Development of a potent DOTA-conjugated bombesin antagonist for targeting GRPr-positive tumours

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 38, Issue 1, 2011, Pages 97-107

  Mansi, Rosalba ^a,d   Wang, Xuejuan ^a   Forrer, Flavio ^a,e   Waser, Beatrice ^b   Cescato, Renzo ^b   Graham, Keith ^c   Borkowski, Sandra ^c   Reubi, Jean Claude ^b   Maecke, Helmut R ^a,d  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c BAYER PHARMA AG   (Germany)

^d UNIVERSITY OF FREIBURG   (Germany)

^e ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Bombesin; Gallium 68; Gastrin releasing peptide receptor; Indium 111; Prostate cancer

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID 4 AMINO 1 CARBOXYMETHYL PIPERIDINE DEXTRO PHENYLALANYLGLUTAMINYLTRYPTOPHANYLALANYLVALYLGLYCYLHISTIDYL SOMASTATIN LEUCINE AMIDE; BOMBESIN; BOMBESIN ANTAGONIST; CALCIUM ION; GALLIUM 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID 4 AMINO 1 CARBOXYMETHYL PIPERIDINE DEXTRO PHENYLALANYLGLUTAMINYLTRYPTOPHANYLALANYLVALYLGLYCYLHISTIDYL SOMASTATIN LEUCINE AMIDE GA 68; GALLIUM 68; GASTRIN RELEASING PEPTIDE RECEPTOR; INDIUM 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID 4 AMINO 1 CARBOXYMETHYL PIPERIDINE DEXTRO PHENYLALANYLGLUTAMINYLTRYPTOPHANYLALANYLVALYLGLYCYLHISTIDYL SOMASTATIN LEUCINE AMIDE IN 111; INDIUM 111; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CALCIUM MOBILIZATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; IMMUNOFLUORESCENCE; IN VITRO STUDY; INTERNALIZATION; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; PANCREAS; POSITRON EMISSION TOMOGRAPHY; PROSTATE CANCER; PROTEIN TARGETING; RADIOISOTOPE DISTRIBUTION; RADIOISOTOPE THERAPY;

ANIMALS; BOMBESIN; CELL LINE, TUMOR; DRUG DISCOVERY; FEMALE; HEK293 CELLS; HETEROCYCLIC COMPOUNDS, 1-RING; HUMANS; MALE; MICE; OLIGOPEPTIDES; PROSTATIC NEOPLASMS; PROTEIN TRANSPORT; RECEPTORS, BOMBESIN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79551537113     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-010-1596-9     Document Type: Article

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