Ethylcellulose inserts of an orphan drug for periodontitis: Preparation, in vitro, and clinical studies

Drug Delivery

Volumn 14, Issue 8, 2007, Pages 531-538

  Barat, Romi ^a   Srinatha, Anegundha ^a   Pandit, Jayantha K ^a,c   Mittal, Neelam ^b   Anupurba, Shampa ^b  

^a BANARAS HINDU UNIVERSITY   (India)

^b BANARAS HINDU UNIVERSITY   (India)

^c BANARAS HINDU UNIVERSITY   (India)

Author keywords

Casting Method; Ethyl Cellulose; Inserts; Niridazole; Periodontitis

Indexed keywords

ETHYL CELLULOSE; NIRIDAZOLE; ORPHAN DRUG;

ADULT; ARTICLE; BACTERIAL COUNT; BLEEDING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG MANUFACTURE; DRUG RELEASE; DRUG SOLUBILITY; DRUG SYNTHESIS; FEMALE; GINGIVA; HUMAN; IN VITRO STUDY; MALE; PERIODONTITIS; PRIORITY JOURNAL; TOOTH PLAQUE;

ADOLESCENT; ADULT; BIOLOGICAL AVAILABILITY; CELLULOSE; DELAYED-ACTION PREPARATIONS; DENTAL CALCULUS; DENTAL PLAQUE; DRUG DELIVERY SYSTEMS; FEMALE; FOLLOW-UP STUDIES; HEMORRHAGE; HUMANS; MALE; MIDDLE AGED; NIRIDAZOLE; ORPHAN DRUG PRODUCTION; PERIODONTAL DISEASES; PERIODONTAL INDEX; PERIODONTAL POCKET; PERIODONTITIS; PILOT PROJECTS; SINGLE-BLIND METHOD; TIME FACTORS; TREATMENT OUTCOME;

EID: 36248968203     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.1080/10717540701606517     Document Type: Article

References (31)

