2 , pp. 569-576
    • Bakshi, R.1    Hassan, M.Q.2    Pratap, J.3
  • 32
    • 0031092629 scopus 로고    scopus 로고
    • AML1A and AML1B Can Transactivate the Human IL-3 Promoter
    • Uchida H, Zhang J, Nimer SD. AML1A and AML1B can transactivate the human IL-3 promoter. J Immunol. 1997;158(5):2251-2258. (Pubitemid 127470009)
    • (1997) Journal of Immunology , vol.158 , Issue.5 , pp. 2251-2258
    • Uchida, H.1    Zhang, J.2    Nimer, S.D.3
  • 34
    • 0031785159 scopus 로고    scopus 로고
    • A role for Groucho tetramerization in transcriptional repression
    • Chen G, Nguyen PH, Courey AJ. A role for Groucho tetramerization in transcriptional repression. Mol Cell Biol. 1998;18(12):7259-7268. (Pubitemid 28533045)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.12 , pp. 7259-7268
    • Chen, G.1    Nguyen, P.H.2    Courey, A.J.3
  • 35
    • 0028952841 scopus 로고
    • Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms
    • Jeffrey PD, Gorina S, Pavletich NP. Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms. Science. 1995; 267(5203):1498-1502.
    • (1995) Science , vol.267 , Issue.5203 , pp. 1498-1502
    • Jeffrey, P.D.1    Gorina, S.2    Pavletich, N.P.3
  • 37
    • 17144463437 scopus 로고    scopus 로고
    • A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein
    • DOI 10.1093/emboj/16.1.69
    • Jousset C, Carron C, Boureux A, et al. A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein. EMBO J. 1997;16(1):69-82. (Pubitemid 27032851)
    • (1997) EMBO Journal , vol.16 , Issue.1 , pp. 69-82
    • Jousset, C.1    Carron, C.2    Boureux, A.3    Quang, C.T.4    Oury, C.5    Dusanter-Fourt, I.6    Charon, M.7    Levin, J.8    Bernard, O.9    Ghysdael, J.10
  • 38
    • 0033638969 scopus 로고    scopus 로고
    • Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation
    • Minucci S, Maccarana M, Cioce M, et al. Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation. Molecular Cell. 2000;5(5):811-820.
    • (2000) Molecular Cell , vol.5 , Issue.5 , pp. 811-820
    • Minucci, S.1    Maccarana, M.2    Cioce, M.3
  • 39
    • 62449178451 scopus 로고    scopus 로고
    • Transforming activity of AML1-ETO is independent of CBF beta and ETO interaction but requires formation of homo-oligomeric complexes
    • Kwok C, Zeisig BB, Qiu JH, Dong SO, So CWE. Transforming activity of AML1-ETO is independent of CBF beta and ETO interaction but requires formation of homo-oligomeric complexes. Proc Natl Acad Sci U S A. 2009;106(8):2853- 2858.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.8 , pp. 2853-2858
    • Kwok, C.1    Zeisig, B.B.2    Qiu, J.H.3    Dong, S.O.4    So, C.W.E.5
  • 40
    • 24744432337 scopus 로고    scopus 로고
    • The distal zinc finger domain of AML1/MDS1/EVI1 is an oligomerization domain involved in induction of hematopoietic differentiation defects in primary cells in vitro
    • DOI 10.1158/0008-5472.CAN-05-0412
    • Senyuk V, Li D, Zakharov A, Mikhail FM, Nucifora G. The distal zinc finger domain of AML1/MDS1/EVI1 is an oligomerization domain involved in induction of hematopoietic differentiation defects in primary cells in vitro. Cancer Res. 2005;65(17):7603-7611. (Pubitemid 41297232)
    • (2005) Cancer Research , vol.65 , Issue.17 , pp. 7603-7611
    • Senyuk, V.1    Li, D.2    Zakharov, A.3    Mikhail, F.M.4    Nucifora, G.5
  • 42
    • 0028839054 scopus 로고
    • Subcellular localization of the alpha-subunits and betasubunits of the acute myeloid leukemia-linked transcription factor Pebp2/Cbf
    • Lu J, Maruyama M, Satake M, et al. Subcellular localization of the alpha-subunits and betasubunits of the acute myeloid leukemia-linked transcription factor Pebp2/Cbf. Mol Cell Biol. 1995;15(3):1651-1661.
    • (1995) Mol Cell Biol , vol.15 , Issue.3 , pp. 1651-1661
    • Lu, J.1    Maruyama, M.2    Satake, M.3
  • 43
    • 2942667930 scopus 로고    scopus 로고
    • Point mutations in the RUNX1/AML1 gene: Another actor in RUNX leukemia
    • DOI 10.1038/sj.onc.1207779
    • Osato M. Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia. Oncogene. 2004;23(24):4284-4296. (Pubitemid 38765137)
    • (2004) Oncogene , vol.23 , Issue.24 , pp. 4284-4296
    • Osato, M.1
  • 44
    • 73949129831 scopus 로고    scopus 로고
    • AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms
    • Ding Y, Harada Y, Imagawa J, Kimura A, Harada H. AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms. Blood. 2009;114(25):5201- 5205.
    • (2009) Blood , vol.114 , Issue.25 , pp. 5201-5205
    • Ding, Y.1    Harada, Y.2    Imagawa, J.3    Kimura, A.4    Harada, H.5
  • 45
    • 43249103972 scopus 로고    scopus 로고
    • AML1 mutations induced MDS and MDS/AML in a mouse BMT model
    • Watanabe-Okochi N, Kitaura J, Ono R, et al. AML1 mutations induced MDS and MDS/AML in a mouse BMT model. Blood. 2008;111(8):4297- 4308.
    • (2008) Blood , vol.111 , Issue.8 , pp. 4297-4308
    • Watanabe-Okochi, N.1    Kitaura, J.2    Ono, R.3
  • 46
    • 34249694973 scopus 로고    scopus 로고
    • Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1
    • Tsuzuki S, Hong D, Gupta R, Matsuo K, Seto M, Enver T. Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1. PLoS Med. 2007;4(5):e172.
    • (2007) PLoS Med , vol.4 , Issue.5
    • Tsuzuki, S.1    Hong, D.2    Gupta, R.3    Matsuo, K.4    Seto, M.5    Enver, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.