Synthesis, 18F-labeling, and in vitro and in vivo studies of bombesin peptides modified with silicon-based building blocks

Bioconjugate Chemistry

Volumn 19, Issue 9, 2008, Pages 1871-1879

  Höhne, Aileen ^a   Mu, Linjing ^a   Honer, Michael ^a   Schubiger, P August ^a   Ametamey, Simon M ^a   Graham, Keith ^b   Stellfeld, Timo ^b   Borkowski, Sandra ^b   Berndorff, Dietmar ^b   Klar, Ulrich ^b   Voigtmann, Ulrike ^b   Cyr, John E ^b   Friebe, Matthias ^b   Dinkelborg, Ludger ^b   Srinivasan, Ananth ^b  

^a ETH ZURICH   (Switzerland)

^b BAYER PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; IMAGE PROCESSING; SILICON; SYNTHESIS (CHEMICAL); TUMORS;

BOMBESIN ANALOGUES; BUILDING BLOCKES; HUMAN TUMORS; IN-VITRO; LABELINGS; PEPTIDE RECEPTOR; PET IMAGING; RADIOLABELLING; SILICON-BASED; VITRO AND IN VIVO STUDIES;

PEPTIDES;

BOMBESIN; FLUORINE 18; GASTRIN RELEASING PEPTIDE RECEPTOR; SILICON; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; BOMBESIN RECEPTOR; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FLUORINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPROTECTION REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MASS SPECTROMETRY; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; POSITRON EMISSION TOMOGRAPHY; PROSTATE TUMOR; PROTEIN STABILITY; PROTEIN STRUCTURE; RADIOISOTOPE DISTRIBUTION; RECEPTOR BINDING; SOLID PHASE SYNTHESIS; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; ENZYME SPECIFICITY; HUMAN; MALE; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; PATHOLOGY; SYNTHESIS;

AMINO ACID SEQUENCE; BINDING SITES; BOMBESIN; FLUORINE RADIOISOTOPES; HUMANS; ISOTOPE LABELING; MALE; MOLECULAR SEQUENCE DATA; NEUROTRANSMITTER AGENTS; POSITRON-EMISSION TOMOGRAPHY; PROSTATIC NEOPLASMS; RECEPTORS, BOMBESIN; SILICON; SUBSTRATE SPECIFICITY;

EID: 52249113335     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc800157h     Document Type: Article

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