A 3D structural model and dynamics of hepatitis C virus NS3/4A protease (genotype 4a, strain ED43) suggest conformational instability of the catalytic triad: Implications in catalysis and drug resistivity

Journal of Biomolecular Structure and Dynamics

Volumn 32, Issue 6, 2014, Pages 950-958

  Rimmert, Bradley ^a   Sabet, Salwa ^b   Ackad, Edward ^a   Yousef, Mohammad S ^a,b  

^a SOUTHERN ILLINOIS UNIVERSITY EDWARDSVILLE   (United States)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

catalysis; dynamics; genotype 4; HCV; structure

Indexed keywords

ASPARTIC ACID; BOCEPREVIR; HISTIDINE; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4; SERINE; TELAPREVIR; NS3 PROTEIN, HEPATITIS C VIRUS; VIRUS PROTEIN;

ANTIVIRAL RESISTANCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; GENE SEQUENCE; HEPATITIS C VIRUS GENOTYPE 4; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STABILITY; VIRUS GENE; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; GENOTYPE; HEPATITIS C; HUMAN; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE;

HEPATITIS C VIRUS;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; DRUG RESISTANCE, VIRAL; GENOTYPE; HEPATITIS C; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84896691986     PISSN: 07391102     EISSN: 15380254     Source Type: Journal    
DOI: 10.1080/07391102.2013.800001     Document Type: Article

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