A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: Preparation, antibacterial activity and toxicity evaluation

Journal of Materials Science: Materials in Medicine

Volumn 21, Issue 8, 2010, Pages 2435-2442

  Ji, Qiu Xia ^a   Zhao, Qing Sheng ^b,c   Deng, Jing ^a   Lü, Rui ^a  

^a QINGDAO UNIVERSITY   (China)

^b INSTITUTE OF PROCESS ENGINEERING   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE TOXICITY; ANTI-BACTERIAL ACTIVITY; AQUEOUS SOLUTIONS; ARTIFICIAL SALIVA; CHLORHEXIDINE; CROSS-LINKED NETWORKS; GLYCEROPHOSPHATE; IN-VITRO; INHIBITORY ACTIVITY; LOCAL DRUG DELIVERY; MAXIMUM TOLERATED DOSE; RELEASE RATE; SCAN ELECTRON MICROSCOPY; SEM; THERMO-SENSITIVE HYDROGEL;

DRUG DELIVERY; GELS; SOLUTIONS; TOXICITY;

HYDROGELS;

ALPHA,BETA GLYCEROPHOSPHATE; CHITOSAN; CHLORHEXIDINE; GLYCEROPHOSPHATE; SALIVA SUBSTITUTE; UNCLASSIFIED DRUG;

ACIDITY; ANTIBACTERIAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CROSS LINKING; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; FEMALE; HEAT SENSITIVITY; HYDROGEL; IN VITRO STUDY; INHIBITION KINETICS; MALE; MOUSE; NONHUMAN; PERIODONTICS; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; TOXICITY TESTING;

ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; CHLORHEXIDINE; DRUG CARRIERS; DRUG STABILITY; FEMALE; HYDROGEL; INJECTIONS; MALE; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, BIOLOGICAL; PERIODONTAL DISEASES; RATS; TEMPERATURE; TOXICITY TESTS;

RATTUS;

EID: 77956418146     PISSN: 09574530     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10856-010-4098-1     Document Type: Article

References (34)

