Mechanism of N 10-formyltetrahydrofolate synthetase derived from complexes with intermediates and inhibitors

Protein Science

Volumn 21, Issue 2, 2012, Pages 219-228

  Celeste, Lesa R ^a   Chai, Geqing ^a   Bielak, Magdalena ^a   Minor, Wladek ^b   Lovelace, Leslie L ^a   Lebioda, Lukasz ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Folate enzymes; Formylphosphate; Formyltetrahydrofolate synthetase; Ligase; Ping pong mechanism

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALANINE; ARGININE; FOLIC ACID; FOLINIC ACID; FORMATE TETRAHYDROFOLATE LIGASE; ION; NITROGEN; NUCLEOSIDE; PHOSPHATE; PLEVITREXED; PTERIN; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; FORMYL PHOSPHATE; LIGAND; MULTIPROTEIN COMPLEX; ORGANOPHOSPHORUS COMPOUND; QUINAZOLINE DERIVATIVE;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CONFORMATION; DISSOCIATION; HYDROGEN BOND; MOORELLA THERMOACETICA; NUCLEOPHILICITY; PRIORITY JOURNAL; STRUCTURE ANALYSIS; BINDING COMPETITION; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; KINETICS; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE;

MOORELLA THERMOACETICA;

ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; CATALYSIS; ENZYME INHIBITORS; FORMATE-TETRAHYDROFOLATE LIGASE; KINETICS; LIGANDS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; ORGANOPHOSPHORUS COMPOUNDS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; QUINAZOLINES;

EID: 84856208484     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2005     Document Type: Article

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