Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA

Journal of the American Chemical Society

Volumn 133, Issue 21, 2011, Pages 8078-8081

  Barriuso, Jorge ^a   Nguyen, Don T ^a   Li, Jesse W H ^b   Roberts, Joseph N ^a   MacNevin, Gillian ^a   Chaytor, Jennifer L ^b   Marcus, Sandra L ^b   Vederas, John C ^b   Ro, Dae Kyun ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ASPERGILLUS TERREUS; BIOCHEMICAL ANALYSIS; CODON OPTIMIZATION; CYTOCHROME P450; CYTOCHROME P450 GENES; ENZYME ASSAYS; IN-VITRO; IN-VIVO; LOVASTATIN; MONOOXYGENASES; N-TERMINALS; OXIDATIVE REACTION; POLYKETIDE SYNTHASES; RECOMBINANT ENZYMES; SACCHAROMYCES CEREVISIAE; SIMVASTATIN;

BIOCHEMISTRY; BIOSYNTHESIS; CATALYSIS; GENES; HYDROXYLATION; YEAST;

ENZYMES;

CYTOCHROME P450; CYTOCHROME P450 OXYGENASE; LOVASTATIN A; LOVASTATIN B; LOVASTATIN C; LOVASTATIN D; LOVASTATIN F; MEVINOLIN; MONACOLIN J; MONACOLIN L; POLYKETIDE SYNTHASE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL BOND; CODON; DRUG HYDROXYLATION; DRUG OXIDATION; DRUG SYNTHESIS; ENZYME ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEOTIDE SEQUENCE; OXIDATION KINETICS; PROTEIN EXPRESSION; STEREOCHEMISTRY;

ASPERGILLUS; CYTOCHROME P-450 ENZYME SYSTEM; LOVASTATIN; NAPHTHALENES; OXIDATION-REDUCTION; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE;

EID: 79957753066     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja201138v     Document Type: Article

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