1. SJ Janket AE Baird SK Chuang JA Jones 2003 Meta-analysis of periodontal disease and risk of coronary heart disease and stroke Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95 559 569 10.1067/moe.2003.107 12738947 (Pubitemid 36886703)
2. S Offenbacher V Katz G Fertik J Collins D Boyd G Maynor R McKaig J Beck 1996 Periodontal infection as a possible risk factor for preterm low birth weight J Periodontol 67 1103 1113 1:STN:280:DyaK2s%2FmslCitA%3D%3D 8910829
3. Walker CB. The acquisition of antibiotic resistance in the periodontal microflora. Periodontol 2000. 1996;10:79-88.
4. AJ van Winkelhoff D Herrera Gonzales EG Winkel N Dellemijn-Kippuw CM Vandenbroucke-Grauls M Sanz 2000 Antimicrobial resistance in the subgingival microflora in patients with adult periodontitis. A comparison between The Netherlands and Spain J Clin Periodontol 27 79 86 10.1034/j.1600-051x.2000. 027002079.x 10703651
5. G De Lissovoy AM Rentz EM Dukes CA Eaton MK Jeffcoat WJ Killoy RD Finkelman 1999 The cost-effectiveness of a new chlorhexidine delivery system in the treatment of adult periodontitis J Am Dent Assoc 130 855 862 10377645
6. M Paolantonio G Perinetti S D'Ercole F Graziani G Catamo G Sammartino R Piccolomini 2008 Internal decontamination of dental implants: an in vivo randomized microbiologic 6-month trial on the effects of a chlorhexidine gel J Periodontol 79 1419 1425 10.1902/jop.2008.070660 1:CAS:528:DC%2BD1cXhtVClu7nO 18672991
7. WA Soskolne T Chajek M Flashner I Landau A Stabholtz B Kolatch EI Lerner 1998 An in vivo study of the chlorhexidine release profile of the PerioChip in the gingival crevicular fluid, plasma and urine J Clin Periodontol 25 1017 1021 10.1111/j.1600-051X.1998.tb02407.x 1:CAS:528:DyaK1cXotV2lur0%3D 9869352
8. AJ McBain RG Bartolo CE Catrenich D Charbonneau RG Ledder P Gilbert 2003 Effects of a chlorhexidine gluconate-containing mouthwash on the vitality and antimicrobial susceptibility of in vitro oral bacterial ecosystems Appl Environ Microbiol 69 4770 4776 10.1128/AEM.69.8.4770-4776.2003 1:CAS:528: DC%2BD3sXmsFWrtL8%3D 12902270 (Pubitemid 36992940)
9. S Senel G Ikinci S Kas A Yousefi-Rad MF Sargon AA Hincal 2000 Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery Int J Pharm 193 197 203 10.1016/S0378-5173(99)00334-8 1:CAS:528:DyaK1MXnvFSltrY%3D 10606782 (Pubitemid 30001862)
10. ES Ron LE Bromberg 1998 Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery Adv Drug Deliv Rev 31 197 221 10.1016/S0169-409X(97)00121-X 10837626 (Pubitemid 28191866)
11. C Gong S Shi P Dong B Kan M Gou X Wang X Li F Luo X Zhao Y Wei Z Qian 2009 Synthesis and characterization of PEG-PCL-PEG thermosensitive hydrogel Int J Pharm 365 89 99 10.1016/j.ijpharm.2008.08.027 1:CAS:528:DC%2BD1cXhsVKnurzK 18793709
12. CB Liu CY Gong MJ Huang JW Wang YF Pan YD Zhang GZ Li ML Gou K Wang MJ Tu YQ Wei ZY Qian 2008 Thermoreversible gel-sol behavior of biodegradable PCL-PEG-PCL triblock copolymer in aqueous solutions J Biomed Mater Res B Appl Biomater 84 165 175 17455282
13. CY Gong S Shi PW Dong XL Zheng SZ Fu G Guo JL Yang YQ Wei ZY Qian 2009 In vitro drug release behavior from a novel thermosensitive composite hydrogel based on Pluronic f127 and poly(ethylene glycol)-poly(epsilon-caprolactone)- poly(ethylene glycol) copolymer BMC Biotechnol 9 8 10.1186/1472-6750-9-8 19210779
14. CB Liu CY Gong ZY Qian 2007 Synthesis and characterization of a thermosensitive hydrogel based on biodegradable amphiphilic PCLPluronic(L35)-PCL block copolymer Colloid Surf Part A 302 430 438 10.1016/j.colsurfa.2007.03.006 1:CAS:528:DC%2BD2sXltF2rsrc%3D (Pubitemid 46719915)
15. GL Southard KC Godowski 1998 Subgingival controlled release of antimicrobial agents in the treatment of periodontal disease Int J Antimicrob Agents 9 239 253 10.1016/S0924-8579(98)00004-1 1:CAS:528:DyaK1cXislSltL4%3D 9573494 (Pubitemid 28152354)
16. LC Wang XG Chen DY Zhong QC Xu 2007 Study on poly(vinyl alcohol)/carboxymethyl-chitosan blend film as local drug delivery system J Mater Sci Mater Med 18 1125 1133 10.1007/s10856-007-0159-5 1:CAS:528: DC%2BD2sXlsVCjsrk%3D 17268861 (Pubitemid 46795231)
17. SH Lim SM Hudson 2004 Synthesis and antimicrobial activity of a water-soluble chitosan derivative with a fiber-reactive group Carbohydr Res 339 313 319 10.1016/j.carres.2003.10.024 1:CAS:528:DC%2BD3sXhtVWhu7vE 14698889 (Pubitemid 38041136)
