Induction of intrinsic apoptosis pathway in colon cancer HCT-116 cells by novel 2-substituted-5,6,7,8-tetrahydronaphthalene derivatives

European Journal of Medicinal Chemistry

Volumn 77, Issue , 2014, Pages 323-333

  Gamal Eldeen, Amira M ^a   Hamdy, Nehal A ^a   Abdel Aziz, Hatem A ^a,b   El Hussieny, Enas A ^c   Fakhr, Issa M I ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c Ain Shams University   (Egypt)

Author keywords

1,2,3 Triazolo 1,5 a pyrimidine; 2 Acetyl tetralin; Apoptosis; Enaminone; Mitochondrial membrane potential; Pyranone; Pyrazolo 1,5 a pyrimidine; Pyrido 2,3 d pyrimidine

Indexed keywords

(5 HYDROXY 1 BENZOFURAN 3 YL)(5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)METHANONE; (5 HYDROXYNAPHTHO[1,2 B]FURAN 3 YL)(5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)METHANONE; 2 PHENYL 7 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PYRAZOLO[1,5 A]PYRIMIDINE; 2 SUBSTITUTED 5,6,7,8 TETRAHYDRONAPHTHALENE; 3 PHENYLAMINO 1 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PROP 2 EN 1 ONE; 3 [(4 CHLOROPHENYL)AMINO] 1 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PROP 2 EN 1 ONE; 3 [(4 METHOXYPHENYL)AMINO] 1 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PROP 2 EN 1 ONE; 3 [(4 NITROPHENYL)AMINO] 1 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PROP 2 EN 1 ONE; 3 [(4 TOLYL)AMINO] 1 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PROP 2 EN 1 ONE; 5 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL) 2 THIOXO 2,3 DIHYDROPYRIDO[2,3 D]PYRIMIDIN 4(1H) ONE; 5 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PYRIDO[2,3 D]PYRIMIDINE 2,4 (1H,3H) DIONE; 7 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)[1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; ACETAMIDE DERIVATIVE; ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; CASPASE 3; CASPASE 9; CYTOCHROME C; E 3 (N,N DIMETHYLAMINO) 1 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PROP 2 EN 1 ONE; E 3 (PIPERIDIN 1 YL) 1 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PROP 2 EN 1 ONE; E 3 MORPHOLINO 1 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PROP 2 EN 1 ONE; N [2 OXO 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL) 2H PYRAN 3 YL]ACETAMIDE; N [2 OXO 6 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL) 2H PYRAN 3 YL]BENZAMIDE; NAPHTHALENE DERIVATIVE; PACLITAXEL; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; 2-PHENYL-7-(5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)PYRAZOLO(1,5-A)PYRIMIDINE; 5-(5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)-2-THIOXO-2,3-DIHYDROPYRIDO(2,3-D)PYRIMIDIN-4(1H)-ONE; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL CULTURE; CELL DEATH; CELL LYSATE; CELL STRAIN HCT116; CELL VIABILITY; COLON CANCER; COLON CARCINOGENESIS; COLON CARCINOMA; CYTOTOXICITY; CYTOTOXICITY ASSAY; DNA DAMAGE; DNA FRAGMENTATION; HISTIOCYTIC LYMPHOMA; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; SIGNAL TRANSDUCTION; UTERINE CERVIX CARCINOMA; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; COLON TUMOR; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HCT116 CELL LINE; MCF 7 CELL LINE; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL CULTURE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL PROLIFERATION; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HUMANS; MCF-7 CELLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZOLES; PYRIDINES; PYRIMIDINES; PYRIMIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84896453488     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.03.021     Document Type: Article

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