TAK1-mediated induction of nitric oxide synthase gene expression in glial cells

Journal of Neurochemistry

Volumn 87, Issue 1, 2003, Pages 238-247

  Bhat, Narayan R ^a   Shen, Qin ^a   Fan, Fan ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Innate immunity; MAP kinase cascades; Microglia; Neuroinflammation; NF B; Signal transduction

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BINDING PROTEIN; CELL SURFACE RECEPTOR; CYTOKINE; ENZYME INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHOTRANSFERASE; SP 620125; SYNAPTOPHYSIN; TOLL LIKE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1 BINDING PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; BACTERIUM; CELL LINE; CONTROLLED STUDY; ENZYME INDUCTION; GENE EXPRESSION; GENETIC TRANSCRIPTION; GLIA CELL; IMMUNITY; IMMUNOREGULATION; INFLAMMATORY CELL; MICROGLIA; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; VIRUS;

ANIMALS; ASTROCYTES; CARRIER PROTEINS; ENZYME INDUCTION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MICROGLIA; NEUROGLIA; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROMOTER REGIONS (GENETICS); RATS; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANSFECTION;

ANIMALIA; BACTERIA (MICROORGANISMS); JANUS;

EID: 0141754194     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01998.x     Document Type: Article

References (41)

1. Alexander C. and Rietschel E. T. (2001) Bacterial lipopolysaccharides and innate immunity. J. Endotoxin Res. 7, 167-202.
2. Bhat N. R. and Fan F. (2002) Adenovirus infection induces microglial activation: involvement of mitogen-activated protein kinase pathways. Brain Res. 948, 93-101.
3. Bhat N. R. and Zhang P. (1994) Inhibitors of N-linked oligosaccharide processing glucosidases interfere with oligodendrocyte differentiation in culture. J. Neurosci. Res. 39, 1-10.
4. Bhat N. R., Zhang P., Lee J. C. and Hogan E. L. (1998) Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-α gene expression in endotoxin-stimulated primary glial cultures. J. Neurosci. 18, 1633-1641.
5. Bhat N. R., Feinstein D. L., Shen Q. and Bhat A. N. (2002) p38 MAPK-mediated transcriptional activation of inducible nitric oxide synthase in glial cells: roles of nuclear factors, NFκB, CREB, C/EBP and ATF-2. J. Biol. Chem. 277, 29584-29592.
6. Boutros M. and Agaisse H. (2002) Sequential activation of signaling pathways during innate immune responses in drosophila. Dev. Cell 3, 711-722.
7. Bsibsi M., Ravid R., Gveric D. and van Noort J. M. (2002) Broad expression of Toll-like receptors in the human central nervous system. J. Neuropathol. Exp. Neurol. 61, 1013-1021.
8. Cheepsunthorn P., Radov L., Menzies S., Reid J. and Connor J. R. (2001) Characterization of a novel brain-derived microglial cell line isolated from neonatal rat brain. Glia 35, 53-62.
9. Dong C., Davis R. J. and Flavell R. A. (2002) MAP kinases in the immune response. Annu. Rev. Immunol. 20, 55-72.
10. Ghosh S. and Karin M. (2002) Missing pieces in the NFκB puzzle. Cell 109, S81-S96.
11. Guan Z., Buckman S. Y., Springer L. D. and Morrison A. R. (1999) Both p38 alpha (MAPK) and JNK/SAPK pathways are important for induction of nitric-oxide synthase by interleukin-1 beta in rat glomerular mesangial cells. J. Biol. Chem. 274, 36200-36206.
12. Guha M. and Mackman N. (2001) LPS induction of gene expression in human monocytes. Cell Signaling 13, 85-94.
13. Han Z. Q. S., Enslen H., Hu X. D., Meng X. J., Wu I. H., Barrett T., Davis R. J. and Ip Y. T. (1998) A conserved p38 mitogen-activated protein kinase pathway regulates drosophila immunity gene expression. Mol. Cell Biol. 18, 3527-3539.
14. Irie T., Muta T. and Takeshige K. (2002) TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-kappa B in lipopolysaccharide-stimulated macrophages. FEBS Lett. 467, 160-164.
15. Ishitani T., Ninomiya-Tsuji J., Nagai S.-I., Nishita M., Meneghini M., Barker N., Waterman M., Bowerman B., Clevers H., Shibuya H. and Matsumoto K. (1999) The TAK1-NLK-MAPK-related pathway antagonizes signaling between β-catenin and transcription factor TCF. Nature 399, 798-802.
16. Janeway C. A. Jr and Medzhitov R. (2002) Innate immune recognition. Annu. Rev. Immunol. 20, 197-216.
17. Karin M. and Delhase M. (2000) The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signaling. Sem. Immunol. 12, 85-98.