18. Y Xu Y Du R Huang L Gao 2003 Preparation and modification of N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride nanoparticle as a protein carrier Biomaterials 24 5015 5022 10.1016/S0142-9612(03)00408-3 1:CAS:528:DC%2BD3sXotVSjs7g%3D 14559015 (Pubitemid 37237631)
19. I Milazzo G Blandino F Caccamo R Musumeci G Nicoletti A Speciale 2003 Faropenem, a new oral penem: antibacterial activity against selected anaerobic and fastidious periodontal isolates J Antimicrob Chemother 51 721 725 10.1093/jac/dkg120 1:CAS:528:DC%2BD3sXit12lt74%3D 12615878 (Pubitemid 36336170)
20. XG Chen L Zheng Z Wang CY Lee HJ Park 2002 Molecular affinity and permeability of different molecular weight chitosan membranes J Agric Food Chem 50 5915 5918 10.1021/jf020151g 1:CAS:528:DC%2BD38XmvFWltLc%3D 12358459 (Pubitemid 35155314)
21. QX Ji XG Chen QS Zhao CS Liu XJ Cheng LC Wang 2009 Injectable thermosensitive hydrogel based on chitosan and quaternized chitosan and the biomedical properties J Mater Sci Mater Med 20 1603 1610 10.1007/s10856-009- 3729-x 1:CAS:528:DC%2BD1MXos1egsrs%3D 19322644
22. YM Chung KL Simmons A Gutowska B Jeong 2002 Sol-gel transition temperature of PLGA-g-PEG aqueous solutions Biomacromolecules 3 511 516 10.1021/bm0156431 1:CAS:528:DC%2BD38XitlOks7s%3D 12005522 (Pubitemid 34567454)
23. A Chenite C Chaput D Wang C Combes MD Buschmann CD Hoemann JC Leroux BL Atkinson F Binette A Selmani 2000 Novel injectable neutral solutions of chitosan form biodegradable gels in situ Biomaterials 21 2155 2161 10.1016/S0142- 9612(00)00116-2 1:CAS:528:DC%2BD3cXls1Cltb0%3D 10985488
24. J Wu W Wei LY Wang ZG Su GH Ma 2007 A thermosensitive hydrogel based on quaternized chitosan and poly(ethylene glycol) for nasal drug delivery system Biomaterials 28 2220 2232 10.1016/j.biomaterials.2006.12.024 1:CAS:528:DC%2BD2sXhsFCkurY%3D 17291582 (Pubitemid 46216447)
25. DW Paquette GS Waters VL Stefanidou HP Lawrence PM Friden SM O'Connor JD Sperati FG Oppenheim LH Hutchens RC Williams 1997 Inhibition of experimental gingivitis in beagle dogs with topical salivary histatins J Clin Periodontol 24 216 222 10.1111/j.1600-051X.1997.tb01834.x 1:CAS:528:DyaK2sXjtVaju7c%3D 9144043
26. T Nakagawa S Yamada Y Oosuka A Saito Y Hosaka T Ishikawa K Okuda 1991 Clinical and microbiological study of local minocycline delivery (Periocline) following scaling and root planing in recurrent periodontal pockets Bull Tokyo Dent Coll 32 63 70 1:STN:280:DyaK38zgs1ejsw%3D%3D 1819445
27. K Hayashi K Takada M Hirasawa 1998 Clinical and microbiological effects of controlled-release local delivery of minocycline on periodontitis in dogs Am J Vet Res 59 464 467 1:CAS:528:DyaK1cXivVShtbo%3D 9563632
28. MA Graca TL Watts RF Wilson RM Palmer 1997 A randomized controlled trial of a 2% minocycline gel as an adjunct to non-surgical periodontal treatment, using a design with multiple matching criteria J Clin Periodontol 24 249 253 10.1111/j.1600-051X.1997.tb01838.x 1:CAS:528:DyaK2sXjtVaisr8%3D 9144047
29. N Jain GK Jain S Javed Z Iqbal S Talegaonkar FJ Ahmad RK Khar 2008 Recent approaches for the treatment of periodontitis Drug Discov Today 13 932 943 10.1016/j.drudis.2008.07.010 1:CAS:528:DC%2BD1cXht12rs7%2FF 18789399
30. HM Eriksen H Nordbo H Kantanen JE Ellingsen 1985 Chemical plaque control and extrinsic tooth discoloration. A review of possible mechanisms J Clin Periodontol 12 345 350 10.1111/j.1600-051X.1985.tb00924.x 1:STN:280: DyaL2M3jsV2rsQ%3D%3D 3891794 (Pubitemid 15079757)
31. M Addy J Moran RM Davies A Beak A Lewis 1982 The effect of single morning and evening rinses of chlorhexidine on the development of tooth staining and plaque accumulation. A blind cross-over trial J Clin Periodontol 9 134 140 10.1111/j.1600-051X.1982.tb01229.x 1:STN:280:DyaL387ptVCrtw%3D%3D 6951838
32. MR Wirthlin PK Chen CI Hoover 2005 A laboratory model biofilm fermenter: design and initial trial on a single species biofilm J Periodontol 76 1443 1449 10.1902/jop.2005.76.9.1443 1:CAS:528:DC%2BD2MXhtFegtLrO 16171430 (Pubitemid 41479358)
33. S Eick T Seltmann W Pfister 2004 Efficacy of antibiotics to strains of periodontopathogenic bacteria within a single species biofilm-an in vitro study J Clin Periodontol 31 376 383 10.1111/j.0303-6979.2004.00490.x 1:CAS:528:DC%2BD2cXks1yht7s%3D 15086620 (Pubitemid 38624030)
34. Y Noiri Y Okami M Narimatsu Y Takahashi T Kawahara S Ebisu 2003 Effects of chlorhexidine, minocycline, and metronidazole on Porphyromonas gingivalis strain 381 in biofilms J Periodontol 74 1647 1651 10.1902/jop.2003.74.11.1647 1:CAS:528:DC%2BD2cXltVah 14682662 (Pubitemid 37540705)