Sign epistasis limits evolutionary trade-offs at the confluence of single- and multi-carbon metabolism in Methylobacterium extorquens AM1

Evolution

Volumn 68, Issue 3, 2014, Pages 760-771

  Carroll, Sean Michael ^a   Lee, Ming Chun ^a,b   Marx, Christopher J ^a,c  

^a HARVARD UNIVERSITY   (United States)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c HARVARD UNIVERSITY   (United States)

Author keywords

Antagonistic pleiotropy; Ecological specialization; Experimental evolution; Formate tetrahydrofolate ligase; Loss of function; Methylotrophy

Indexed keywords

BACTERIUM; CARBON; ENZYME ACTIVITY; EPISTASIS; FITNESS; METABOLISM; METHANOL; METHYLATION; MUTATION; PLEIOTROPY; SPECIALIZATION; SUBSTRATE; TRADE-OFF;

METHYLOBACTERIUM EXTORQUENS;

BACTERIAL PROTEIN; CARBON; FORMATE TETRAHYDROFOLATE LIGASE; METHANOL; SUCCINIC ACID;

ANTAGONISTIC PLEIOTROPY; ARTICLE; ECOLOGICAL SPECIALIZATION; ENZYMOLOGY; EPISTASIS; EXPERIMENTAL EVOLUTION; GENETICS; LOSS OF FUNCTION; METABOLISM; METHYLOBACTERIUM EXTORQUENS; METHYLOTROPHY; MOLECULAR EVOLUTION; PHENOTYPE; PLEIOTROPY;

ANTAGONISTIC PLEIOTROPY; ECOLOGICAL SPECIALIZATION; EXPERIMENTAL EVOLUTION; FORMATE-TETRAHYDROFOLATE LIGASE; LOSS OF FUNCTION; METHYLOTROPHY;

BACTERIAL PROTEINS; CARBON; EPISTASIS, GENETIC; EVOLUTION, MOLECULAR; FORMATE-TETRAHYDROFOLATE LIGASE; GENETIC PLEIOTROPY; METHANOL; METHYLOBACTERIUM EXTORQUENS; PHENOTYPE; SUCCINIC ACID;

EID: 84896702264     PISSN: 00143820     EISSN: 15585646     Source Type: Journal    
DOI: 10.1111/evo.12301     Document Type: Article

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