Studies on development of controlled delivery of combination drug(s) to periodontal pocket

Indian Journal of Dental Research

Volumn 21, Issue 1, 2010, Pages 72-83

  Tiwari, Gaurav ^a   Tiwari, Ruchi ^b   Rai, Awani K ^b  

^a JAIPUR NATIONAL UNIVERSITY   (India)

^b PRANVEER SINGH INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Bioadhesive polymers; Controlled release; Doxycycline; Metronidazole; Periodontal diseases

Indexed keywords

DOXYCYCLINE; METRONIDAZOLE; TOPICAL ANTIINFECTIVE AGENT;

ADHESION; ARTICLE; BIOMECHANICS; CHEMISTRY; COMPRESSIVE STRENGTH; DELAYED RELEASE FORMULATION; DENTAL CARE; DRUG COMBINATION; DRUG DESIGN; DRUG EFFECT; ESCHERICHIA COLI; FLOW KINETICS; GEL; HARDNESS; MATERIALS TESTING; MICROBIOLOGICAL EXAMINATION; PERIODONTAL POCKET; PORPHYROMONAS GINGIVALIS; STAPHYLOCOCCUS AUREUS;

ADHESIVENESS; ANTI-INFECTIVE AGENTS, LOCAL; BIOMECHANICS; COMPRESSIVE STRENGTH; DELAYED-ACTION PREPARATIONS; DENTAL STRESS ANALYSIS; DOXYCYCLINE; DRUG COMBINATIONS; DRUG DESIGN; ESCHERICHIA COLI; GELS; HARDNESS; MATERIALS TESTING; METRONIDAZOLE; MICROBIAL SENSITIVITY TESTS; PERIODONTAL POCKET; PORPHYROMONAS GINGIVALIS; RHEOLOGY; STAPHYLOCOCCUS AUREUS;

EID: 77952212812     PISSN: 09709290     EISSN: 19983603     Source Type: Journal    
DOI: 10.4103/0970-9290.62814     Document Type: Article

References (23)

1. Annals of Periodontology. World Workshop in Periodontics, Chicago, American Academy of Periodontology 1996;1:1.
2. Slots J, Bragd L, Wikström M, Dahlén G. The occurrence of Actinobacillus actinomycetemcomitans, Bacteroides gingivalis and Bacteroides intermedius in destructive periodontal disease in adults. J Clin Periodontol 1986;13:570-577
3. Dzink JL, Tanner AC, Haffajee AD, Socransky SS. Gram negative species associated with active destructive periodontal lesions. J Clin Periodontol 1985;12:648-659
4. Rams TE, Slots J. Local delivery of antimicrobial agents in the periodontal pocket. Periodontol 1996;10:139-159
5. Greenstein G. Effects of subgingival irrigation on periodontal status. J Periodontol 1991;63:118-130
6. Carranza, Newman GM, Fermim AC. Clinical Periodontol. Saunders; 2004:815-817
7. Rosevear FB. The microscopy of the liquid crystalline neat and middle phases of soaps and synthetic detergents. J Am Oil Chem Soc 1954;13:628.
8. Miller SC, Donovan MD. Effect of poloxamer 407 gel on the miotic activity of pilocarpine nitrate in rabbits. Int J Pharm 1982;12:147-152
9. Jones DS, Woolfson AD, Djokic J, Coulter WA. Development and mechanical characterisation of bioadhesive semi-solid, polymeric systems containing tetracycline for the treatment of periodontal diseases. Pharm Res 1996;25:23-26
10. Vennat B, Gross D, Pourrat A. Procyanidin gels based on cellulose and carrageen derivatives. Drug Dev Ind Pharm 1992;18:1535-1548
11. Chein, Y. Transdermal controlled systemic medication, Marcel Dekker, New York, (1984).
12. Gurny R, Doelker E, Peppas NA. Modelling of sustained release of water-soluble drugs from porous, hydrophobic polymers. Biomaterials 1982;3:27-32.
13. Umesh V. Pharmaceutical dissolution testing, Marcel Dekker: New York; 1992.
14. Kaewsrichan J, Douglas CW, Nissen-Meyer J, Fimland G, Teanpaisan R. Characterization of a bacteriocin produced by Prevotella nigrescens ATCC 25261. Lett Appl Microbiol 2004;39:451.
15. Koo H, Gomes BP, Rosalen PL, Ambrosano GM, Park YK, Cury JA. In vitro antimicrobial activity of propolis and Arnicamontana against oral pathogens. Arch Oral Biol 2000;45:141-148
16. Javadpour MM, Juban MM, Lo WC, Bishop SM, Alberty JB, Cowell SM, et al. De novo antimicrobial peptides with low mammalian cell toxicity. J Med Chem 1996;39:3107-3113
17. Cabana A, Ait-kadi A, Juhasz J. Study of the gelation process of polyethylene oxide-polypropylene oxide-polyethylene oxide copolymer (poloxamer 407) aqueous solution. J Colloid Interface Sci 1997;190:312.
18. Song MJ, Lee DS, Ahn JH, Kim DJ, Kim SC. Dielectric behavior during solgel transition of PEO-PPO-PEO triblock copolymer aqueous solution. Polymer Bulletin 2000;43:497-504.
19. Bohorquez M, Koch C, Trygstad T, Pandit N. A study of the temperature-dependent micellization of pluronic F127. J Colloid Interface Sci 1999;216:34-40.
20. Esposito E, Carotta V, Scabbia A. Comparative analysis of tetra cycline-containing dental gels: Poloxamer- and monoglyceridebased formulations. Int J Pharm 1996;142:9-23.
21. Jones DS, Woolfson AD, Djokic J. Texture profile analysis of bioadhesive polymeric semisolids: Mechanical characterisation and investigation of interactions between formulation components. J Appl Polym Sci 1996;16:2229-2234
22. Peppas NA, Buri PA. Surface interfacial and molecular aspects of polymer bioadhesion on soft tissues. J Control Rel 1985;2:257-275
23. Gandhi RB, Robinson JR. Oral cavity as a site of bioadhesive drug delivery. Adv Drug Deliv Rev 1994;13:43-74.