1-[(benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles - Potent competitive inhibitors of aromatase

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 14, 1999, Pages 2105-2108

  Vinh, T K ^a   Ahmadi, M ^a   Lopez Delgado, P O ^a   Fernandez Perez, S ^a   Walters, H M ^a   Smith, H J ^a   Nicholls, P J ^a   Simons, C ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Benzofuran; Enzyme inhibition; P450 Aromatase; Triazole tetrazole

Indexed keywords

AMINOGLUTETHIMIDE; AROMATASE; AROMATASE INHIBITOR; IMIDAZOLE DERIVATIVE; LIAROZOLE;

ARTICLE; BREAST CANCER; CANCER THERAPY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION;

AMINOGLUTETHIMIDE; ANDROSTENEDIONE; AROMATASE; AROMATASE INHIBITORS; BENZOFURANS; ENZYME INHIBITORS; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; KETONES; PLACENTA; PREGNANCY; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES; TRIAZOLES;

EID: 0033584202     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00328-5     Document Type: Article

References (6)

1. Banting, L.; Nicholls, P.J.; Shaw, M.A.; Smith, H.J. Prog. Med. Chem. 1989, 26, 253-298.
2. De Coster, R.; Wouters, W.; Bowden, C.R.; Bossche, H.V.; Bruynseels, J.; Tuman, R.W., Vanginkel, R.; Snoeck, E.; Vanpeer, A.; Janssen, P.A.J. J. Steroid. Biochem. Molec. Biol. 1990, 37, 335-341.
3. Whomsley, R.; Fernandez, E; Nicholls, P.J.; Smith, H.J.; Lombardi, P.; Pestellini, V. J. Steroid. Biochem. Molec. Biol. 1993, 44, 675-676.
4. Pestellini, V.; Giannotti, D.; Giolitti, A.; Fanto, N.; Riviera, L.; Bellotti, M.G. Chemoterapia 1987, 6, 269-276.
5. Thompson, E.A.; Siiteri. P.K. J. Biol. Chem. 1974, 249, 5364-5372.
6. Shaw, M.A.; Nicholls, P.J.; Smith, H.J. J. Steroid Biochem. 1988, 31, 137-146.