Semisolid systems containing propolis for the treatment of periodontal disease: In vitro release kinetics, syringeability, rheological, textural, and mucoadhesive properties

Journal of Pharmaceutical Sciences

Volumn 96, Issue 8, 2007, Pages 2074-2089

  Bruschi, Marcos L ^a,d   Jones, David S ^b   Panzeri, Heitor ^a   Gremião, Maria P D ^c   De Freitas, Osvaldo ^a   Lara, Elza H G ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^d Câmpus Universitário ^*  (Brazil)

Author keywords

Biodegradable polymers; Buccal; Hydrogels; Injectables; Mechanical properties; Natural products; Oral drug delivery

Indexed keywords

C 934P; CARBOMER; P 407; POLOXAMER; PROPOLIS; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; HUMAN; OSCILLATION; PERIODONTAL DISEASE; PHYSICAL CHEMISTRY; SHEAR RATE; SHEAR STRESS; THIXOTROPY;

EID: 34548037865     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20843     Document Type: Article

References (62)

1. Listgarten MA. 1987. Nature of periodontal disease: Pathogenic mechanisms. J Periodontol Res 22:172-178.
2. Jones DS, Woolfson AD, Brown AF, O'Neill MJ. 1997. Mucoadhesive, syringeable drug delivery systems for controlled application of metronidazole to the periodontal pocket: In vitro release kinetics, syringeability, mechanical and mucoadhesive properties. J Control Rel 49:71-79.
3. Medlicott NJ, Rathbone MJ, Tucker IG, Holborow DW. 1994. Delivery systems for the administration of drugs to the periodontal pocket. Adv Drug Deliv Rev 13:181-203.
4. Slots J, Genco RJ. 1984. Black-pigmented Bacteroides species, Capnocytophaga species and Actinobacillus actinomycetem comitans in human periodontal disease: Virulence factors in colonisation, survival and tissue destruction. J Dental Res 63:412-421.
5. Lindhe J, Haffajee AJ, Socransky SS. 1983. Progression of periodontal disease in adult subjects in the absence of periodontal therapy. J Clin Periodontol 10:433-442.
6. Listgarten MA. 1986. Pathogenesis of periodontitis. J Clin Periodontol 13:418-425.
7. Wolff L, Dahlen G, Aeppli D. 1994. Bacteria as risk markers for Periodontitis. J Periodontol 64:498-510.
8. Jones DS, Irwin CR, Woolfson AD, Djokic J, Adams V. 1999. Physicochemical characterization and preliminary in vivo efficacy of bioadhesive, semi-solid formulations containing flurbiprofen for the treatment of gingivitis. J Pharm Sci 88:592-598.
9. Listgarten MA, Lindhe J, Hellden L. 1978. Effects of tetracycline and/or scaling on human periodontal disease. J Clin Periodontol 5:246-271.
10. Genco RJ. 1981. Antibiotics in the treatment of human periodontal diseases. J Periodontol 52:545-558.
11. Bruschi ML, Panzeri H, Lara EHG. 2005. Recent progress in research of propolis use in Periodontology. Rev ABO Nac 13:86-91.
12. Kujumgiev A, Tsvetkova I, Serkedjieva Y, Bankova V, Christov R, Popov S. 1999. Antibacterial, antifungal and antiviral activity of propolis of different geographic origin. J Ethnopharmacol 64:235-240.
13. Koo H, Gomes BPFA, Rosalen PL, Ambrosano GMB, Park YK, Cury JA. 2000. In vitro antimicrobial activity of propolis and Arnica montana against oral pathogens. Arch Oral Biol 45:141-148.
14. Santos FA, Bastos EMA, Uzeda M, Carvalho MAR, Farias LM, Moreira ESA, Braga FC. 2002. Antibacterial activity of Brazilian propolis and fractions against oral anaerobic bacteria. J Ethnopharmacol 80:1-7.
15. Santos FA, Bastos EMA, Rodrigues PH, Uzeda M, de Carvalho MAR, Farias LM, Moreira ESA. 2002. Susceptibility of Prevotella intermedia/Prevotella nigrescens (and Porphyromonas gingivalis) to propolis (bee glue) and other antimicrobial agents. Anaerobe 8:9-15.
16. Burdock GA. 1998. Review of the biological properties and toxicity of bee propolis (Propolis). Food Chem Toxicol 36:347-363.
17. Song YS, Park E, Hur GM, Ryu YS, Kim YM, Jin C. 2002. Ethanol extract of propolis inhibits nitric oxide synthase gene expression and enzyme activity. J Ethnopharmacol 80:155-161.
