Adjunctive effect of chlorhexidine antiseptics in mechanical periodontal treatment: First results of a preliminary case series

International Journal of Dental Hygiene

Volumn 11, Issue 3, 2013, Pages 180-185

  Calderini, A ^a   Pantaleo, G ^a,b   Rossi, A ^a   Gazzolo, D ^a   Polizzi, E ^a  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Chlorhexidine; Instrumentation; Micro organism; Periodontitis

Indexed keywords

CHLORHEXIDINE; CHLORHEXIDINE GLUCONATE; DRUG DERIVATIVE; TOPICAL ANTIINFECTIVE AGENT;

ADJUVANT CHEMOTHERAPY; ADULT; AGGREGATIBACTER ACTINOMYCETEMCOMITANS; ARTICLE; BACTEROIDES; CHEMISTRY; CHRONIC PERIODONTITIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EQUIPMENT; HUMAN; MICRO-ORGANISM; MICROBIOLOGY; MIDDLE AGED; NONPARAMETRIC TEST; PERIODONTICS; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; PREVENTIVE DENTISTRY; RANDOMIZED CONTROLLED TRIAL; TOOTH PLAQUE; TREPONEMA DENTICOLA;

CHLORHEXIDINE; INSTRUMENTATION; MICRO-ORGANISM; PERIODONTITIS;

ADULT; AGGREGATIBACTER ACTINOMYCETEMCOMITANS; ANTI-INFECTIVE AGENTS, LOCAL; BACTEROIDES; CHEMOTHERAPY, ADJUVANT; CHLORHEXIDINE; CHRONIC PERIODONTITIS; DENTAL PLAQUE; DENTAL SCALING; DOUBLE-BLIND METHOD; HUMANS; MIDDLE AGED; PERIODONTAL INDEX; PORPHYROMONAS GINGIVALIS; STATISTICS, NONPARAMETRIC; TREPONEMA DENTICOLA;

EID: 84880095550     PISSN: 16015029     EISSN: 16015037     Source Type: Journal    
DOI: 10.1111/idh.12009     Document Type: Article

References (39)

