The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 12, 1997, Pages 6099-6103

  Sin, Ny ^a   Meng, Lihao ^a   Wang, Margaret Q W ^a   Wen, James J ^a   Bornmann, William G ^b   Crews, Craig M ^a  

^a YALE UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; ANGIOGENESIS INHIBITOR; BIOTIN; DRUG BINDING PROTEIN; FUMAGILLIN; FUMAGILLOL CHLOROACETYLCARBAMATE; METALLOPROTEINASE; METHIONINE;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; COVALENT BOND; CYTOSTASIS; DRUG MECHANISM; DRUG POTENCY; ENDOTHELIUM CELL; ENZYME INHIBITION; FUNGUS GROWTH; HUMAN; HUMAN CELL; METASTASIS INHIBITION; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; UMBILICAL VEIN;

AMINO ACID SEQUENCE; AMINOPEPTIDASES; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BINDING SITES; CATTLE; CYCLOHEXANES; FATTY ACIDS, UNSATURATED; HUMANS; KINETICS; MAMMALS; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; NEOVASCULARIZATION, PATHOLOGIC; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SESQUITERPENES;

EID: 0030924753     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.12.6099     Document Type: Article

References (29)

1. Folkman, J. (1974) Adv. Cancer Res. 19, 331-358.
2. Brem, H., Gresser, I., Grosfeld, J. & Folkman, J. (1993) J. Pediatr. Surg. 28, 1253-1257.
3. Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S. & Ferrara, N. (1993) Nature (London) 362, 841-844.
4. Fidler, I.J. & Ellis, L. M. (1994) Cell 79, 185-188.
5. Folkman, J. & Ingber, D. (1992) Semin. Cancer Biol. 3, 89-96.
6. Auerbach, W. & Auerbach, R. (1994) Pharmacol. Ther. 63, 265-311.
7. O'Reilly, M. S., Brem, H. & Folkman, J. (1995) J. Pediatr. Surg. 30, 325-329.
8. Takamiya, Y., Brem, H., Ojeifo, J., Mineta, T. & Martuza, R. L. (1994) Neurosurgery 34, 869-875.
9. Wilson, J. T. & Penar, P. L. (1994) Neurol. Res. 16, 121-124.
10. Yamaoka, M., Yamamoto, T., Ikeyama, S., Sudo, K. & Fujita, T. (1993) Cancer Res. 53, 5233-5236.
11. Abe, J., Zhou, W., Takuwa, N., Taguchi, J., Kurokawa, K., Kumada, M. & Takuwa, Y. (1994) Cancer Res. 54, 3407-3412.
12. Landquist, J. K. (1956) J. Chem. Soc. 1956, 4237-4245.
13. Taunton, J., Hassig, C. A. & Schreiber, S. L. (1996) Science 272, 408-411.
14. Marui, S. & Kishimoto, S. (1992) Chem. Pharmacol. Bull. 40, 575-579.
15. Ray, M. K., Chakraborty, A., Datta, B., Chattopadhyay, A., Saha, D., Bose, A., Kinzy, T. G., Wu, S., Hileman, R. E., Merrick, W. C. & Gupta, N. K. (1993) Biochemistry 32, 5151-5159.
16. Arfin, S. M., Kendall, R. L., Hall, L., Weaver, L. H., Stewart, A. E., Matthews, B. W. & Bradshaw, R. A. (1995) Proc. Natl. Acad. Sci. USA 92, 7714-7718.
17. Wu, S., Gupta, S., Chatterjee, N., Hileman, R. E., Kinzy, T. G., Denslow, N. D., Merrick, W. C., Chakrabarti, D., Osterman, J. C. & Gupta, N. K. (1993) J. Biol. Chem. 268, 10796-10801.
18. Kendall, R. L. & Bradshaw, R. A. (1992) J. Biol. Chem. 267, 20667-20673.
19. Keeling, P. J. & Doolittle, W. F. (1996) Trends Biochem. Sci. 21, 285-286.
20. Li, X. & Chang, Y.-H. (1995) Proc. Natl. Acad. Sci. USA 92, 12357-12361.
21. Ray, M. K., Datta, B., Chakraborty, A., Chattopadhyay, A., Meza-Keuthen, S. & Gupta, N. K. (1992) Proc. Natl. Acad. Sci. USA 89, 539-543.
22. Datta, B., Chakrabarti, D., Roy, A. & Gupta, N. K. (1988) Proc. Natl. Acad. Sci. USA 85, 3324-3328.
23. Wu, S., Rehemtulla, A., Gupta, N. K. & Kaufmann, R. J. (1996) Biochemistry 35, 8275-8280.
24. Budson, A. E., Ko, L., Brasel, C. & Bischoff, J. (1996) Biochem. Biophys. Res. Commun. 225, 141-145.
25. Li, X. & Chang, Y.-H. (1995) Biochim. Biophys. Acta 1260, 333-336.
26. Kusaka, M., Sudo, K., Matsutani, E., Kozai, Y., Marui, S., Fujita, T., Ingber, D. & Folkman, J. (1994) Br. J. Cancer 69, 212-216.
27. Yang, Z. & Wensel, T. G. (1992) J. Biol. Chem. 267, 23197-23201.
28. Peseckis, S. M., Deichaite, I. & Resh, M. D. (1993) J. Biol. Chem. 268, 5107-5114.
29. Bachmair, A., Finley, D. & Varshavsky, A. (1986) Science 234, 179-186.-