MR-1 blocks the megakaryocytic differentiation and transition of CML from chronic phase to blast crisis through MEK dephosphorylation

Blood Cancer Journal

Volumn 3, Issue 3, 2013, Pages

  Zhao, W ^a   He, H ^a   Ren, K ^a   Li, B ^a   Zhang, H ^a   Lin, Y ^a,b   Shao, R G ^a,c  

^a BEIJING HOSPITAL   (China)

^b BEIJING HOSPITAL   (China)

^c INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

Blast crisis; Chronic myeloid leukemia; ERK; Megakaryocytic differentiation; MEK; MR 1

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MYOFIBRILLOGENESIS REGULATOR 1; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BLAST CELL CRISIS; BONE MARROW CELL; CANCER GROWTH; CELL DIFFERENTIATION; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; NUCLEOTIDE SEQUENCE; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

EID: 84878270797     PISSN: None     EISSN: 20445385     Source Type: Journal    
DOI: 10.1038/bcj.2013.5     Document Type: Article

References (38)

1. Savage DG, Szydlo RM, Goldman JM. Clinical features at diagnosis in 430 patients with chronic myeloid leukaemia seen at a referral centre over a 16-year period. Br J Haematol 1997; 96: 111-116.
2. Calabretta B, Perrotti D. The biology of CML blast crisis. Blood 2004; 103: 4010-4022. (Pubitemid 38685338)
3. Li TB, Liu XH, Feng S, Hu Y, Yang WX, Han Y et al. Characterization of MR-1, a novel myofibrillogenesis regulator in human muscle. Acta Biochim Biophys Sin (Shanghai) 2004; 36: 412-418. (Pubitemid 39091572)
4. Ren K, Jin H, Bian C, He H, Liu X, Zhang S et al. MR-1 modulates proliferation and migration of human hepatoma HepG2 cells through myosin light chains-2 (MLC2)/focal adhesion kinase (FAK)/Akt signaling pathway. J Biol Chem 2008; 283: 35598-35605.
5. Lu R, Sun M, Feng J, Gao X, Guo L. Myofibrillogenesis regulator 1 (MR-1) is a novel biomarker and potential therapeutic target for human ovarian cancer. BMC Cancer 2011; 11: 270-279.
6. Lozzio BB, Lozzio CB. Properties of the K562 cell line derived from a patient with chronic myeloid leukemia. Int J Cancer 1976; 18: 421-431.
7. Ogura M, Morishima Y, Ohno R, Kato Y, Hirabayashi N, Nagura H et al. Establishment of a novel human megakaryoblastic leukemia cell line, MEG-01, with positive Philadelphia chromosome. Blood 1985; 66: 1384-1392. (Pubitemid 16194703)
8. Seigneurin D, Champelovier P, Mouchiroud G, Berthier R, Leroux D, Prenant M et al. Human chronic myeloid leukemic cell line with positive Philadelphia chromosome exhibits megakaryocytic and erythroid characteristics. Exp Hematol 1987; 15: 822-832. (Pubitemid 18007089)
9. Kawano T, Horiguchi-Yamada J, Iwase S, Furukawa Y, Kano Y, Yamada H. Inactivation of ERK accelerates erythroid differentiation of K562 cells induced by herbimycin A and STI571 while activation of MEK1 interferes with it. Mol Cell Biochem 2004; 258: 25-33. (Pubitemid 38268197)
10. Genever PG, Wilkinson DJ, Patton AJ, Peet NM, Hong Y, Mathur A et al. Expression of a functional N-methyl-D-aspartate-type glutamate receptor by bone marrow megakaryocytes. Blood 1999; 93: 2876-2883. (Pubitemid 29200778)
11. Levay K, Slepak VZ. Tescalcin is an essential factor in megakaryocytic differentiation associated with Ets family gene expression. J Clin Invest 2007; 117: 2672-2683. (Pubitemid 47494367)
12. Herrera R, Hubbell S, Decker S, Petruzzelli L. A role for the MEK/MAPK pathway in PMA-induced cell cycle arrest: Modulation of megakaryocytic differentiation of K562 cells. Exp Cell Res 1998; 238: 407-414. (Pubitemid 28372828)
13. Long MW, Heffner CH, Williams JL, Peters C, Prochownik EV. Regulation of megakaryocyte phenotype in human erythroleukemia cells. J Clin Invest 1990; 85: 1072-1084. (Pubitemid 20123748)
14. Colamonici OR, Trepel JB, Neckers LM. Phorbol ester enhances deoxynucleoside incorporation while inhibiting proliferation of K-562 cells. Cytometry 1985; 6: 591-596. (Pubitemid 16257690)
15. Sokal JE, Cox EB, Baccarani M, Tura S, Gomez GA, Robertson JE et al. Prognostic discrimination in 'good-risk' chronic granulocytic leukemia. Blood 1984; 63: 789-799. (Pubitemid 14141296)
