PESIN multimerization improves receptor avidities and in vivo tumor targeting properties to GRPR-overexpressing tumors

Bioconjugate Chemistry

Volumn 25, Issue 3, 2014, Pages 489-500

  Lindner, Simon ^a   Michler, Christina ^a   Wängler, Björn ^b   Bartenstein, Peter ^a   Fischer, Gabriel ^a,b   Schirrmacher, Ralf ^c   Wängler, Carmen ^a,b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; LIGANDS; MONOMERS; POSITRON EMISSION TOMOGRAPHY; TUMORS;

BINDING AFFINITIES; BIVALENT LIGANDS; IN-VIVO; MULTIMERIZATION; MULTIMERS; PEPTIDE RECEPTOR; TUMOR IMAGING; TUMOR TO BACKGROUND RATIOS; TUMOR UPTAKE; TUMOR-TARGETING;

PEPTIDES;

1,4,7 TRIAZACYCLONONANE 1 GLUTARIC ACID 4,7 DIACETIC ACID; BOMBESIN; CHELATING AGENT; DENDRIMER; GALLIUM 68; GASTRIN RELEASING PEPTIDE RECEPTOR; LIGAND; MONOMER; PEPTIDE DERIVATIVE; PESIN PEPTIDE; PESIN TETRAXETAN GALLIUM GA 68; POLYMER; RADIOPHARMACEUTICAL AGENT; TETRAXETAN; UNCLASSIFIED DRUG; BOMBESIN RECEPTOR; GALLIUM; OLIGOPEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CARCINOMA CELL; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DISTRIBUTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MOLECULARLY TARGETED THERAPY; MOUSE; NEOPLASM; NONHUMAN; PEPTIDE SYNTHESIS; PHARMACOLOGICAL PARAMETERS; POLYMERIZATION; POSITRON EMISSION TOMOGRAPHY; PROSTATE CARCINOMA; PROTEIN BINDING; PROTEIN CROSS LINKING; TUMOR XENOGRAFT; ANIMAL; BIOSYNTHESIS; CHEMISTRY; CONFORMATION; DIAGNOSTIC USE; METABOLISM; NEOPLASMS, EXPERIMENTAL; NUDE MOUSE; SCID MOUSE; SYNTHESIS; TUMOR CELL CULTURE;

ANIMALS; GALLIUM RADIOISOTOPES; HUMANS; LIGANDS; MICE; MICE, NUDE; MICE, SCID; MOLECULAR CONFORMATION; NEOPLASMS, EXPERIMENTAL; OLIGOPEPTIDES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RECEPTORS, BOMBESIN; TUMOR CELLS, CULTURED;

EID: 84896530448     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc4004662     Document Type: Article

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