EVI1 activation in blast crisis CML due to juxtaposition to the rare 17q22 partner region as part of a 4-way variant translocation t(9;22)

BMC Cancer

Volumn 8, Issue , 2008, Pages

  De Weer, An ^a   Poppe, Bruce ^a   Cauwelier, Barbara ^a,b   Carlier, Andre ^c   Dierick, Jan ^b   Verhasselt, Bruno ^a   Philippé, Jan ^a   Van Roy, Nadine ^a   Speleman, Frank ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b AZ Sint Jan AV ^*  (Belgium)

^c Maria Middelares Hospital   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; TRANSCRIPTION FACTOR RUNX1; DNA BINDING PROTEIN; EVI1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ARTICLE; BLAST CELL CRISIS; CASE REPORT; CHROMOSOME 22; CHROMOSOME 9; CHROMOSOME ABERRATION; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE IDENTIFICATION; GENE LOCUS; GENE OVEREXPRESSION; GENE TARGETING; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; PHENOTYPE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; BIOSYNTHESIS; CHROMOSOME 3; CHROMOSOME ANALYSIS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; ONCOGENE; PATHOLOGY; PHILADELPHIA 1 CHROMOSOME; PROTO ONCOGENE; TRANSCRIPTION INITIATION;

BLAST CRISIS; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 22; CHROMOSOMES, HUMAN, PAIR 3; CHROMOSOMES, HUMAN, PAIR 9; CYTOGENETIC ANALYSIS; DNA-BINDING PROTEINS; FUSION PROTEINS, BCR-ABL; GENE EXPRESSION REGULATION, LEUKEMIC; GENES, ABL; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; PHILADELPHIA CHROMOSOME; PROTO-ONCOGENES; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 48249114377     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-8-193     Document Type: Article

References (16)

1. Goldman JM Melo JV Chronic myeloid leukemia - advances in biology and new approaches to treatment The New England journal of medicine 2003, 349(15):1451-1464. 10.1056/NEJMra020777 14534339
2. Johansson B Fioretos T Mitelman F Cytogenetic and molecular genetic evolution of chronic myeloid leukemia Acta haematologica 2002, 107(2):760-94. 10.1159/000046636 11919388
3. Ogawa S Kurokawa M Tanaka T Tanaka K Hangaishi A Mitani K Kamada N Yazaki Y Hirai H Increased Evi-1 expression is frequently observed in blastic crisis of chronic myelocytic leukemia Leukemia 1996, 10(5):788-794. 8656673
4. Lugthart S Drunen EV Norden YV Hoven AV Erpelinck CA Valk PJ Beverloo HB Lowenberg B Delwel R High EVI1 levels predict adverse outcome in acute myeloid leukemia: Prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated. Blood 2008. 18272813
5. Buonamici S Chakraborty S Senyuk V Nucifora G The role of EVI1 in normal and leukemic cells Blood cells, molecules & diseases 2003, 31(2):206-212. 10.1016/S1079-9796(03)00159-1 12972028
6. Shaffer L Tommerup N (eds) ISCN 2005: An international system for human cytogenetic nomenclature Basel: S. Karger 2005.
7. Van Limbergen H Poppe B Michaux L Herens C Brown J Noens L Berneman Z De Bock R De Paepe A Speleman F Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH Genes, chromosomes & cancer 2002, 33(1):60-72. 10.1002/gcc.1212 11746988
8. Van Roy N Vandesompele J Berx G Staes K Van Gele M De Smet E De Paepe A Laureys G Drift van der P Versteeg R Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type 1 patients Genes, chromosomes & cancer 2002, 35(2):113-120. 10.1002/ gcc.10034 12203774
9. Poppe B Dastugue N Vandesompele J Cauwelier B De Smet B Yigit N De Paepe A Cervera J Recher C De Mas V EVI1 is consistently expressed as principal transcript in common and rare recurrent 3q26 rearrangements Genes, chromosomes & cancer 2006, 45(4):349-356. 10.1002/gcc.20295 16342172
10. Vandesompele J De Preter K Pattyn F Poppe B Van Roy N De Paepe A Speleman F Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes Genome biology 2002, 3(7):1-11. 10.1186/gb-2002-3-7-research0034
11. Gabert J Beillard E Velden van der VH Bi W Grimwade D Pallisgaard N Barbany G Cazzaniga G Cayuela JM Cave H Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program Leukemia 2003, 17(12):2318-2357. 10.1038/sj.leu.2403135 14562125
12. Gorusu M Benn P Li Z Fang M On the genesis and prognosis of variant translocations in chronic myeloid leukemia Cancer genetics and cytogenetics 2007, 173(2):97-106. 10.1016/j.cancergencyto.2006.10.006
13. Barjesteh van Waalwijk van Doorn-Khosrovani S Erpelinck C van Putten WL Valk PJ Poel-van de Luytgaarde van der S Hack R Slater R Smit EM Beverloo HB Verhoef G High EVI1 expression predicts poor survival in acute myeloid leukemia: A study of 319 de novo AML patients Blood 2003, 101(3):837-845. 10.1182/blood-2002-05-1459 12393383
14. Haas K Kundi M Sperr WR Esterbauer H Ludwig WD Ratei R Koller E Gruener H Sauerland C Fonatsch C Expression and prognostic significance of different mRNA 5'-end variants of the oncogene EVI1 in 266 patients with de novo AML: EVI1 and MDS1/EVI1 overexpression both predict short remission duration Genes Chromosomes Cancer 2008, 47(4):288-298. 10.1002/ gcc.20532 18181178
15. Jabbour E Cortes JE Ghanem H O'Brien S Kantarjian HM Targeted therapy in chronic myeloid leukemia Expert Rev Anticancer Ther 2008, 8(1):99-110. 10.1586/14737140.8.1.99 18095887
16. Wieser R The oncogene and developmental regulator EVI1: Expression, biochemical properties, and biological functions Gene 2007, 396(2):346-357. 10.1016/j.gene.2007.04.012 17507183