Development and evaluation of novel biodegradable microspheres based on poly(d,l-lactide-co-glycolide) and poly(ε-caprolactone) for controlled delivery of doxycycline in the treatment of human periodontal pocket: In vitro and in vivo studies

Journal of Controlled Release

Volumn 119, Issue 1, 2007, Pages 59-68

  Mundargi, Raghavendra C ^a   Srirangarajan, S ^b   Agnihotri, Sunil A ^a   Patil, Sangamesh A ^a   Ravindra, S ^b   Setty, Swati B ^b   Aminabhavi, Tejraj M ^a  

^a KARNATAK UNIVERSITY   (India)

^b SDM COLLEGE OF DENTAL SCIENCES AND HOSPITAL   (India)

Author keywords

Blends; Doxycycline; Microspheres; PCL; Periodontal pocket; PLGA

Indexed keywords

BIODEGRADABLE POLYMERS; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY; DYNAMIC LIGHT SCATTERING; EMULSIONS; ENCAPSULATION; FOURIER TRANSFORM INFRARED SPECTROSCOPY; SCANNING ELECTRON MICROSCOPY;

DOUBLE EMULSION TECHNIQUE; DOXYCYCLINE; DYNAMIC LASER LIGHT SCATTERING; IN VIVO EFFICACY;

MICROSPHERES;

DOXYCYCLINE; MICROSPHERE; POLYCAPROLACTONE; POLYGLACTIN; POLYMER;

ARTICLE; BIODEGRADABILITY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; EMULSION; ENCAPSULATION; EVALUATION; GEL; GINGIVA; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MINIMUM INHIBITORY CONCENTRATION; NORMAL HUMAN; PARTICLE SIZE; PERIODONTITIS; PH; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY;

DOXYCYCLINE; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; HUMANS; LACTIC ACID; MICROSPHERES; PERIODONTAL POCKET; POLYESTERS; POLYGLYCOLIC ACID; POLYMERS; RANDOM ALLOCATION;

EID: 34147133304     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.01.008     Document Type: Article

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