Lipopolysaccharide activates Akt in vascular smooth muscle cells resulting in induction of inducible nitric oxide synthase through nuclear factor-kappa B activation

European Journal of Pharmacology

Volumn 481, Issue 2-3, 2003, Pages 153-158

  Hattori, Yoshiyuki ^a   Hattori, Sachiko ^a   Kasai, Kikuo ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Akt; iNOS; NF B; Vascular smooth muscle

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; GAMMA INTERFERON; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; WORTMANNIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA TRANSCRIPTION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

EID: 0345690083     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2003.09.034     Document Type: Article

References (23)

1. Baldwin A.S. Jr. NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 14:1996;649-683.
2. Bird T.A., Schooley K., Dower S.K., Hagen H., Virca G.D. Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit. J. Biol. Chem. 272:1997;32606-32612.
3. Bonnard M., Mirtsos C., Suzuki S., Graham K., Huang J., Ng M., Itie A., Wakeham A., Shahinian A., Henzel W.J., Elia A.J., Shillinglaw W., Mak T.W., Cao Z., Yeh W.C. Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. EMBO J. 19:2000;4976-4985.
4. Brazil D.P., Hemmings B.A. Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem. Sci. 26:2001;657-664.
5. Chamley-Campbell J., Campbell G.R., Ross R. The smooth muscle cell in culture. Physiol. Rev. 59:1979;1-61.
6. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
7. Eberhardt W., Kunz D., Pfeilschifer J. Pyrrolidine dithiocarbamate differentially affects interleukin 1β- and cAMP-induced nitric oxide synthase expression in rat mesangial cells. Biochem. Biophys. Res. Commun. 200:1994;163-170.
8. Gross S.S., Levi R. Tetrahydrobiopterin synthesis: an absolute requirement for cytokine induced nitric oxide generation by vascular smooth muscle. J. Biol. Chem. 267:1992;25722-25729.
9. Hattori Y., Gross S.S. GTP cyclohydrolase I mRNA is induced by LPS in vascular smooth muscle: characterization, sequence and relationship to nitric oxide synthase. Biochem. Biophys. Res. Commun. 195:1993;435-441.
10. Hattori Y., Hattori S., Kasai K. Troglitazone upregulates nitric oxide synthesis in vascular smooth muscle cells. Hypertension. 33:1999;943-948.
11. Hattori Y., Banba N., Gross S.S., Kasai K. Glycated serum albumin-induced nitric oxide production in vascular smooth muscle cells by nuclear factor κB-dependent transcriptional activation of inducible nitric oxide synthase. Biochem. Biophys. Res. Commun. 259:1999;128-132.
12. Hoeflich K.P., Luo J., Rubie E.A., Tsao M.S., Jin O., Woodgett J.R. Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature. 406:2000;86-90.
13. Huxford T., Malek S., Ghosh G. Structure and mechanism in NF-kappa B/I kappa B signaling. Cold Spring Harbor Symp. Quant. Biol. 64:1999;533-540.
14. Kandel E.S., Hay N. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp. Cell Res. 253:1999;210-229.
15. Karin M., Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-kappa B activity. Annu. Rev. Immunol. 18:2000;621-663.
16. Madrid L.V., Mayo M.W., Reuther J.Y., Baldwin A.S. Jr. Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. J. Biol. Chem. 276:2001;18934-18940.
17. Mulsch A., Schray-Utz B., Mordvibtcev P.I., Hauschildt S., Busse R. Diethyldithiocarbamate inhibits induction of macrophage NO synthase. FEBS Lett. 321:1993;215-218.
18. Scheid M.P., Woodgett J.R. PKB/AKT: functional insights from genetic models. Nat. Rev., Mol. Cell Biol. 2:2001;760-768.
19. Sherman M.P., Aeberhard E.E., Wong V.Z., Griscavage J.M., Ignarro L.J. Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages. Biochem. Biophys. Res. Commun. 191:1993;1301-1308.
20. Sizemore N., Leung S., Stark G.R. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. Mol. Cell. Biol. 19:1999;4798-4805.
21. Thomas K.W., Monick M.M., Staber J.M., Yarovinsky T., Carter A.B., Hunninghake G.W. Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway. J. Biol. Chem. 277:2002;492-501.
22. Wang D., Baldwin A.S. Jr. Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529. J. Biol. Chem. 273:1998;29411-29416.
23. Xie O., Kashiwabara Y., Nathan C. Role of transcription factor NF-kB/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269:1994;4705-4708.