Periodontal delivery of ipriflavone: New chitosan/PLGA film delivery system for a lipophilic drug

International Journal of Pharmaceutics

Volumn 252, Issue 1-2, 2003, Pages 1-9

  Perugini, P ^a   Genta, I ^a   Conti, B ^a   Modena, T ^a   Pavanetto, F ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

Chitosan; Ipriflavone; Periodontal delivery; PLGA; Polymeric films

Indexed keywords

CHITOSAN; IPRIFLAVONE; POLYGLACTIN; POLYMER;

ALKALINITY; ARTICLE; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG DOSE REGIMEN; DRUG RELEASE; DRUG STRUCTURE; DRUG SYNTHESIS; EMULSION; ENZYME ACTIVITY; EVAPORATION; IONIC STRENGTH; MORPHOLOGY; PERIODONTITIS; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE; WATER ABSORPTION;

CHITIN; CHITOSAN; DRUG DELIVERY SYSTEMS; ISOFLAVONES; LACTIC ACID; LIPIDS; PERIODONTAL POCKET; POLYGLYCOLIC ACID; POLYMERS; SOLUBILITY;

EID: 0037452407     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00602-6     Document Type: Article

References (17)

1. Gogoleski S., Mainil-Varlet P. Effect of thermal treatment on sterility, molecular and mechanical properties of various polylactides. Biomaterials. 18:1997;251-255.
2. Head K.A. Ipriflavone: An important bone-building isoflavone. Altern. Med. Rev. 4:1999;10-22.
3. Lee J.-Y., Nam S.-H., Im S.-Y., Park Y.-J., Lee Y.-M., Seol Y.-J., Chung C.-P., Lee S.-J. Enhanced bone formation by controlled growth factor delivery from chitosan-based biomaterials. J. Control. Release. 78:2002;187-197.
4. Martini M., Formigli L., Tonelli P., Giannelli M., Alunni F., Naldi D., Brandi M.L., Zecchi Orlandini S., Orlandini G.E. Effects of ipriflavone on perialveolar bone formation. Calcif. Tissue Int. 63:1998;312-319.
5. Moss J.M., Van Damme M.P., Murphy W.H., Stanton P.G., Thomas P., Preston B.N. Purification, characterization, and biosynthesis of bovine cartilage lysozyme isoforms. Arch. Biochem. Biophys. 339:1997;172-182.
6. Muzzarelli, R.A.A., 1997. Depolymerization of chitins and chitosans with hemicellulase, lysozyme, papain and lipases. In: Muzzarelli, R.A.A., Martin, G.P. (Eds.), Chitin Handbook. Atec, Grottammare, pp. 153-163.
7. Muzzarelli R.A.A. The colorimetric determination of chitosan. Anal. Biochem. 260:1998;255-257.
8. Muzzarelli R.A.A., Mattioli-Belmonte M., Tietz C., Biagini R., Ferioli G., Brunelli M.A., Fini M., Giardino R., Ilari P., Biagini G. Stimulatory effect on bone formation exerted by a modified chitosan. Biomaterials. 15:1994;1075-1081.
9. Needleman I.G., Smales F.C. In vitro assessment of bioadhesion for periodontal and buccal drug delivery. Biomaterials. 16:1995;617-624.
10. Needleman I.G., Smales F.C., Martin G.P. An investigation of bioadhesion for periodontal and oral mucosal drug delivery. J. Clin. Periodontol. 24:1997;394-400.
11. Pavanetto F., Perugini P., Conti B., Modena T., Genta I. Evaluation of process parameters involved in chitosan microsphere preparation by the o/w/o multiple emulsion method. J. Microencapsul. 13:1996;679-688.
12. Senel S., Ikinci G., Kas S., Yousefi-Rad A., Sargon M.F., Hincal A.A. Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery. Int. J. Pharm. 193:2000;197-203.
13. Senel, S., Kas, H.S., Squier, C.A., 2000a. Application of chitosan in dental drug delivery and therapy. In: Muzzarelli, R.A.A. (Ed.), Chitosan Per Os From Dietary Supplement to Drug Carrier. Atec, Grottammare, pp. 241-256.
14. Shu X.Z., Zhu K.J., Song W. Novel pH-sensitive citrate cross-linked chitosan film for drug controlled release. Int. J. Pharm. 212:2001;19-28.
15. Soskolone, W.A., Freidman, M., 1996. Intra-periodontal pocket drug delivery systems. In: Rathbone, M.G. (Ed.), Drugs and the Pharmaceutical Sciences, vol. 74. Oral Mucosal Drug Delivery. Dekker (Marcel), New York, pp. 359-379.
16. Steinberg D., Friedman M. Dental drug-delivery devices: Local and sustained-release applications. Crit. Rev. Ther. Drug Carrier Syst. 16:1999;425-459.
17. Merck Manual, 1999. The Merck Manual of diagnosis and therapy. In: Beers, M.H., Berkow, R. (Eds.), Teeth and Periodontium, 7th ed (Section 9, Chapter 106).