16. Chen XL, Ren KH, He HW, Shao RG. Involvement of PI3K/AKT/GSK3beta pathway in tetrandrine-induced G1 arrest and apoptosis. Cancer Biol Ther 2008; 7: 1073-1078.
17. Ferrero GO, Velazquez FN, Caputto BL. The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity. Oncogene 2012; 31: 3381-3391.
18. Evans JP, Wickremasinghe RG, Hoffbrand AV. Tyrosine protein kinase substrates in Philadelphia-positive human chronic granulocytic leukemia derived cell lines (K562 and BV173): Detection by using an immunoblotting technique. Leukemia 1987; 1: 524-525. (Pubitemid 18004794)
19. Bandyopadhyay G, Biswas T, Roy KC, Mandal S, Mandal C, Pal BC et al. Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells. Blood 2004; 104: 2514-2522. (Pubitemid 39331855)
20. Severin S, Ghevaert C, Mazharian A. The mitogen-activated protein kinase signaling pathways: Role in megakaryocyte differentiation. J Thromb Haemost 2010; 8: 17-26.
21. Melemed AS, Ryder JW, Vik TA. Activation of the mitogen-activated protein kinase pathway is involved in and sufficient for megakaryocytic differentiation of CMK cells. Blood 1997; 90: 3462-3470. (Pubitemid 27473416)
22. Miyazaki R, Ogata H, Kobayashi Y. Requirement of thrombopoietin-induced activation of ERK for megakaryocyte differentiation and of p38 for erythroid differentiation. Ann Hematol 2001; 80: 284-291. (Pubitemid 32515050)
23. Guerriero R, Mattia G, Testa U, Chelucci C, Macioce G, Casella I et al. Stromal cellderived factor 1alpha increases polyploidization of megakaryocytes generated by human hematopoietic progenitor cells. Blood 2001; 97: 2587-2595.
24. Shelton JG, Moye PW, Steelman LS, Blalock WL, Lee JT, Franklin RA et al. Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation. Leukemia 2003; 17: 1765-1782. (Pubitemid 37185253)
25. Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 2010; 464: 427-430.
26. Radich JP. The Biology of CML blast crisis. Hematology Am Soc Hematol Educ Program 2007 384-391.
27. Schulze H, Korpal M, Hurov J, Kim SW, Zhang J, Cantley LC et al. Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. Blood 2006; 107: 3868-3875. (Pubitemid 43726790)
28. Mathur A, Hong Y, Wang G, Erusalimsky JD. Assays of megakaryocyte development: Surface antigen expression, ploidy, and size. Methods Mol Biol 2004; 272: 309-322.
29. Chang YI, Hua WK, Yao CL, Hwang SM, Hung YC, Kuan CJ et al. Proteinarginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells. J Biol Chem 2010; 285: 20595-20606.
30. Whalen AM, Galasinski SC, Shapiro PS, Nahreini TS, Ahn NG. Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase. Mol Cell Biol 1997; 17: 1947-1958. (Pubitemid 27133279)
31. Racke FK, Lewandowska K, Goueli S, Goldfarb AN. Sustained activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway is required for megakaryocytic differentiation of K562 cells. J Biol Chem 1997; 272: 23366-23370. (Pubitemid 27392477)
32. Balmanno K, Cook SJ. Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells. Oncogene 1999; 18: 3085-3097. (Pubitemid 29261229)
33. Coqueret O. Linking cyclins to transcriptional control. Gene 2002; 299: 35-55. (Pubitemid 35379826)
34. Coqueret O. New roles for p21 and p27 cell-cycle inhibitors: A function for each cell compartment? Trends Cell Biol 2003; 13: 65-70. (Pubitemid 36135887)
35. Colosetti P, Puissant A, Robert G, Luciano F, Jacquel A, Gounon P et al. Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line. Autophagy 2009; 5: 1092-1098.
36. Meshkini A, Yazdanparast R. Involvement of ERK/MAPK pathway in megakaryocytic differentiation of K562 cells induced by 3-hydrogenkwadaphnin. Toxicol In Vitro 2008; 22: 1503-1510.
37. Vitrat N, Cohen-Solal K, Pique C, Le Couedic JP, Norol F, Larsen AK et al. Endomitosis of human megakaryocytes are due to abortive mitosis. Blood 1998; 91: 3711-3723. (Pubitemid 28225739)
38. Wilhide CC, Van Dang C, Dipersio J, Kenedy AA, Bray PF. Overexpression of cyclin D1 in the Dami megakaryocytic cell line causes growth arrest. Blood 1995; 86: 294-304.