1. Abdallah, A., and Saif, M. 1969. Clinical evaluation of niridazole in schistosoma haematobium and mansoni infections. Ann. NY Acad. Sci. 160:686-695.
2. Addy, M., and Renton-Harper, P. 1996. Local and systemic therapy in the management of periodontal disease: an opinion and review of the concept. J. Oral Rehab. 23:219-231.
3. Ahuja, A., Ali, A., and Rahman, S. 2006. Biodegradable periodontal intrapocket device containing metronidazole and amoxycillin: formulation and characterization. Pharmazie 61:25-29.
4. Andraus, P., Thomas, M., and Szubert, P. R. 1983. Praziquantel. Med. Res. Rev. 3:147-200.
5. Arrona, G., DeRosa, A., Rosso, F., et al. 1998. A biocompatibility study of the effects of slow-release antibiotic materials in the treatment of periodontal disease-I. The biocompatibility of cellulose acetate charged with 25% tetracycline hydrochloride. A clinical and scanning microscopic study of a case. Minerva Stomatol. 47:553-557.
6. Barat, R., Srinatha, A., Pandit, J. K., et al. 2006. Niridazole biodegradable inserts for local long-term treatment of periodontitis: possible new life for an orphan drug. Drug Del. 13: 365-373.
7. 2 synthesized by sol-gel processing. J. Mater. Sci. Mater. Med. 17:413-420.
8. Ciancio, S. G. 1999. Local delivery of chlorhexidine. Compend. Contin. Edu. Dent. 20:427-432.
9. Cimasoni, G. 1974. The crevicular fluid. In The monograph in Oral Science, 3rd vol. ed. Whitford, G.M. New York: Karger.
10. Coutinho, A., and Barreto, F. T. 1969. Treatment of hepatosplenic schistosomiasis mansoni with niridazole: relationships among liver function, effective dose, and side effects. Ann. NY Acad. Sci. 160:686-695.
11. Friedman, M., and Golomb, G. 1982. New sustained release dosage form of chlorhexidine for dental use. J. Periodontal Res. 17:323-328.
12. Friesen, L. R., Williams, K. B., Krause, L. S., and Killoy, W. J. 2002. Controlled local delivery of tetracycline with polymer strips in the treatment of periodontitis J. Periodontol. 73:13-19.
13. Goodson, J. M., Tanner, A., McArdle, S., et al. 1991. Multicenter evaluation of tetracycline fiber therapy. III Microbiological response. J. Periodontal Res. 26:440-451.
14. Hof, H., and Sticht-Groh. V. 1984. Antibacterial effects of niridazole: its effect on microaerophilic campylobacter. Infection 12:36-39.
15. Hof, H., and Stroder, J. 1986. Antibacterial activity of GO 10213, a nitroimidazole derivative. Antimicrob. Agents Chemother. 29:953-954.
16. Hof, H., Eisenbarth, B., Denzler, A., et al. 1985. Therapeutic activities of nitrothiazole derivatives in experimental infections with salmonella typhimurium and bacterioids fragilis. J. Antimicrob. Chemother. 6:205-210.
17. Kinnane, D. F., and Radvan, M. 1990. A six-month comparison of three periodontal local antimicrobial therapies in persistent periodontal pockets. J. Periodontol. 70:1-7.
18. Larsen, T., and Fiehn, N. E. 1997. Development of resistance to metronidazole and minocycline in vitro. J. Clin. Periodontol. 24:254-259.
19. Lu, H. K., and Chei, C. J. 2005. Efficacy of subgingivally applied minocycline in the treatment of chronic periodontitis. J. Perionotol. Res. 40:20-27.
20. Mahmoud, A. A. 1977. Current concepts: schistosomiasis. N. Engl. J. Med. 297:329-1331.
21. Mastiholimath, V. S., Dandagi, P. M., Gadad, A. P., et al. 2006. Formulation and evaluation of ornidazole dental implants for periodontitis. Ind. J. Pharm. Sci. 68:68-71.
22. Medlicott, N. J., Tucker, I. G., and Holborow, D. W. 1994. Delivery systems for the administration of drugs to the periodontal pocket. Adv. Drug Del. Rev. 13:181-203.
23. O'Connor, B. C., Newman, H. N., and Wilson, M. 1990. Susceptibility and resistance of plaque bacteria to minocycline. J. Periodontol. 61:228-233.
24. Ozturk, A. G., Ozturk, S. S., Palsson, B. O., et al. 1990. Mechanism of release from pellets coated with an ethylcellulose-based film. J. Control. Rel. 14:203-213.
25. Schwach-Abdellaoui, K., Vivien-Castioni, V., and Gurny, R. 2000. Local delivery of antimicrobial agents for the treatment of periodontal diseases. Eur. J. Pharm. Biopharm. 50:83-99.
26. Stabholz, A., Soskolene,W. A., Friedman, M., and Sela M. N. 1991. The use of sustained release chlorhexidine for the maintenance of periodontal pockets: 2-years clinical trial. J. Periodontol. 62:429-433.
27. Smith, S. R., Foyle, D. M., Needleman, I. G., and Pandya. N. V. 1998. The role of antibiotics in the treatment of periodontitis. Part I-systemic delivery. Eur. J. Prosthodont. Res. Dent. 3:79-86.
28. Somayaji, B.V., Jariwala, U., Jayachandran, P., et al. 1998. Evaluation of antimicrobial efficacy and release pattern of tetracycline and metronidazole using a local delivery. J. Periodontol. 69: 409-413.
29. Sun, Y., Wei-Fung, H., and Chih-Cheng, C. 1999. Spray coated and solution cast ethyl cellulose pseudolatex membranes. J. Membr. Sci. 157:159-170.
30. Wade, W. G., and Addy, M. 1987. Comparison of in vitro activity of niridazole, metronidazole and tetracycline against subgingival bacteria in chronic periodontitis. J. Applied Bacteriol. 63:455-457.
31. Wiljmans, J. G., and Baker, R.W. 1995. The solution-diffusion model: a review. J. Membr. Sci. 107:1-21.