Preclinical evaluation of a novel 111in-labeled bombesin homodimer for improved imaging of GRPR-positive prostate cancer

Molecular Pharmaceutics

Volumn 10, Issue 5, 2013, Pages 1716-1724

  Carlucci, G ^a   Ananias, H J K ^a   Yu, Z ^a   Hoving, H D ^a   Helfrich, W ^a   Dierckx, R A J O ^a,c   Liu, S ^a   De Jong, I J ^a   Elsinga, P H ^a,b  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c PURDUE UNIVERSITY   (United States)

Author keywords

bombesin homodimer; GRPR; PC 3 tumor model; prostate cancer imaging

Indexed keywords

DOTA NHS IN 111; GASTRIN RELEASING PEPTIDE RECEPTOR; HOMODIMER; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; 1,4,7,10-TETRAAZACYCLODODECANE- 1,4,7,10-TETRAACETIC ACID; BOMBESIN; BOMBESIN RECEPTOR; INDIUM; SINGLE HETEROCYCLIC RINGS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG BINDING; DRUG DISTRIBUTION; DRUG STABILITY; DRUG UPTAKE; EVALUATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INCUBATION TIME; MALE; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN TARGETING; PURIFICATION; RADIOACTIVITY; SCID MOUSE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TUMOR XENOGRAFT; ANIMAL; DIAGNOSTIC USE; EVALUATION STUDY; METABOLISM; NUDE MOUSE; PROSTATE TUMOR; SCINTISCANNING; TUMOR CELL LINE;

ANIMALS; BOMBESIN; CELL LINE, TUMOR; HETEROCYCLIC COMPOUNDS, 1-RING; HUMANS; INDIUM RADIOISOTOPES; MALE; MICE; MICE, NUDE; PROSTATIC NEOPLASMS; RADIOPHARMACEUTICALS; RECEPTORS, BOMBESIN; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84877305896     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp3005462     Document Type: Article

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