Activation of PI3K/Akt signaling in rostral ventrolateral medulla impairs brain stem cardiovascular regulation that underpins circulatory depression during mevinphos intoxication

Biochemical Pharmacology

Volumn 88, Issue 1, 2014, Pages 75-85

  Tsai, Ching Yi ^a   Chang, Alice Y W ^a   Chan, Julie Y H ^a   Chan, Samuel H H ^a  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Impairment of brain stem cardiovascular regulation; Mevinphos intoxication; NOS II peroxynitrite cascade; PI3K Akt NF B signaling; Rostral ventrolateral medulla

Indexed keywords

BETA ACTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MEVINPHOS; PEROXYNITRITE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM CARDIOVASCULAR REGULATION; BRAIN STEM RESPONSE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RESPONSE; CIRCULATORY DEPRESSION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GEL MOBILITY SHIFT ASSAY; HEART RATE; HYPOTENSION; LOSS OF FUNCTION MUTATION; MALE; MEDULLA OBLONGATA; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; ROSTRAL VENTROLATERAL MEDULLA; TRANSCRIPTION INITIATION; UPREGULATION; WESTERN BLOTTING; SIGNAL TRANSDUCTION;

IMPAIRMENT OF BRAIN STEM CARDIOVASCULAR REGULATION; MEVINPHOS INTOXICATION; NOS II/PEROXYNITRITE CASCADE; PI3K/AKT/NF-ΚB SIGNALING; ROSTRAL VENTROLATERAL MEDULLA;

ANIMALS; BLOOD CIRCULATION; BRAIN STEM; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; HYPOTENSION; INSECTICIDES; MALE; MEDULLA OBLONGATA; MEVINPHOS; MICROINJECTIONS; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SYMPATHETIC NERVOUS SYSTEM;

EID: 84896714163     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.01.014     Document Type: Article

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