1. Loe H, Theilade E, Jensen SB. Experimental gingivitis in man. J Periodontol 1965; 36: 177-187.
2. Sanz M, van Winkelhoff AJ, Working Group 1 of Seventh European Workshop on Periodontology. Periodontal infections: understanding the complexity-consensus of the Seventh European Workshop on Periodontology. J Clin Periodontol 2011; 38(Suppl 11): 3-6.
3. Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000 1994; 5: 78-111.
4. Socransky SS, Haffajee AD. Dental biofilms: difficult therapeutic targets. Periodontol 2000 2002; 28: 12-55.
5. Ximenez-Fyvie LA, Haffajee AD, Socransky SS. Comparison of the microbiota of supra- and subgingival plaque in subjects in health and periodontitis. J Clin Periodontol 2000; 27: 648-657.
6. Preshaw PM, Seymour RA, Heasman PA. Current concepts in periodontal pathogenesis. Dent Update 2004; 31: 570-572, 574-578, Review.
7. Greenstein G. Nonsurgical periodontal therapy in 2000: a literature review. J Am Dent Assoc 2000; 131: 1580-1592.
8. Van der Weijden GA, Timmerman MF. A systematic review on the clinical efficacy of subgingival debridement in the treatment of chronic periodontitis. J Clin Periodontol 2002; 29(Suppl 3): 55-71.
9. Tunkel J, Heinecke A, Flemmig TF. A systematic review of efficacy of machine-driven and manual subgingival debridement in the treatment of chronic periodontitis. J Clin Periodontol 2002; 29(Suppl 3): 72-81.
10. Eberhard J, Jepsen S, Jervøe-Storm PM, Needleman I, Worthington HV. Full-mouth disinfection for the treatment of adult chronic periodontitis. Cochrane Database Syst Rev 2008; 23: CD004622.
11. Hellstrom MK, Ramberg P, Krok I, Lindhe J. The effect of supragingival plaque control on the subgingival microbiota in subjects with periodontal disease. J Clin Periodontal 1992; 19: 802-809.
12. Petersilka GJ, Ehmke B, Flemmig TF. Antimicrobial effects of mechanical debridement. Periodontol 2000 2002; 28: 56-71. Review.
13. Hallmon W, Rees TD. Local antiinfective therapy: mechanical and physical approaches. A systematic review. Ann Periodontol 2003; 8: 99-114.
14. Hanes PJ, Purvis JP. Local anti-infective therapy: pharmacological agents. A systematic review. Ann Periodontol 2003; 8: 79-98.
15. Cosyn J, Wyn I. A systematic review on the effects of the chlorhexidine chip when used as an adjunct to scaling and root planing in the treatment of chronic periodontitis. J Periodontol 2006; 77: 257-264.
16. Puig Silla M, Montiel Company JM, Almerich Silla JM. Use of chlorhexidine varnishes in preventing and treating periodontal disease. A review of the literature. Med Oral Patol Oral Cir Bucal 2008; 13: 257-260.
17. Jones CG. Clorhexidine: is still the gold standard? In: Addy M, Moran JM, eds. Toothpaste, Mouth Rinse and Other Topical Remedies in Periodontics. Periodontol 2000 1997; 15: 55-62.
18. Berchier CE, Slot DE, Van der Weijden GA. The efficacy of 0.12 chlorhexidine mouthrinse compared with 0.12 on plaque accumulation and periodontal parameters: a systematic review. J Clin Periodontol 2010; 37: 829-839.
19. Lindhe J, Lang NP, Karring T. Clinical Periodontology and Implant Dentistry, 5th edn. Copenaghen, Blackwell Munksgaard: Blackwell Ed, 2008.
20. Braatz L, Garrett S, Claffey N, Egelberg J. Antimicrobial irrigation of deep pockets to supplement nonsurgical periodontal therapy. II. Daily irrigation. J Clin Periodontol 1985; 12: 630-638.
21. Langer R. New methods of drug delivery. Science 1990; 249: 1527-1533.
22. Paolantonio M, D'Angelo M, Grassi RF et al. Clinical and microbiologic effects of subgingival controlled-release delivery of chlorhexidine chip in the treatment of periodontitis: a multicenter study. J Periodontol 2008; 79: 271-282.
23. Guarnelli ME, Franceschetti G, Manfrini R, Trombelli L. Adjunctive effect of chlorhexidine in ultrasonic instrumentation of aggressive periodontitis patients: a pilot study. J Clin Periodontol 2008; 35: 333-341.
24. Apatzidou DA, Kinane DF. Quadrant root planing versus same-day full mouth root planing.I. Clinical findings. J Clin Periodontol 2004; 31: 132-140.
25. Tonetti MS, Lang NP, Cortellini P et al. Effects of a single topical doxycycline administration adjunctive to mechanical debridement in patients with persistent/recurrent periodontitis but acceptable oral hygiene during supportive periodontal therapy. J Clin Periodontol 2012; 39: 475-482.
26. Lang NP, Tan WC, Krähenmann MA, Zwahlen M. A systematic review of the effects of full-mouth debridement with and without antiseptics in patients with chronic periodontitis. J Clin Periodontol 2008; 35(8 Suppl): 8-21.
27. Bollen CML, Quirynen M. Microbiological response to mechanical treatment in combination with adjunctive therapy. A review of the literature. J Periodontol 1996; 67: 1143-1158.
28. Haffajee AD, Cugini MA, Dibart S, Smith C, Kent RL, Socransky SS. The effect of SRP on the clinical and microbiological parameters of periodontal disease. J Clin Periodontol 1997; 24: 324-334.
29. Cugini MA, Haffajee AD, Smith C, Kent RL Jr, Socransky SS. The effect of scaling and root planing on the clinical and microbiological parameters of periodontal diseases: 12-month results J Clin Periodontol 2000; 27: 30-36.
30. Apatzidou DA, Riggio MP, Kinane DF. Quadrant root planing versus same-day full mouth root planing. II. microbiological findings. J Clin Periodontol 2004; 31: 141-148.
31. Pantaleo G. Criteri per l'elaborazione di un lavoro scientifico [Guidelines for planning and conducting scientific research]. Ital Oral Surg 2012; 2: 47-58.
32. Cosyn J, Sabzevar MM. Subgingival chlorhexidine varnish administration as an adjunct to same-day full-mouth root planing. II. Microbiological observations. J Periodontol 2007; 78: 438-445.
33. Gonzales JR, Harnack L, Schmitt-Corsitto G et al. A novel approach to the use of subgingival controlled-release chlorhexidine delivery in chronic periodontitis: a randomized clinical trial. J Periodontol 2011; 82: 1131-1139.
34. Quirynen M, Bollen CML, Vandekerkhove BNA, Dekeyser C, Papaioannou W, Eyssen H. Full-vs. Partial-mouth disinfection in the treatment of periodontal infections: short-term clinical and microbiological observations. J Dent Res 1995; 74: 1459-1467.
35. Bollen CML, Mongardini C, Papaioannou W, van Steenberghe D, Quirynen M. The effect of a one-stage full-mouth disinfection on different intra-oral niches. Clinical and microbiological observation. J Clin Periodontol 1998; 25: 56-66.
36. Guarnelli ME, Zangari F, Manfrini R, Scapoli C, Trombelli L. Evaluation of amine fluoride/stannous fluoride-containing mouthrinse during supportive therapy in patients with generalized aggressive periodontitis. A randomized, crossover, double-blind, controlled trial. J Clin Periodontol 2004; 31: 742-748.
37. Gupta R, Pandit N, Aggarwal S, Verma A. Comparative evaluation of subgingivally delivered 10% doxycycline hyclate and xanthan-based chlorhexidine gels in the treatment of chronic periodontitis. J Contemp Dent Pract 2008; 9: 25-32.
38. Matesanz P, Herrera D, Echeverria A, O'Connor A, Gonzalez I, Sanz M. A randomized clinical trial and microbiological efficacy of a xanthan gel with chlorhexidine for subgengival use. Clin Oral Investig 2012; 16: 25-31.
39. Paolantonio M, D'Ercole S, Pilloni A et al. Clinical, microbiologic, and biochemical effects of subgingival administration of a Xanthan-based chlorhexidine gel in the treatment of periodontitis: a randomized multicenter trial. J Periodontol 2009; 80: 1479-1492.