18. Marquele FD, Di Mambro VM, Georgetti SR, Casagrande R, Valim YML, Fonseca MJV. 2005. Assessment of the antioxidant activities of Brazilian extracts of propolis alone and in topical pharmaceutical formulations. J Pharm Biom Anal 39:455-462.
19. Holderna E, Kedzia B. 1987. Investigations upon the combined action of propolis and antimycotic drugs on Candida albicans. Herba Pol 33:145-151.
20. Goodson JM, Haffajee A, Socransky S. 1979. Periodontal therapy by local delivery of tetracycline. J Clin Periodontol 6:83-92.
21. Deasy PB, Collins AEM, MacCarthy DJ, Russell RJ. 1989. Use of strips containing tetracycline hydrochloride or metronidazole for the treatment of advanced periodontal disease. J Pharm Pharmacol 41:694-699.
22. Golomb G, Friedman M, Soskolne A, Stabholz A, Sela MN. 1984. Sustained release device containing metronidazole for periodontal use. J Dent Res 63:1149-1153.
23. Steinberg D, Friedman M, Soskolne A, Sela MN. 1990. A new degradable controlled release device for the treatment of periodontal disease: In vitro release study. J Periodontol 61:393-398.
24. Addy M, Rawle L, Handley R, Newman HN, Coventry JF. 1982. The development and in vitro evaluation of acrylic strips and dialysis tubing for local drug delivery. J Periodontol 53:693-699.
25. Agarwal RK, Robinson DH, Maze GI, Reinhardt RA. 1993. Development and characterisation of tetracycline-poly(lactide/glycolide) films for the treatment of Periodontitis. J Control Release 23:137-146.
26. Jones DS, Woolfson AD, Brown AF, Coulter WA, Mcclelland C, Irwin CR. 2000. Design, characterisation and preliminary clinical evaluation of a novel mucoadhesive topical formulation containing tetracycline for the treatment of periodontal disease. J Control Rel 67:357-368.
27. Kelly HM, Deasy PB, Ziaka E, Claffey N. 2004. Formulation and preliminary in vivo dog studies of a novel drug delivery system for the treatment of Periodontitis. Int J Pharm 274:167-183.
28. Jones DS, Woolfson AD, Djokic J, Coulter WA. 1996. Development and mechanical characterization of bioadhesive semi-solid, polymeric systems containing tetracycline for the treatment of periodontal diseases. Pharm Res 13:1734-1738.
29. Jones DS, Brown AF, Woolfson AD. 2001. Rheological characterization of bioadhesive, antimicrobial, semisolids designed for the treatment of periodontal diseases: Transient and dynamic viscoelastic and continuous shear analysis. J Pharm Sci 90:1978-1990.
30. Perioli L, Ambrogi V, Rubini D, Giovagnoli S, Ricci M, Blasi P, Rossi C. 2004. Novel mucoadhesive buccal formulation containing metronidazole for the treatment of periodontal disease. J Control Rel 95:521-533.
31. Bhardwaj R, Blanchard J. 1996. Controlled-release delivery system for the α-MSH analog melanotan-I using poloxamer 407. J Pharm Sci 85:915-919.
32. Esposito E, Cortesi R, Nastruzzi C. 1996. Gelatin microspheres: Influence of preparation parameters and thermal treatment on chemico-physical and biopharmaceutical properties. Biomaterials 17:2009-2020.
33. Bruschi ML, Cardoso MLC, Lucchesi MB, Gremião MPD. 2003. Gelatin microparticles containing propolis obtained by spray-drying technique: Preparation and characterization. Int J Pharm 264:45-55.
34. Choi H-G, Lee M-K, Kim M-H, Kim C-K. 1999. Effect of additives on the physicochemical properties of liquid suppository bases. Int J Pharm 190:13-19.
35. Nakamoto RY. 1979. Use of saliva substitute in post-radiation xerostomia. J Prosthetic Dent 42:539-542.
36. Bruschi ML, Franco SL, Gremião MPD. 2003. Application of an HPLC method for analysis of propolis extract. J Liq Chromatogr Rel Technol 26:2381-2391.
37. Malkin AYa. 1994. Fundamental topics in rheology: Rheology Fundamentals. Ontario: ChemTec Publishing.
38. Edsman K, Carlfors J, Petersson R. 1998. Rheological evaluation of poloxamer as an in situ gel for ophtalmic use. Eur J Pharm Sci 6:105-112.
