Correlations of the basicity of His 57 with transition state analogue binding, substrate reactivity, and the strength of the low-barrier hydrogen bond in chymotrypsin

Biochemistry

Volumn 37, Issue 34, 1998, Pages 11940-11948

  Lin, Jing ^a   Cassidy, Constance S ^a   Frey, Perry A ^a  

^a UNIVERSITY OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHYMOTRYPSIN;

ALKALINITY; ARTICLE; CONFORMATIONAL TRANSITION; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; ASPARAGINE; BINDING SITES; CATALYSIS; CATTLE; CHYMOTRYPSIN; DIPEPTIDES; ENZYME ACTIVATION; HISTIDINE; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; KETONES; KINETICS; MACROMOLECULAR SUBSTANCES; MAGNETIC RESONANCE SPECTROSCOPY; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TEMPERATURE;

FELIS CATUS;

EID: 0032566351     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980278s     Document Type: Article

References (32)

1. Imperiali, B., and Abeles, R. H. (1986) Biochemistry 25, 3760-3767.
2. Brady, K., and Abeles, R. H. (1990) Biochemistry 29, 7608-7617.
3. Liang, T.-C., and Abeles, R. H. (1987) Biochemistry 26, 7603-7608.
4. Frey, P. A., Whitt, S. A., and Tobin, J. B. (1994) Science 264, 1927-1930.
5. Cassidy, C. S., Lin, J. L., and Frey, P. A. (1997) Biochemistry 36, 4576-4584.
6. Kraut, J. (1971) Annu. Rev. Biochem. 46, 331-358.
7. Bergeson, S. H., Edwards, P. D., Shweartz, J. A., Shaw, A., Square, K., Stein, M. M., Trainor, D. A., Mills, G., Wildonger, R. A., and Wolanin, D. J. (1990) U.S. Patent 4,910,190.
8. Hore, P. J. (1983) J. Magn. Reson. 55, 283-300.
9. Zhong, S., Haghjoo, K., Kettner, C., and Jordan, F. (1995) J. Am. Chem. Soc. 117, 7048-7055.
10. Bruice, T. C., Fife, T. H., Bruno, J. J., and Brandon, N. E. (1962) Biochemistry 1, 7-12.
11. Himoe, A., Parks, P. C., and Hess, G. P. (1967) J. Biol. Chem. 242, 919-929.
12. Fersht, A. R., and Requena, Y. (1971) J. Mol. Biol. 60, 279-290.
13. McDermott, A., and Ridenour, C. F. (1996) in Encyclopedia of NMR, pp 3820-3824, Wiley and Sons, Ltd., Sussex, England.
14. Pan, Y., and McAllister, M. A. (1997) J. Am. Chem. Soc. 119, 7561-7566.
15. Hibbert, F., and Emsley, J. (1990) Adv. Phys. Org. Chem. 26, 255-379.
16. Brady, K., Wei, A., Ringe, D., and Abeles, R. H. (1990) Biochemistry 29, 7600-7607.
17. Robillard, G., and Shulman, R. G. (1974) J. Mol. Biol. 86, 519-540.
18. Markley, J. L. (1978) Biochemistry 17, 4648-4656.
19. Ash, E. L., Sudmeier, J. L., DeFabo, E. C., and Bachovchin, W. W. (1997) Science 278, 1128-1131.
20. Bone, R., Shenvi, A. B., Kettner, C. A., and Agard, D. A. (1987) Biochemistry 26, 7609-7614.
21. Halkides, C. J., Wu, Y. Q., and Murray, C. J. (1996) Biochemistry 35, 15941-15948.
22. Smirnov, S. N., Golubev, N. S., Denisov, G. S., Benedict, H., Schah-Mohammedi, P., and Limbach, H.-H. (1996) J. Am. Chem. Soc. 118, 4094-4101.
23. Cotton, F. A., and Wilkinson, G. (1962) Advanced Inorganic Chemistry, pp 85-95, Wiley and Sons, New York.
24. Kerr, J. A. (1966) Chem. Rev. 66, 465-500.
25. Pilcher, G., and Skinner, H. A. (1982) in The Chemistry of the Metal-Carbon Bond (Hartley, F. R., and Patai, S., Eds.) Chapter 2, pp 43-90, Wiley and Sons, New York.
26. Cassidy, C. S. (1997) Ph.D. Dissertation, University of Wisconsin-Madison, Madison, WI.
27. Markley, J. L., and Westler, W. M. (1996) Biochemistry 35, 11092-11097.
28. Dixon, M. M., Brennan, R. G., and Matthews, B. W. (1991) Int. J. Biol. Macromol. 13, 89-96.
29. Dixon, M. M., and Matthews, B. W. (1989) Biochemistry 28, 7033-7038.
30. Gerlt, J. A., Kreevoy, M. M., Cleland, W. W., and Frey, P. A. (1997) Chem. Biol. 4, 259-267.
31. Zhao, Q., Abeygunawardana, C., Gittis, A. G., and Mildvan, A. S. (1997) Biochemistry 36, 14616-14626.
32. Kim, S. W., Cha, S.-S., Cho, H.-S., Kim, J.-S., Ha, N.-C., Cho, M.-J., Joo, S., Kim, K. K., Choi, K. Y., and Oh, B.-H. (1997) Biochemistry 36, 14030-14036.