18. Kim D. H., Feinbaum R., Alloing G., Emerson F. E., Garsin D. A., Inoue H., Tanaka-Hino M., Hisamoto N., Matsumoto K., Tan M. W. and Ausubel F. M. (2002) A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science 297, 623-626.
19. Koistinaho M. and Koistinaho J. (2002) Role of p38 and p44/42 mitogen-activated protein kinases in microglia. Glia 40, 175-183.
20. Kracht M. and Saklatvala J. (2002) Transcriptional and post-transcriptional control of gene expression in inflammation. Cytokine 20, 2002.
21. Kyriakis J. M. and Avruch J. (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81, 807-869.
22. Lee J., Mira-Arbibe L. and Ulevitch R. J. (2000) TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide. J. Leuk. Biol. 68, 909-915.
23. Li Q. T. and Verma I. M. (2002) NFκB regulation in the immune system. Nature Rev. Immunol. 2, 725-734.
24. Makarov S. S. (2000) NF-κB as a therapeutic target in chronic inflammation: recent advances. Mol. Med. Today 6, 441-448.
25. Mizukami J., Takaesu G., Akatsuka H., Sakurai H., Ninomiya-Tsuji J., Matsumoto K. and Sakurai N. (2002) Receptor activator of NF-kappa B ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol. Cell Biol. 22, 992-1000.
26. Natarajan K., Singh S., Burke T. R. Jr, Grunberger D. and Aggarwal B. B. (1996) Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-κB. Proc. Natl Acad. Sci. USA 93, 9090-9095.
27. Ninomiya-Tsuji J., Kishimoto K., Hiyama A., Inoue J., Cao Z. and Matsumoto K. (1999) The kinase TAK1 can activate NIK-IkappaB as well as the MAP kinase cascade in the IL-1 signaling pathway. Nature 398, 252-256.
28. Ozato K., Tsujimura H. and Tamura T. (2002) Toll-like receptor signaling and regulation of cytokine gene expression in the immune system. Biotechniques 33, S66-S75.
29. Sakurai H., Miyoshi H., Toriumi W. and Sugita T. (1999) Functional interactions of transforming growth factor β-activated kinase 1 with IκB kinases to stimulate NFκB activation. J. Biol. Chem. 274, 10641-10648.
30. Sakurai H., Nishi A., Sato N., Mizukami J., Miyoshi H. and Sugita T. (2002) TAK1-TAB1 fusion protein: a novel constitutively active mitogen-actiyated protein kinase kinase kinase that stimulates AP-1 and NFκB signaling pathways. Biochem. Biophys. Res. Commun. 297, 1277-1281.
31. Shibuya H., Yamaguchi K., Shirakabe K., Tonegawa A., Gotoh Y., Ueno N., Irie K., Nishida E. and Matsumoto K. (1996) TAB1 - an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science 272, 1179-1182.
32. Shibuya H., Iwata H., Masuyama N., Gotoh Y., Yamaguchi K., Irie K., Matsumoto K., Nishida E. and Ueno N. (1998) Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. EMBO J. 17, 1019-1028.
33. Shirakabe K., Yamaguchi K.; Shibuya H., Irie K., Matsuda S., Moriguchi T., Gotoh Y., Matsumoto K. and Nishida E. (1997) TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase. J. Biol. Chem. 272, 8141-8144.
34. Shuto T., Xu H., Wang B., Han J., Kai H., Gu X.-X., Murphy T. F., Lim D. J. and Li J.-D. (2001) Activation of NF-κB by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKKα/β-IκBα and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells. Proc. Natl Acad. Sci. 98, 8774-8779.
35. Takaesu G., Kishida S., Hiyama A., Yamaguchi K., Shibuya H., Irie K., Ninomiya-Tsuji J. and Matsumoto K. (2000) TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol. Cell 5, 649-658.
36. Takeda K., Kaisho T. and Akira S. (2003) Toll-like receptors. Ann. Rev. Immunol. 21, 335-376.
37. Vidal S., Khush R. S., Leulier F., Tzou P., Nakamura M. and Lemaitre B. (2001) Mutations in the Drosophila dTAK1 gene reveal a conserved function or MAPKKKs in the control of rel/NF-kappa B-dependent innate immune responses. Genes Dev. 15, 1900-1912.
38. Wald D., Commane M., Stark G. R. and Li X. (2001) IRAK and TAK1 are required for IL-18-mediated signaling. Eur. J. Immunol. 31, 3747-3754.
39. Wang C., Deng L., Hong M., Akkaraju G. R., Inoue J.-I. and Chen Z. J. (2001) TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346-351.
40. Yamaguchi K., Shirakabe K., Shibuya H., Irie K., Oishi I., Ueno N., Taniguchi T., Nishida E. and Matsumoto K. (1995) Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 270, 2008-2011.
41. Zekki H., Feinstein D. L. and Rivest S. (2002) The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS. Brain Pathol. 12, 308-319.