39. Chang JY, Oh Y-K, Choi H-G, Kim Y-B, Kim C-K. 2002. Rheological evaluation of thermosensitive and mucoadhesive vaginal gels in physiological conditions. Int J Pharm 241:155-163.
40. Ricci EJ, Bentley MVLB, Farah M, Bretas RES, Marchetti JM. 2002. Rheological characterization of Poloxamer 407 lidocaine hydrochloride gels. Eur J Pharm Sci 17:161-167.
41. Tosh SM, Marangoni AG. 2004. Determination of the maximum gelation temperature in gelatin gels. App Phys Letters 84:4242-4244.
42. Jones DS, Woolfson AD, Brown AF. 1997. Textural, viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers. Int J Pharm 151:223-233.
43. Jones DS, Lawlor MS, Woolfson AD. 2002. Examination of the flow rheological and textural properties of polymer gels composed of poly (methylvinylether-co-maleic anhydride) and poly (vinylpyrrolidone): Rheological and mathematical interpretation of textural parameters. J Pharm Sci 91:2090-2101.
44. Jones DS. 2002. Pharmaceutical statistics. London: The Pharmaceutical Press.
45. Bruschi ML, de Freitas O. 2005. Oral bioadhesive drug delivery systems. Drug Dev Ind Pharm 31:293-310.
46. Bruschi ML, Martins CHG, Vinholis AHC, Casemiro LA, Panzeri H, Gremiao MPD, Lara EHG. 2006. Preparation and antimicrobial activity of gelatin microparticles containing propolis against oral pathogens. Drug Dev Ind Pharm 32:229-238.
47. Irwin CR, McCullough KC, Jones DS. 2003. Chlorhexidine-containing mucoadhesive polymeric compacts designed for use in the oral cavity: An examination of their physical properties, in vitro/in vivo drug release properties and clinical acceptability. J Mat Sci 14:825-832.
48. Woolfson AD, Malcon RK, McCarron PA, Jones DS. 2002. Bioadhesive drug delivery systems. In: Dumitriu S, editor. Polymeric biomaterials. New York: Marcel Dekker, pp 1063-1083.
49. Yun M-O, Choi H-G, Jung J-H, Kim C-K. 1999. Development of a termo-reversible insulin liquid suppository with bioavailability enhancement. Int J Pharm 189:137-145.
50. Schmolka I. 1972. Artificial skin I. Praparation and properties of Pluronic F-127 gels for treatment of burns. J Biomed Mater Res 6:571-582.
51. Varshosaz J, Dehghan Z. 2002. Development and characterization of buccoadhesive nifedipine tablets. Eur J Pharm Biopharm 54:135-141.
52. Soskolone WA, Freidman MF. 1996. Intra-periodontal pocket drug delivery systems. In: Rathbone MJ, editor. Oral mucosal drug delivery. New York: Marcel Dekker, pp 359-379.
53. Higuchi T. 1963. Mechanism of sustained-action medication: Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 52:1145-1149.
54. Ritger PL, Peppas NA. 1987. A simple equation for description of solute release. II. Fickian and anomalous release from swellable devices. J Control Rel 5:37-42.
55. Barreiro-Iglesias R, Alvarez-Lorenzo C, Concheiro A. 2003. Poly(acrylic acid) microgels (carbopol® 934)/surfactant interactions in aqueous media Part I: Nonionic surfactants. Int J Pharm 258:165-177.
56. Paavola A, Yliruusi J, Rosenberg P. 1998. Controlled release and dura mater permeability of lidocaine and ibuprofen from injectable poloxamer-based gels. J Control Rel 52:169-178.
57. Seymour RA, Heasman PA. 1992. Drugs, diseases, and the periodontum. New York: Oxford Medical Publications, Oxford University Press.
58. Clarke MT. 1993. Rheological additives. In: Labba D, editor. Rheological properties of cosmetics and toiletries. New York: Marcel Dekker, pp 152-155.
59. Shin S-C, Kim J-Y, Oh I-J. 2000. Mucoadhesive and physiochemical characterization of Carbopol-Poloxamer gels containing triamcinolone acetonide. Drug Dev Ind Pharm 26:307-312.
60. Barnes HA, Hutton JF, Walters K. 1989. An introduction to rheology, Vol. 3. Amsterdam: Elsevier.
61. Almdal K, Dyre J, Hvidt S, Kramer O. 1993. Towards a phenomenological definition of the term gel. Polym Gels Netw 1:5-17.
62. Tamburic S, Craig DQM. 1995. An investigation into the rheological dielectric and mucoadhesive properties of poly(acrylic acid) gel systems. J Control Rel 37:59-68.